5H-Pyrido[2,3-D][1,2]oxazine | 253-79-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5H-Pyrido[2,3-D][1,2]oxazine
• 英文别名: 5H-pyrido[2,3-d]oxazine
• CAS: 253-79-2
• 化学式: C₇H₆N₂O
• 分子量: 134.14
• InChiKey: UPVQDRANAMJCTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Peroxycarboxylic ester initiators derived from nitrogen heterocycles
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0733649A1

  公开（公告）日：1996-09-25

  Peroxycarboxylic ester photoinitiators derived from aromatic nitrogen containing heterocyclic carboxylic acids are described. The heterocyclic aromatic ring may contain additional nitrogen atoms, be fused with another aromatic ring system, be substituted with an additional peroxycarboxylic ester group and/or be substituted with an electron group having a Hammett sigma value greater than 0.1. The peroxycarboxylic ester photoinitiators have been found to be useful in photopolymerizable compositions and photosensitive elements.

  所述过氧羧酸酯类光引发剂源自芳香族含氮杂环羧酸。杂环芳香环可包含额外的氮原子、与另一个芳香环系统融合、被一个额外的过氧羧酸酯基团取代和/或被一个哈米特西格玛值大于 0.1 的电子基团取代。已发现过氧羧酸酯类光引发剂在可光聚合的组合物和感光元件中非常有用。
• ELECTROCHEMICAL DEBLOCKING SOLUTION FOR ELECTROCHEMICAL OLIGOMER SYNTHESIS ON AN ELECTRODE ARRAY
  申请人：CustomArray,Inc.

  公开号：EP3521485A1

  公开（公告）日：2019-08-07

  There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

  本发明公开了一种用于电极微阵列的电化学解锁溶液。还进一步公开了一种使用该电化学解锁溶液在电极阵列上进行电化学合成的方法。该溶液和方法用于去除酸性保护基团，以便在电极微阵列上合成寡核苷酸、肽、小分子或聚合物，同时大幅提高与活性电极的解锁隔离度。该方法包括向电极阵列中的至少一个电极施加电压或电流。电极阵列被电化学解锁溶液覆盖。
• Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
  申请人：CustomArray, Inc.

  公开号：US10006131B1

  公开（公告）日：2018-06-26

  There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

  本发明公开了一种用于电极微阵列的电化学解锁溶液。还进一步公开了一种使用该电化学解锁溶液在电极阵列上进行电化学合成的方法。该溶液和方法用于去除酸性保护基团，以便在电极微阵列上合成寡核苷酸、肽、小分子或聚合物，同时大幅提高与活性电极的解锁隔离度。该方法包括向电极阵列中的至少一个电极施加电压或电流。电极阵列被电化学解锁溶液覆盖。
• Microarray having a base cleavable linker
  申请人：CustomArray, Inc.

  公开号：US10261075B2

  公开（公告）日：2019-04-16

  There is disclosed a microarray having base cleavable linkers and a process of making the microarray. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Optionally, oligomers are synthesized in situ onto the cleavable linkers and subsequently cleaved using a cleaving base. Optionally, the oligomers are cleaved and recovered as a pool of oligomers.

  本发明公开了一种具有碱基可裂解连接体的微阵列以及制造该微阵列的工艺。该微阵列的固体表面具有已知位置，每个位置都有活性羟基。已知位置的密度大于每平方厘米约 100 个位置。可以选择在可裂解连接体上就地合成低聚物，然后使用裂解碱进行裂解。可选地，低聚物被裂解后作为低聚物池回收。
• Electrode array device having an adsorbed porous reaction layer
  申请人：CUSTOMARRAY, INC.

  公开号：US10286377B1

  公开（公告）日：2019-05-14

  There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.

  本发明公开了一种具有吸附多孔反应层的电极阵列装置，可提高合成质量。该阵列包括基板上的多个电极，其中电极以电子方式连接到计算机控制系统。阵列在多个电极上具有吸附多孔反应层，其中吸附多孔反应层包括具有至少一个羟基的化学物质。在优选的实施方案中，反应层为蔗糖。本发明公开了一种用于制备提高合成质量的电极阵列的方法。该方法包括清洁方法和附着反应层的方法。清洗方法包括等离子清洗法和化学清洗法。通过将微阵列暴露于含有至少一个羟基的化学物质的溶液中，在清洗后附着反应层。