3-thio-n-propyl-5,6-diphenyl-1,2,4-triazine | 352691-28-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-thio-n-propyl-5,6-diphenyl-1,2,4-triazine
• 英文别名: 5,6-Diphenyl-3-(propylsulfanyl)-1,2,4-triazine；5,6-diphenyl-3-propylsulfanyl-1,2,4-triazine
• CAS: 352691-28-2
• 化学式: C₁₈H₁₇N₃S
• 分子量: 307.419
• InChiKey: YLHLQWPDOCFTLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-碘代丙烷 、 5,6-二苯基-1,2,4-三嗪-3-硫醇 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 3-thio-n-propyl-5,6-diphenyl-1,2,4-triazine
  参考文献：
  名称：

  Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents

  摘要：

  The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-kappa B, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.097

文献信息

• Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents
  作者：Hamid Irannejad、Mohsen Amini、Fariba Khodagholi、Niloufar Ansari、Solaleh Khoramian Tusi、Mohammad Sharifzadeh、Abbas Shafiee

  DOI：10.1016/j.bmc.2010.04.097

  日期：2010.6.15

  The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-kappa B, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases. (C) 2010 Elsevier Ltd. All rights reserved.