(2E)-N-(4-Fluorophenyl)-2-(hydroxyimino)acetamide | 351-09-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E)-N-(4-Fluorophenyl)-2-(hydroxyimino)acetamide
• 英文别名: (2Z)-N-(4-fluorophenyl)-2-hydroxyiminoacetamide
• CAS: 351-09-7
• 化学式: C₈H₇FN₂O₂
• 分子量: 182.15
• InChiKey: DXSBFTGUEOWLSD-YHYXMXQVSA-N

物化性质

• 熔点：
  162
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2928000090

文献信息

• QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS
  申请人：Wilson Dean

  公开号：US20080167305A1

  公开（公告）日：2008-07-10

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及作为电压门控钠通道抑制剂有用的化合物。该发明还提供了包括本发明化合物的药学上可接受的组合物，以及使用这些组合物治疗各种疾病的方法。
• Process for preparing isatins with control of side-product formation
  申请人：Wilk Kazimierz Bogdan

  公开号：US20060247442A1

  公开（公告）日：2006-11-02

  Methods and kits for preventing or minimizing the formation of isatin oximes during formation of an isatin from an isonitrosoacetanilide are provided. Also provided are methods and kits for preventing or minimizing the formation of isatin oxime impurities after formation of an isatin from an isonitrosoacetanilide by using a decoy agent in the quenching and/or extraction steps. The isatins can be prepared using a decoy agent and desirably a strong acid. Further provided are methods for preparing isatin oximes.

  提供了一种防止或最小化在从异硝基乙酰苯胺制备异吲哚时形成异吲哚肟的方法和试剂盒。还提供了一种使用诱饵剂在淬灭和/或提取步骤中防止或最小化从异硝基乙酰苯胺制备异吲哚后形成异吲哚肟杂质的方法和试剂盒。可以使用诱饵剂和强酸制备异吲哚。还提供了制备异吲哚肟的方法。
• Quinazolines useful as modulators of ion channels
  申请人：Wilson Dean

  公开号：US20060173018A1

  公开（公告）日：2006-08-03

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及作为电压门控钠通道抑制剂有用的化合物。本发明还提供了包括本发明化合物的药学上可接受的组合物，以及使用这些组合物治疗各种疾病的方法。
• Quinazolines useful as modulators of voltage gated ion channels
  申请人：Wilson Dean

  公开号：US20080221137A1

  公开（公告）日：2008-09-11

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种作为电压门控钠通道抑制剂有用的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
• DIHYDROOROTATE DEHYDROGENASE INHIBITORS
  申请人：Thunuguntla Siva Sanjeeva Rao

  公开号：US20120028959A1

  公开（公告）日：2012-02-02

  The invention relates to compounds of formula (I) wherein R 1 , R 2 , X 1 , X 2 , Y, R a , R b , Q have the meanings given in claim 1 . The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

  本发明涉及式(I)的化合物，其中R1、R2、X1、X2、Y、Ra、Rb、Q的含义如权利要求书所述。该化合物在治疗自身免疫性疾病，如多发性硬化症，以及治疗癌症方面具有有用性。