bis(trifluoromethyl)perfluorocyclohexylamine | 378-33-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: bis(trifluoromethyl)perfluorocyclohexylamine
• 英文别名: perfluorodimethyl-N-cyclohexylamine；bis-trifluoromethyl-undecafluorocyclohexyl-amine；Bis-trifluormethyl-undecafluorcyclohexyl-amin；(Perfluor-cyclohexyl)-bis-trifluormethyl-amin；Perfluoro(N,N-dimethylcyclohexylamin)；Perfluor-N,N-dimethyl-cyclohexylamin；Perfluorodimethylcyclohexylamine；1,2,2,3,3,4,4,5,5,6,6-undecafluoro-N,N-bis(trifluoromethyl)cyclohexan-1-amine
• CAS: 378-33-6
• 化学式: C₈F₁₇N
• 分子量: 433.068
• InChiKey: LIXDPHHZLNLBGW-UHFFFAOYSA-N

物化性质

• 沸点：
  110-111 °C
• 密度：
  1.835 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  bis(trifluoromethyl)perfluorocyclohexylamine 在 perfluorodimethyl-N-n-hexylamine 、 五氟化锑 作用下， 反应 3.0h， 以80%的产率得到perfluorocyclohexanone trifluoromethylimine
  参考文献：
  名称：

  Cleavage of perfluorinated tertiary amines by antimony pentafluoride

  摘要：

  DOI：

  10.1007/bf00953712
• 作为产物：
  描述：

  N,N-二甲基苯胺 在 氢氟酸 作用下， 生成 bis(trifluoromethyl)perfluorocyclohexylamine
  参考文献：
  名称：

  Fluorocarbon tertiary amines

  摘要：

  公开号：

  US02616927A1

文献信息

• Perfusate for preserving organ to be transplanted and preserving method
  申请人：The Green Cross Corporation

  公开号：EP0033402A1

  公开（公告）日：1981-08-12

  An organ to be transplanted, such as a kidney, can effectively be preserved for an increased period of time by perfusion using a perfusate which is made of a Ringer's solution modified by increasing its potassium ion content to 8-20 meq/liter with a stably emulsified perfluorocarbon compound and dissolved albumin. A preferred concentration of the perfluorocarbon compound, for example perfluorodecalin, is 7.5 to 12.5%(W/V) and that of albumin is 1-8%(W/V) based on the perfusate.

  灌注液是由林格氏溶液改良而成，改良后的林格氏溶液将钾离子含量提高到 8-20 meq/升，并加入了稳定乳化的全氟碳化合物和溶解的白蛋白。全氟碳化合物（例如全氟萘烷）的优选浓度为 7.5-12.5%(W/V)，白蛋白的优选浓度为灌流液的 1-8%(W/V)。
• Single-phase composition containing a perfluorinated oil and one or more surfactant(s), useful as an excipient for cosmetic and dermatologic formulations, as well as for biomedical applications
  申请人：ENIRICERCHE S.p.A.

  公开号：EP0296661A2

  公开（公告）日：1988-12-28

  A single-phase, either isotropic or anisotropic formulation is disclosed,which contains perfluorinated oil and one or more surfactant(s), is useful as an excipient for cosmetic and dermatologic formulations and is characterized in that at least one surfactant is selected from those having the following general formula: wherein: RF is an F-(CF₂-CF₂) i group; X is a group selected from: -(CH₂-O)K-; and -(CH₂-S)K-; wherein RI is a (C₁-C₄)-alkyl; Y is a group selected from: NH₂(RII)₂ and N(RII)₄; wherein RII is a hydrogen atom, or a group selected from -CH₂-CH₂-OH and (C₁-C₄)-alkyl; i is an integer comprised within the range of from 3 to 8; j is zero or 1; K is 2.l; l is an integer comprised within the range of from 1 to 10; m is 1 or 2. Such composition is spontaneously formed when the components are simply placed into contact with one another. In particular, in case of the isotropic form, the composition is a fluid, clear and stable composition, with particle size smaller than 400 Å , containing: (a) from 1 to 50% by weight of the perfluorinated oil; (b) from 1 to 50% by weight of water; (c) from 8 to 60% by weight of at least one surfactant selected from the above defined surfactants; (d) from 6 to 38% by weight of a co-surfactant, selected from (C₃-C₇)-aliphatic alcohols. In case of the anisotropic form, the composition has a high viscosity, and contains: (a) from 1 to 50% by weight of the perfluorinated oil; (b) from 1 to 80% by weight of water; (c) from 1 to 40% by weight of at least one surfactant selected from the above defined surfactants; (d) from 0 to 19% by weight of a co-surfactant, selected from (C₃-C₇)-aliphatic alcohols. Furthermore, in case of the isotropic composition this latter finds also use in the biomedical sector.

  本发明公开了一种各向同性或各向异性的单相制剂，它含有全氟油和一种或多种表面活性剂，可用作化妆品和皮肤科制剂的赋形剂，其特征在于至少一种表面活性剂选自具有以下通式的表面活性剂： 其中 RF 是 F-(CF₂-CF₂) i 基团； X 是选自以下的基团 -(CH₂-O)K-；和-(CH₂-S)K-； 其中 RI 是 (C₁-C₄)- 烷基； Y 是选自以下各项的基团 NH₂(RII)₂ 和 N(RII)₄； 其中 RII 是氢原子，或选自-CH₂-CH₂-OH 和 (C₁-C₄)- 烷基的基团； i 是 3 至 8 之间的整数； j 为 0 或 1； K 为 2.l； l 是 1-10 之间的整数； m 是 1 或 2。 当各组分简单地相互接触时，就会自发地形成这种组合物。 特别是在各向同性的情况下，这种组合物是一种流动、透明和稳定的组合物，其粒径小于 400 Å，含有以下成分： 1： (a) 1%至 50%（按重量计）的全氟油； (b) 1 至 50%（按重量计）的水； (c) 至少一种选自上述表面活性剂的表面活性剂，重量百分比为 8-60%； (d) 6-38%（重量）的助表面活性剂，选自(C₃-C₇)-脂肪醇。 在各向异性的情况下，组合物具有较高的粘度，并包含以下成分： (a) 1%至 50%（按重量计）的全氟油； (b) 1%至 80%（按重量计）的水 (c) 至少一种选自上述表面活性剂的表面活性剂（按重量计）（1-40%）； (d) 0-19%（重量）的助表面活性剂，选自(C₃-C₇)-脂肪醇。 此外，对于各向同性组合物，后者也可用于生物医学领域。
• Collagen products, processes for the preparation thereof and pharmaceutical compositions containing the same
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

  公开号：EP0322249A2

  公开（公告）日：1989-06-28

  The invention provides a storage stable lyophilized collagen product comprising acid soluble purified native collagen in combination with platelet growth factors and a pharmaceutical composition for enhancing wound healing comprising an aqueous solution of water soluble acid-soluble purified native collagen and platelet derived growth factors.

  本发明提供了一种贮存稳定的冻干胶原蛋白产品，包括酸溶性纯化原生胶原蛋白与血小板生长因子的组合，以及一种用于促进伤口愈合的药物组合物，包括水溶性酸溶性纯化原生胶原蛋白和血小板衍生生长因子的水溶液。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.8, 4, page 152 - 228
  作者：

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.9, 8, page 125 - 158
  作者：

  DOI：——

  日期：——