butan-2-yl 2-(methylamino)benzoate | 1249958-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butan-2-yl 2-(methylamino)benzoate
• CAS: 1249958-23-3
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: ASOSVKWACJAYKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-甲基苯唑 、 仲丁醇 在 sodium hydroxide 作用下， 以50%的产率得到butan-2-yl 2-(methylamino)benzoate
  参考文献：
  名称：

  Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation

  摘要：

  A plant extract from the fruits of saw palmetto, which is currently used to treat the androgen‐dependent benign prostatic hyperplasia and PCa, served as source for new structure variants. We investigated the antiandrogenic potential of an ethanolic total extract and one of its main aromatic components anthranilic acid. An androgen receptor‐antagonistic (antiandrogenic) effect of the extract was evident, and although anthranilic acid itself revealed no remarkable effect, its methyl ester, methyl anthranilate, exhibited antiandrogenic potential. Based on this chemical structure, we synthesized and investigated the antiandrogenic activity of four AnA ester derivatives, which were either novel or only little described in literature. These AnA esters inhibit the androgen‐dependent transactivation of both the wild‐type (wt) androgen receptor and the androgen receptor point mutant T877A, which often occurs in refractory PCa. Moreover, they inhibit the androgen receptor‐induced expression of the endogenous prostate‐specific antigen. Importantly, AnA esters repress the growth of human PCa cells. Deletion analyses of androgen receptor propose that the antiandrogenic effect of anthranilic acid esters is mediated by the ligand‐binding domain, most likely through direct binding, without affecting androgen receptor protein levels. Taken together, the data suggest antiandrogenic potential of anthranilic acid ester derivatives, which can serve as lead structures for novel antiandrogens.

  DOI：

  10.1111/j.1747-0285.2011.01116.x

文献信息

• Compositions for use in golf balls
  申请人：Wu Shenshen

  公开号：US20050119451A1

  公开（公告）日：2005-06-02

  Golf balls comprising elastomer compositions are presently disclosed. These elastomer compositions comprise reaction products of polyisocyanates and telechelic polymers having isocyanate-reactive end-groups such as hydroxyl groups and/or amine groups. These elastomer compositions can be used in any one or more portions of the golf balls, such as inner core layer, intermediate core layer, outer core layer, intermediate layer, cover, inner cover layer, intermediate cover layer, and/or outer cover layer.

  目前公开了由弹性体组合物组成的高尔夫球。这些弹性体组合物包括多异氰酸酯和具有异氰酸酯反应性端基如羟基和/或胺基的远志聚合物的反应产物。这些弹性体组合物可用于高尔夫球的任何一个或多个部分，如内芯层、中间芯层、外芯层、中间层、盖层、内盖层、中间盖层和/或外盖层。
• COMPOSITIONS FOR USE IN GOLF BALLS
  申请人：Rajagopalan Murali

  公开号：US20060014923A1

  公开（公告）日：2006-01-19

  A golf ball having a core and at least one layer disposed about the core is disclosed. The at least one layer is formed from a composition having multiple reactive and/or non-reactive ingredients. At least one of these ingredients is a sterically hindered polyamine, preferably formed from an active hydrogen functional compound and an amine/acid ortho- or meta-substituted cyclic compound.

  本发明公开了一种高尔夫球，它具有一个球芯和围绕球芯设置的至少一层。至少一层由具有多种活性和/或非活性成分的组合物形成。这些成分中至少有一种是立体受阻多胺，最好由活性氢官能团化合物和胺/酸正代或偏代环状化合物形成。
• Compositions for golf equipment
  申请人：——

  公开号：US20040220375A1

  公开（公告）日：2004-11-04

  Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise reaction products of polyisocyanates and telechelic polymers having isocyanate-reactive end-groups such as hydroxyl groups and/or amine groups. These elastomer compositions can be used in any one or more portions of the golf balls, such as inner center, core, inner core layer, intermediate core layer, outer core layer, intermediate layer, cover, inner cover layer, intermediate cover layer, and/or outer cover layer.
• Compositions for Golf Equipment
  申请人：Wu Shenshen

  公开号：US20070093317A1

  公开（公告）日：2007-04-26

  Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise at least one poly(urethane-co-urea) prepolymer and at least one curative. These elastomer compositions can be used in any one or more portions of the golf balls, such as inner center, core, inner core layer, intermediate core layer, outer core layer, intermediate layer, cover, inner cover layer, intermediate cover layer, and/or outer cover layer.
• COMPOSITIONS FOR GOLF EQUIPMENT
  申请人：Rajagopalan Murali

  公开号：US20100255934A1

  公开（公告）日：2010-10-07

  The present invention is directed to golf balls having at least one layer formed from a polyurea composition. The polyurea is formed by combining an aliphatic polyurea prepolymer, a diamine curative, and a cyclic carbonate diluent. Golf balls of the present invention include one-piece, two-piece, multi-layer, and wound golf balls. The composition may be present in any one or more of a core layer, a cover layer, or an intermediate layer.