nitronitrophenolate | 46151-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: nitronitrophenolate
• 英文别名: dinitrophenolate；Phenol, dinitro-, ion(1-)-；2,3-dinitrophenolate
• CAS: 46151-11-5
• 化学式: C₆H₃N₂O₅
• 分子量: 183.1
• InChiKey: MHKBMNACOMRIAW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-Dinitrophenylacetat 在 水 作用下， 生成 nitronitrophenolate
  参考文献：
  名称：

  Tabushi, I.; Kuroda, Y.; Sakata, Y., Heterocycles, 1981, vol. 15, # 2, p. 815 - 818

  摘要：

  DOI：

文献信息

• METHODS (AMACR)
  申请人：UNIVERSITY OF BATH

  公开号：US20170176436A1

  公开（公告）日：2017-06-22

  A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

  描述了一种测量样本中α-甲基酰辅酶A羧化酶（AMACR）活性的方法，包括以下步骤：（i）提供样本；（ii）将所述样本与底物化合物接触，该化合物经过由所述AMACR催化的氢和一个离去基团的消除产生具有额外碳-碳双键的产物化合物；以及（iii）测量所述离去基团和/或所述产物化合物和/或未反应的底物化合物的量。还提供了诊断和医学成像的方法，特别用于诊断前列腺癌。还提供了用于上述方法的Formula 1的底物化合物。
• Method for Producing Polyhydroxyalkanoates
  申请人：Preishuber-Pflugl Peter

  公开号：US20090124787A1

  公开（公告）日：2009-05-14

  The invention relates to a process for preparing polyhydroxyalkanoates by polymerization of lactones of the general formula I, where the substituents and the index n have the meanings given in the description, in the presence of at least one catalyst of the formula (II) L I M a X a m , where the substituents and indices have the meanings given in the description. The invention further relates to poly-3-hydroxybutyrates which have a novel property profile and are obtainable for the first time by means of this process, and also biodegradable polyester mixtures based on these poly-3-hydroxybutyrates.

  本发明涉及一种通过在至少一种催化剂的存在下，聚合通式I的内酯制备聚羟基烷酸酯的方法，其中通式I的取代基和指数n的含义在说明中给出，催化剂的通式为(II) LIMaXam，其中取代基和指数的含义在说明中给出。本发明还涉及具有新的性质特征的聚-3-羟基丁酸酯，首次通过该方法获得，并且基于这些聚-3-羟基丁酸酯的可生物降解聚酯混合物。
• PROCESSES FOR THE PREPARATION OF DI-(2-AMINOETHYL) FORMAL, DI-(3-AMINOPROPYL) FORMAL, AND RELATED MOLECULES
  申请人：PASTINE Stefan J.

  公开号：US20130324764A1

  公开（公告）日：2013-12-05

  Disclosed herein are hardeners for use in making cleavable epoxy compositions, including compositions wherein components in contact with epoxy composition can be recovered, as well as methods of making such hardeners.

  本文披露了用于制造可分离环氧组合物的硬化剂，包括与环氧组合物接触的组分可以被回收的组合物，以及制造这种硬化剂的方法。
• Improved prodrugs of CC-1065 analogs
  申请人：Sanofi-Aventis

  公开号：EP1832577A1

  公开（公告）日：2007-09-12

  Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described; such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytoxic drugs in a targeted fashion.

  抗肿瘤抗生素CC-1065的类似物的前药具有可切割的保护基，其中保护基包含含有磺酸基的苯基氨基甲酸酯，保护基赋予前药增强的水溶性，并且前药还具有一种基团，例如硫化物或二硫化物，可以与细胞结合试剂（例如抗体）结合。还描述了这种前药偶联物的治疗用途；这种细胞毒素前药的前药具有治疗用途，因为它们可以以靶向的方式将细胞毒素前药传递到特定的细胞群体，以进行酶促转化为细胞毒素药物。
• PRODRUGS OF CC-A1065 ANALOGS
  申请人：Zhao Robert

  公开号：US20090028821A1

  公开（公告）日：2009-01-29

  The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates.

  本发明提供了抗肿瘤抗生素CC-1065的类似物前药物，其具有可切割的保护基，其中包含含苯基氨基甲酸磺酸，保护基使前药物具有增强的水溶性，并且前药物还具有一种基团，例如硫醚或二硫化物，可以与细胞结合试剂（如抗体）结合，以及使用这种前药物和结合物进行治疗的方法，以及制备这种前药物和结合物的过程。