bis-diisobutylamino-disulfane | 859182-98-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-diisobutylamino-disulfane
• 英文别名: N.N'-Dithio-bis-diisobutylamin；Bis-diisobutylamino-disulfan；Bis-diisobutylamino-disulfid；N,Na(2)-Dithiobis[2-methyl-N-(2-methylpropyl)-1-propanamine]；N-[[bis(2-methylpropyl)amino]disulfanyl]-2-methyl-N-(2-methylpropyl)propan-1-amine
• CAS: 859182-98-2
• 化学式: C₁₆H₃₆N₂S₂
• 分子量: 320.607
• InChiKey: KRSWYJFCIRSVNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二异丁胺 在 二氯化二硫 、 乙醚 作用下， 生成 bis-diisobutylamino-disulfane
  参考文献：
  名称：

  Levi, Gazzetta Chimica Italiana, 1931, vol. 61, p. 295

  摘要：

  DOI：

文献信息

• [EN] ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES<br/>[FR] DISULFURES S-HÉTÉROSUBSTITUÉS ANTIBACTÉRIENS
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2009055677A1

  公开（公告）日：2009-04-30

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

  合成的S,S-杂二取代二硫化物在体外显示出对多种细菌具有强效的抗菌活性，包括金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和土拉里菌。本发明提供了有效治疗微生物/细菌感染的化合物、方法和组合物，特别是用于治疗已对传统抗生素产生抗药性的细菌引起的感染。
• Self-healing coatings for oil and gas applications
  申请人：Chilukuri Anusha

  公开号：US10316413B2

  公开（公告）日：2019-06-11

  A coated article comprises a substrate and a self-healing coating disposed on a surface of the substrate, the self-healing coating comprising a metallic matrix; and a plurality of micro- or nano-sized particles dispersed in the metallic matrix; the micro- or nano-sized particles comprising an active agent disposed in a carrier comprising a micro- or nano-sized metallic container, a layered structure, a porous structure, or a combination comprising at least one of the foregoing.

  一种涂层制品包括基底和设置在基底表面的自愈合涂层，自愈合涂层包括金属基质；以及分散在金属基质中的多个微米级或纳米级颗粒；微米级或纳米级颗粒包括设置在载体中的活性剂，载体包括微米级或纳米级金属容器、分层结构、多孔结构或包括上述至少一种结构的组合。
• Antibacterial S-heterosubstituted disulfides
  申请人：Turos Edward

  公开号：US10350177B2

  公开（公告）日：2019-07-16

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

  合成衍生的 S,S-互二取代二硫化物对多种细菌（包括金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和土拉弗氏菌）具有强效的体外抗菌活性。本发明提供了有效治疗微生物/细菌感染的化合物、方法和组合物，特别是治疗对传统抗生素产生抗药性的细菌引起的感染。
• Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
  作者：Praveen Ramaraju、Danielle Gergeres、Edward Turos、Sonja Dickey、Daniel V. Lim、John Thomas、Burt Anderson

  DOI：10.1016/j.bmcl.2012.04.056

  日期：2012.6

  The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillinresistant S. aureus and F. tularensis. (C) 2012 Elsevier Ltd. All rights reserved.
• SELF-HEALING COATINGS FOR OIL AND GAS APPLICATIONS
  申请人：Baker Hughes Incorporated

  公开号：EP3337917A1

  公开（公告）日：2018-06-27