N,N-bis(2-hydroxyethyl)-2-chloroaniline | 28005-78-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-bis(2-hydroxyethyl)-2-chloroaniline
• 英文别名: 2-chloro-N,N-bis(2-hydroxy-ethyl)-aniline；2-Chlor-N,N-bis-<2-hydroxy-aethyl>-anilin；N.N-Bis-(2-hydroxyaethyl)-2-chloranilin；2-[2-chloro-N-(2-hydroxyethyl)anilino]ethanol
• CAS: 28005-78-9
• 化学式: C₁₀H₁₄ClNO₂
• 分子量: 215.68
• InChiKey: FGNKJMWLDDNWRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-bis(2-hydroxyethyl)-2-chloroaniline 在 三乙胺 、 sodium chloride 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.33h， 生成 N,N-bis(2-chloroethyl)-2-chloroaniline
  参考文献：
  名称：

  Synthesis and structure–analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

  摘要：

  A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable (NRR3)-R-2 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via pi-pi interaction. Introduction of substituting group on the N-4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 mu M/kg, sc) and holds promise for development as a mechanically new analgesic drug. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.052
• 作为产物：
  描述：

  邻氯苯胺 、 2-氯乙醇 在 calcium carbonate 、 potassium iodide 作用下， 以 水 为溶剂， 反应 8.0h， 以52%的产率得到N,N-bis(2-hydroxyethyl)-2-chloroaniline
  参考文献：
  名称：

  Synthesis and structure–analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

  摘要：

  A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable (NRR3)-R-2 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via pi-pi interaction. Introduction of substituting group on the N-4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 mu M/kg, sc) and holds promise for development as a mechanically new analgesic drug. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.052

文献信息

• Black azo dyes
  申请人：——

  公开号：US20020049309A1

  公开（公告）日：2002-04-25

  Provided are novel black azo dyes which are useful in ink compositions, especially ink jet ink compositions. The dyes and ink compositions of the present invention exhibit a good balance of optical density, print reliability, water fastness and light fastness.

  本发明提供的新型黑色偶氮染料可用于油墨组合物，特别是喷墨油墨组合物。本发明的染料和油墨组合物在光密度、打印可靠性、耐水性和耐光性方面表现出良好的平衡。
• Effect of Nuclear Substitution on the Reaction of Aromatic Amines with Ethylene Oxide
  作者：MORRIS FREIFELDER、GEORGE R. STONE

  DOI：10.1021/jo01064a039

  日期：1961.5
• EP1320573A4
  申请人：——

  公开号：EP1320573A4

  公开（公告）日：2004-07-28
• BLACK AZO DYES
  申请人：Lexmark International, Inc.

  公开号：EP1320573A1

  公开（公告）日：2003-06-25
• INITIATING SYSTEM FOR SOLID POLYESTER GRANULE MANUFACTURE
  申请人：Orica Australia Pty Ltd

  公开号：EP1713835A1

  公开（公告）日：2006-10-25