2-(N,N-dimethylaminosulfonyl)benzene-sulfonamide | 88372-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(N,N-dimethylaminosulfonyl)benzene-sulfonamide
• 英文别名: 2-dimethylsulfamoylbenzenesulfonamide；N,N-dimethyl-1,2-benzenedisulfonamide；2-[(N,N-dimethylamino)sulfonyl]benzenesulfonamide；2-Sulfamoyl-benzolsulfonsaeure-dimethylamid；2-Sulfamoyl-benzolsulfonsaeuredimethylamid；2-Sulfamoylbenzol-sulfondimethylamid；2-N,2-N-dimethylbenzene-1,2-disulfonamide
• CAS: 88372-21-8
• 化学式: C₈H₁₂N₂O₄S₂
• mdl: MFCD11213201
• 分子量: 264.326
• InChiKey: XCSOAUKRYLZLLV-UHFFFAOYSA-N

物化性质

• 沸点：
  466.8±55.0 °C(Predicted)
• 密度：
  1.437±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(N,N-dimethylaminosulfonyl)benzene-sulfonamide 生成 1-N-[bis(methylsulfanyl)methylidene]-2-N,2-N-dimethylbenzene-1,2-disulfonamide
  参考文献：
  名称：

  TZENG, C. P.

  摘要：

  DOI：

文献信息

• N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide
  申请人：Kureha Kagaku Kogyo K.K.

  公开号：US06610853B1

  公开（公告）日：2003-08-26

  A herbicide containing as the active ingredient an N-(henylsulfonyl)picolinamide derivative represented by general formula (I) wherein X reprcsents a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, a C1-4 haloalkoxy, a (C1-4 alkoxy)carbonyl, a [di(C1-4 alkyl)amino]sulfonyl, an [N—(C1-4 alkyl)-N—(C1-4 alkoxy)amino]sulfonyl, a (C1-4 alkylamino)sulfonyl, a C1-4 alkylthio, a C1-4 alkylsulfinyl, a C1-4 alkylsulfonyl, or nitro; n is an integer of 0 to 5; Y represets a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, C1-4 haloalkoxy, a C1-4 alkylthio, a C1-4 haloalkylthio, amino, a C1-4 alkylamino, a di(C1-4 alkyl)amino, a (C1-4 alkoxy) C1-4 alkyl, a (C1-4 alkylthio) C1-4 alkyl, or nitro; and m is an integer of 0 to 4. This active ingredient is synthesized by condensing a substituted picolinic acid with a substituted benzenesulfonamide under dehydration, or by reacting the phenyl ester of a substituted picolinic acid with a substituted benzenesulfonamide in the presence of a basic compound.

  一种除草剂，其活性成分为一种由通式（I）表示的N-(苯基磺酰基)吡啶甲酰胺衍生物，其中X代表卤素、C1-4烷基、C1-4卤代烷基、C1-4烷氧基、C1-4卤代烷氧基、(C1-4烷氧基)羰基、[二(C1-4烷基)氨基]磺酰基、[N-(C1-4烷基)-N-(C1-4烷氧基)氨基]磺酰基、(C1-4烷基氨基)磺酰基、C1-4烷基硫醚、C1-4烷基亚砜基、C1-4烷基磺酰基或硝基；n为0至5的整数；Y代表卤素、C1-4烷基、C1-4卤代烷基、C1-4烷氧基、C1-4卤代烷氧基、C1-4烷基硫醚、C1-4卤代烷基硫醚、氨基、C1-4烷基氨基、二(C1-4烷基)氨基、(C1-4烷氧基)C1-4烷基、(C1-4烷基硫醚)C1-4烷基或硝基；m为0至4的整数。该活性成分通过将取代吡啶甲酸与取代苯磺酰胺在脱水条件下缩合合成，或者在碱性化合物存在下，将取代吡啶甲酸的苯酯与取代苯磺酰胺反应而制备。
• Herbicidal sulfonylureas
  申请人：BASF Aktiengesellschaft

  公开号：US05591694A1

  公开（公告）日：1997-01-07

  Substituted sulfonylureas of the formula I ##STR1## wherein, inter alia, n and m are each 0 or 1; X is O, S or N--R.sup.4, where R.sup.4 is hydrogen or alkyl; A is NO.sub.2, NH.sub.2, OH, CN, SCN, S(O).sub.o R.sup.5, SO.sub.2 NR.sup.6 R.sup.7 or ER.sup.7 ; and environmentally compatible salts of the compounds. The disclosure is also directed to a process for preparing the compounds, to intermediates for the preparation of the compounds and to the use of the compounds as herbicides.

  公式I的替代磺酰脲类化合物##STR1##其中，n和m分别为0或1；X为O、S或N--R.sup.4，其中R.sup.4为氢或烷基；A为NO.sub.2、NH.sub.2、OH、CN、SCN、S(O).sub.oR.sup.5、SO.sub.2NR.sup.6R.sup.7或ER.sup.7；以及这些化合物的环境兼容盐。该公开还涉及一种制备这些化合物的方法，用于制备这些化合物的中间体以及将这些化合物用作除草剂的用途。
• [EN] SULFONAMIDES AS TRPM8 MODULATORS<br/>[FR] SULFONAMIDES COMME MODULATEURS TRPM8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009012430A1

  公开（公告）日：2009-01-22

  ABSTRACT Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.

  摘要：本文披露了用于治疗各种疾病、综合症、症状和疾病的化合物、组合物和方法，包括疼痛。这些化合物由以下公式（I）表示：其中A、B、G、Y、R1、R2、R3和R4在此处定义。
• Herbicidal 2-(1H)-pyrazinones
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04802908A1

  公开（公告）日：1989-02-07

  This invention relates to a novel class of 2-(1H)-pyrazinones and their use as herbicides and plant growth regulants.

  本发明涉及一种新型的2-(1H)-吡嗪酮类化合物，其作为除草剂和植物生长调节剂的用途。
• Process for producing sulfonylureas
  申请人：Ciba-Geigy Corporation

  公开号：US04656273A1

  公开（公告）日：1987-04-07

  There is described a novel process for producing sulfonylureas of formula I ##STR1## wherein R.sub.1 is hydrogen or alkyl, R.sub.2 is ##STR2## E is .dbd.N-- or .dbd.CH--, R.sub.3 is alkyl, alkoxy or halogen, R.sub.4 is alkyl, cycloalkyl, alkoxy, halogen, alkoxy-alkyl, halo-alkyl or halo-alkoxy, R.sub.5 is hydrogen or alkyl, T is a substituted phenyl group ##STR3## Y is hydrogen or halogen, X is hydrogen, halogen, alkyl, halo-alkyl, alkenyl, halo-alkenyl, alkynyl, alkoxy, halo-alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halo-alkylthio, alkylsulfonyloxy, phenylsulfonyloxy, phenylsulfonyloxy mono- or polysubstituted by alkyl, or is di-alkylsulfamoyl, and A is a bridge member which has 3 or 4 atoms and which contains 1 or 2 hetero atoms, selected from the group consisting of oxygen, sulfur and nitrogen, the said process comprising reacting a silfonamide of the formula II T--SO.sub.2 --NH.sub.2 (II), in the presence of a base, with diphenyl carbonate to form a salt of a phenyl carbamate converting this salt into the free phenyl carbamate and reacting this further with an amine. Sulfonylureas are herbicidally effective compounds.

  本发明描述了一种生产式I的磺酰脲的新工艺。其中，R.sub.1为氢或烷基，R.sub.2为##STR2## E为.dbd.N--或.dbd.CH--，R.sub.3为烷基、烷氧基或卤素，R.sub.4为烷基、环烷基、烷氧基、卤素、烷氧基烷基、卤代烷基或卤代烷氧基，R.sub.5为氢或烷基，T为取代苯基##STR3## Y为氢或卤素，X为氢、卤素、烷基、卤代烷基、烯基、卤代烯基、炔基、烷氧基、卤代烷氧基、烷硫基、烷基亚砜基、烷基磺酰基、卤代烷硫基、烷基磺酰氧基、苯基磺酰氧基、被烷基单烷基取代或多取代的苯基磺酰氧基，或为二烷基磺酰胺基，A是一个桥接成员，具有3或4个原子，其中包含1或2个杂原子，选自氧、硫和氮的群，所述工艺包括在碱存在下，将式II T--SO.sub.2 --NH.sub.2 (II)的磺酰胺与二苯基碳酸酯反应，形成苯基氨甲酸盐，将该盐转化为游离的苯基氨甲酸酯，并进一步与胺反应。磺酰脲是除草有效化合物。