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tetrahydropyran-2-yl-p-tolyl-amine | 25556-13-2

中文名称
——
中文别名
——
英文名称
tetrahydropyran-2-yl-p-tolyl-amine
英文别名
2-p-Tolylamino-tetrahydropyran;2-p-Toluidino-tetrahydropyran;N-(4-methylphenyl)oxan-2-amine
tetrahydropyran-2-yl-<i>p</i>-tolyl-amine化学式
CAS
25556-13-2
化学式
C12H17NO
mdl
——
分子量
191.273
InChiKey
SSJQURXCQCDVSI-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    320.1±35.0 °C(Predicted)
  • 密度:
    1.070±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    3.1
  • 重原子数:
    14
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.5
  • 拓扑面积:
    21.3
  • 氢给体数:
    1
  • 氢受体数:
    2

反应信息

  • 作为反应物:
    描述:
    tetrahydropyran-2-yl-p-tolyl-amine烯丙醇三乙基硼三丁基膦 、 palladium diacetate 作用下, 以 四氢呋喃正己烷 为溶剂, 反应 24.0h, 生成 5-(p-tolylamino)oct-7-en-1-ol
    参考文献:
    名称:
    Nucleophilic allylation of N,O-acetals with allylic alcohols promoted by Pd/Et3B and Pd/Et2Zn systems
    摘要:
    Pd/Et3B and Pd/Et2Zn systems promote the nucleophilic allylations of 2-aminotetrahydrofuran and 2-aminotetrahydropyran with allylic alcohols to provide omega-hydroxyhomoallylamines in high yields. The transformation is applicable to the allylation of non-protective carbohydrates, such as ribose and deoxyribose. (C) 2010 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tetlet.2010.12.064
  • 作为产物:
    描述:
    参考文献:
    名称:
    Nickel-catalyzed multi-component connection reaction of isoprene, aldimines (lactamines), and diphenylzinc
    摘要:
    Ni(acac)2 catalyzes the four-component connection reaction of diphenylzinc, isoprene, aromatic aldehydes, and aromatic amines in this order and provides stereochemically homogeneous (E)-1-arylamino-1-aryl-3-methyl-5-phenyl-3-pentenes (1) in excellent yields. Aliphatic aldehydes react similarly and give (E)-1-arylamino-1-alkyl-3-methyl-5-phenyl-3-pentenes (1) in slightly reduced yields. When the alkyl groups are bulky, in addition to I are formed (E)-1-arylamino-1-alkyl-4-methyl-5-phenyl-3-pentenes (F) as the minor products. Lactamines prepared in situ from five- and six-membered lactols and aromatic amines are more reactive than alkyl aldehyde aldimines and furnish (E)-4-arylamino-6-methyl-8-phenyl-6-octen-1-ols (4) and (E)-5-arylamino-7-methyl-9-phenyl-7-nonen-1-ols (5), respectively, in good yields with excellent E-stereoselectivity. (c) 2006 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2006.03.116
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文献信息

  • P4VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines
    作者:Farhad Shirini、Abdollah Fallah-Shojaei、Masoumeh Abedini、Laleh Samavi
    DOI:10.1007/s13738-016-0887-x
    日期:2016.9
    P4VPy–CuO nanoparticles were synthesized using ultrasound irradiations. Relevant properties of the synthesized nanoparticles were investigated by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. After identification, the prepared reagent was used for the promotion of different types of protection reactions of alcohols, phenols and amines. Easy workup, short reaction times, excellent yields, relatively low cost and reusability of the catalyst are the striking features of the reported methods.
    采用了超声波辐照法合成了P4VPy–CuO纳米粒子。通过X射线衍射、扫描电子显微镜、透射电子显微镜和傅里叶变换红外光谱对合成的纳米粒子的相关性质进行了研究。在鉴定之后,制备的试剂被用于促进不同类型的醇、酚和胺的保护反应。操作简便、反应时间短、产率高、成本相对较低以及催化剂的重复使用性是所报道方法的显著特点。
  • Nucleophilic allylation of N,O-acetals with allylic alcohols promoted by Pd/Et3B and Pd/Et2Zn systems
    作者:Yumi Yamaguchi、Mariko Hashimoto、Katsumi Tohyama、Masanari Kimura
    DOI:10.1016/j.tetlet.2010.12.064
    日期:2011.2
    Pd/Et3B and Pd/Et2Zn systems promote the nucleophilic allylations of 2-aminotetrahydrofuran and 2-aminotetrahydropyran with allylic alcohols to provide omega-hydroxyhomoallylamines in high yields. The transformation is applicable to the allylation of non-protective carbohydrates, such as ribose and deoxyribose. (C) 2010 Elsevier Ltd. All rights reserved.
  • Nickel-catalyzed multi-component connection reaction of isoprene, aldimines (lactamines), and diphenylzinc
    作者:Keisuke Kojima、Masanari Kimura、Satoshi Ueda、Yoshinao Tamaru
    DOI:10.1016/j.tet.2006.03.116
    日期:2006.8
    Ni(acac)2 catalyzes the four-component connection reaction of diphenylzinc, isoprene, aromatic aldehydes, and aromatic amines in this order and provides stereochemically homogeneous (E)-1-arylamino-1-aryl-3-methyl-5-phenyl-3-pentenes (1) in excellent yields. Aliphatic aldehydes react similarly and give (E)-1-arylamino-1-alkyl-3-methyl-5-phenyl-3-pentenes (1) in slightly reduced yields. When the alkyl groups are bulky, in addition to I are formed (E)-1-arylamino-1-alkyl-4-methyl-5-phenyl-3-pentenes (F) as the minor products. Lactamines prepared in situ from five- and six-membered lactols and aromatic amines are more reactive than alkyl aldehyde aldimines and furnish (E)-4-arylamino-6-methyl-8-phenyl-6-octen-1-ols (4) and (E)-5-arylamino-7-methyl-9-phenyl-7-nonen-1-ols (5), respectively, in good yields with excellent E-stereoselectivity. (c) 2006 Elsevier Ltd. All rights reserved.
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