N-[[bis(prop-2-enyl)amino]disulfanyl]-N-prop-2-enylprop-2-en-1-amine | 131387-62-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[[bis(prop-2-enyl)amino]disulfanyl]-N-prop-2-enylprop-2-en-1-amine
• CAS: 131387-62-7
• 化学式: C₁₂H₂₀N₂S₂
• 分子量: 256.436
• InChiKey: QOAPNAPUYZHROG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[[bis(prop-2-enyl)amino]disulfanyl]-N-prop-2-enylprop-2-en-1-amine 、 硫化碱 、 磺酰氯 、 sodium hydroxide 生成 N-[[bis(prop-2-enyl)amino]trisulfanyl]-N-prop-2-enylprop-2-en-1-amine
  参考文献：
  名称：

  KATRITZKY, ALAN R.;ZHAO, XIAOHONG;HITCHINGS, GREGORY J., SYNLETT,(1990) N, C. 473-476

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯化二硫 、 二烯丙基胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以70%的产率得到N-[[bis(prop-2-enyl)amino]disulfanyl]-N-prop-2-enylprop-2-en-1-amine
  参考文献：
  名称：

  Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides

  摘要：

  The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillinresistant S. aureus and F. tularensis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.056

文献信息

• [EN] ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES<br/>[FR] DISULFURES S-HÉTÉROSUBSTITUÉS ANTIBACTÉRIENS
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2009055677A1

  公开（公告）日：2009-04-30

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

  合成的S,S-杂二取代二硫化物在体外显示出对多种细菌具有强效的抗菌活性，包括金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和土拉里菌。本发明提供了有效治疗微生物/细菌感染的化合物、方法和组合物，特别是用于治疗已对传统抗生素产生抗药性的细菌引起的感染。
• Antibacterial S-heterosubstituted disulfides
  申请人：Turos Edward

  公开号：US10350177B2

  公开（公告）日：2019-07-16

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

  合成衍生的 S,S-互二取代二硫化物对多种细菌（包括金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和土拉弗氏菌）具有强效的体外抗菌活性。本发明提供了有效治疗微生物/细菌感染的化合物、方法和组合物，特别是治疗对传统抗生素产生抗药性的细菌引起的感染。
• ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES
  申请人：Turos Edward

  公开号：US20100204337A1

  公开（公告）日：2010-08-12

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus , methicillin-resistant Staphylococcus aureus and Francisella tularensis . The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.
• DIFFRACTION UNLIMITED PHOTOLITHOGRAPHY
  申请人：McLeod Robert R.

  公开号：US20120092632A1

  公开（公告）日：2012-04-19

  Methods, devices, systems, and materials are disclosed for diffraction unlimited photofabrication. A method is provided where a photoresponsive material is illuminated with a first optical pattern at a first wavelength of light. The first wavelength of light alters a solubility of the photoresponsive organic material. The photoresponsive material is also illuminated with a second optical pattern at a second wavelength of light. The second wavelength of light hinders the ability of the first wavelength of light to alter the solubility of the photoresponsive organic material where the second optical pattern overlaps the first optical pattern. The photoresponsive organic material is then developed.
• US8697346B2
  申请人：——

  公开号：US8697346B2

  公开（公告）日：2014-04-15