申请人:Williams Michael S.
公开号:US20080281405A1
公开(公告)日:2008-11-13
Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastomeric and exhibits shape memory behavior, a hydrogel, or some combination thereof. Polymers used to fabricate the prostheses are selectively synthesized to exhibit desired characteristics such as crystallinity, strain fixity rate, strain recovery rate, elasticity, tensile strength, mechanical strength, cross-linking density, extent physical cross-linking, extent of covalent cross-linking, extent of interpenetrating networks, rate of erosion, heat of fusion, crystallization temperature, and acidity during erosion. The endolumenal prostheses convert to the deployed configuration following delivery to a treatment site, upon exposure to an initiator either present within the body naturally or introduced into the body.
本发明涉及一种容易且广泛地从传递配置转换到部署配置的内腔支架。内腔支架可以由一种或多种形状记忆聚合物、高模量弹性体、既具有弹性又表现出形状记忆行为的聚合物、水凝胶或其组合物制成。用于制造支架的聚合物被选择性地合成以表现出所需的特性,例如结晶度、应变固定率、应变恢复率、弹性、拉伸强度、机械强度、交联密度、物理交联程度、共价交联程度、互穿网络程度、侵蚀速率、熔融热、结晶温度以及侵蚀期间的酸度。内腔支架在输送到治疗部位后,通过暴露于体内自然存在或引入体内的引发剂,转换为部署配置。