(R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine | 1363808-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine
• 英文别名: (R)-(-)-1-(1-naphthyl)-N,N-bis(pyridin-4-ylmethyl)ethanamine；(1R)-1-naphthalen-1-yl-N,N-bis(pyridin-4-ylmethyl)ethanamine
• CAS: 1363808-69-8
• 化学式: C₂₄H₂₃N₃
• 分子量: 353.467
• InChiKey: SITRQNFCRMHBBV-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine 、 mercury dichloride 以 二氯甲烷 为溶剂， 以99%的产率得到Hg2Cl6((R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine)2
  参考文献：
  名称：

  Anion-Controlled Circular Dichroism Spectral Changes in Hg²⁺ Complexes with a Chiral Bidentate Ligand

  摘要：

  Anion-controlled circular dichroism (CD) spectral changes in Hg2+ complexes with a chiral bidentate ligand are reported. Although the Hg(CF3SO3)(2) and Hg(CF3CO2)(2) complexes with (R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine, (R)-(-)-1, show significant CD spectral changes, no CD spectral changes were observed in the HgCl2, HgBr2, Hg(CN)(2), or Hg(CH3CO2)(2) complexes. X-ray analysis indicates that both the (R)-(-)-1-Hg(CF3SO3)(2) and (R)-(-)-1-HgCl2 complexes form a coordination polymer and a discrete 2:3 [=(R)-(-)-1/H8Cl2] complex with a figure-eight structure. X-ray crystallography revealed that (i) the Hg Hg distances bridged by anions vary depending on the anions used and (ii) a coordination polymer cannot be formed when the Hg Hg distances are too short. Therefore, the formation of a coordination polymer is required to give the observed significant CD spectral changes.

  DOI：

  10.1021/ic301140z
• 作为产物：
  描述：

  4-吡啶甲醛 、 (R)-1-(1-萘基)乙胺 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 49.0h， 以75%的产率得到(R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine
  参考文献：
  名称：

  基于配合物结构的Hg 2+传感系统

  摘要：

  报告了基于复合物结构的新型Hg 2+传感系统的第一个例子。该系统结合了新的手性双齿配体和CD光谱。当添加Hg 2+时，观察到CD光谱发生明显变化，而在Li +，Na +，K +，Mg 2 +，Ca 2 +，Mn 2 +，Fe 2 +，Co的情况下，未观察到CD光谱的变化。2+，Ni 2 +，Cu 2 +，Zn 2 +，Rb +，Ag +，Cd 2 +，La 3+，Gd3+和Pb 2+。

  DOI：

  10.1021/ol3002943

文献信息

• Effects of structures of HgX2 complexes (X = CF3SO3 and Cl) with chiral bidentate ligands on circular dichroism spectra
  作者：Mari Ikeda、Shunsuke Kuwahara、Shim Sung Lee、Yoichi Habata

  DOI：10.1039/c2dt32712k

  日期：——

  The effects of the structures of HgX2 complexes (X = CF3SO3 and Cl) with chiral bidentate ligands [(R)-(−)-1-(1-naphthyl)-N,N-bis(pyridin-4-ylmethyl)ethanamine, (R)-(+)-1-phenyl-N,N-bis(pyridin-4-ylmethyl)ethanamine, (R)-(−)-1-(1-naphthyl)-N,N-bis(pyridin-3-ylmethyl)ethanamine, and (R)-(+)-1-phenyl-N,N-bis(pyridin-4-ylmethyl)ethanamine] on circular dichroism (CD) spectra are reported. The CD spectra

  HgX 2配合物（X = CF 3 SO 3和Cl）与手性双齿配体的结构[（R）-（-）-1-（1-萘基）-N，N-双（吡啶-4-基甲基）乙胺， （R）-（+）-1-苯基-N，N-双（吡啶-4-基甲基）乙胺， （R）-（-）-1-（1-萘基）-N，N-双（吡啶-3-基甲基）乙胺， 和 （R）-（+）-1-苯基-N，N-双（吡啶-4-基甲基）乙胺报道了圆二色性（CD）光谱。的免费的CD光谱（[R ）- （ - ） - 1A和（- [R ）- （+） - 1B，其具有4-吡啶基，类似于那些（[R ） - （ - ） -图2a和（- [R ）-（+）- 2b，具有3-吡啶基。当等摩尔量的Hg（CF 3 SO 3）2添加到这些配体时，观察到（R）-（-）- 2a的CD强度降低，并且在（R）-（-）- 2a中观察到显着的光谱变化（强度和形状）。R）-（-）- 1a，（R）-（+）-1b和（R）-（+）-
• Anion-Controlled Circular Dichroism Spectral Changes in Hg²⁺ Complexes with a Chiral Bidentate Ligand
  作者：Mari Ikeda、Shunsuke Kuwahara、Shim Sung Lee、Yoichi Habata

  DOI：10.1021/ic301140z

  日期：2012.7.2

  Anion-controlled circular dichroism (CD) spectral changes in Hg2+ complexes with a chiral bidentate ligand are reported. Although the Hg(CF3SO3)(2) and Hg(CF3CO2)(2) complexes with (R)-(-)-1-(naphthalen-1-yl)-N,N-bis(pyridin-4-ylmethyl)ethanamine, (R)-(-)-1, show significant CD spectral changes, no CD spectral changes were observed in the HgCl2, HgBr2, Hg(CN)(2), or Hg(CH3CO2)(2) complexes. X-ray analysis indicates that both the (R)-(-)-1-Hg(CF3SO3)(2) and (R)-(-)-1-HgCl2 complexes form a coordination polymer and a discrete 2:3 [=(R)-(-)-1/H8Cl2] complex with a figure-eight structure. X-ray crystallography revealed that (i) the Hg Hg distances bridged by anions vary depending on the anions used and (ii) a coordination polymer cannot be formed when the Hg Hg distances are too short. Therefore, the formation of a coordination polymer is required to give the observed significant CD spectral changes.
• Hg²⁺-Sensing System Based on Structures of Complexes
  作者：Mari Ikeda、Aya Matsu-ura、Shunsuke Kuwahara、Shim Sung Lee、Yoichi Habata

  DOI：10.1021/ol3002943

  日期：2012.3.16

  The first example of a new Hg2+-sensing system based on the structures of complexes is reported. The system uses a combination of a new chiral bidentate ligand and CD spectroscopy. Significant CD spectral changes are observed when Hg2+ is added, whereas no CD spectral changes are observed in the cases of Li+, Na+, K+, Mg2+, Ca2+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Rb+, Ag+, Cd2+, La3+, Gd3+, and Pb2+

  报告了基于复合物结构的新型Hg 2+传感系统的第一个例子。该系统结合了新的手性双齿配体和CD光谱。当添加Hg 2+时，观察到CD光谱发生明显变化，而在Li +，Na +，K +，Mg 2 +，Ca 2 +，Mn 2 +，Fe 2 +，Co的情况下，未观察到CD光谱的变化。2+，Ni 2 +，Cu 2 +，Zn 2 +，Rb +，Ag +，Cd 2 +，La 3+，Gd3+和Pb 2+。