1-(4-methyl-2-phenylnaphthalen-1-yl)pentan-3-one | 1259017-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-methyl-2-phenylnaphthalen-1-yl)pentan-3-one
• 英文别名: 1-(4-Methyl-2-phenylnaphthalen-1-yl)pentan-3-one
• CAS: 1259017-12-3
• 化学式: C₂₂H₂₂O
• 分子量: 302.416
• InChiKey: GNBXPZRIXWLFAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(phenylethynyl)-2-(prop-1-en-2-yl)benzene 、 1-戊烯-3-酮 在 氧气 、 palladium dichloride 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以86%的产率得到1-(4-methyl-2-phenylnaphthalen-1-yl)pentan-3-one
  参考文献：
  名称：

  Palladium-Catalyzed Bisolefination of C−C Triple Bonds: A Facile Method for the Synthesis of Naphthalene Derivatives

  摘要：

  A highly efficient and mild palladium-mediated bisolefination of C-C triple bonds is described for the first time. With different types of olefin employed, this reaction terminates in diverse fashions. In addition to the merit of using oxygen as the sole oxidant, this reaction exhibits high reactivities and functionality tolerance simultaneously, thus providing a promising method for the synthesis of naphthalene derivatives.

  DOI：

  10.1021/ja108998d

文献信息

• Palladium-Catalyzed Bisolefination of C−C Triple Bonds: A Facile Method for the Synthesis of Naphthalene Derivatives
  作者：Chao Feng、Teck-Peng Loh

  DOI：10.1021/ja108998d

  日期：2010.12.22

  A highly efficient and mild palladium-mediated bisolefination of C-C triple bonds is described for the first time. With different types of olefin employed, this reaction terminates in diverse fashions. In addition to the merit of using oxygen as the sole oxidant, this reaction exhibits high reactivities and functionality tolerance simultaneously, thus providing a promising method for the synthesis of naphthalene derivatives.