bis(2,2,2-trifluoroethyl) chlorophosphite | 2196-03-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: bis(2,2,2-trifluoroethyl) chlorophosphite
• 英文别名: chloro-bis(2,2,2-trifluoroethoxy)phosphane
• CAS: 2196-03-4
• 化学式: C₄H₄ClF₆O₂P
• 分子量: 264.492
• InChiKey: KQCVLSRYFLBBDD-UHFFFAOYSA-N

物化性质

• 沸点：
  60 °C(Press: 15 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bis(2,2,2-trifluoroethyl) chlorophosphite 、 sodium isocyanate 以 乙腈 、 苯 为溶剂， 以47%的产率得到bis(2,2,2-trifluoroethyl) phosphorisocyanatidite
  参考文献：
  名称：

  Konovalova, I.V.; Burnaeva, L.A.; Loginova, I.V., Journal of general chemistry of the USSR, 1991, vol. 61, # 11.1, p. 2298 - 2302

  摘要：

  DOI：
• 作为产物：
  描述：

  bis(2,2,2-trifluoroethyl)phosphite 在 五氯化磷 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 bis(2,2,2-trifluoroethyl) chlorophosphite
  参考文献：
  名称：

  Phosphorus Containing Compound, and Electrolyte for Rechargeable Lithium Battery and Rechargeable Lithium Battery Including the Same

  摘要：

  公开号：

  EP2765135B1

文献信息

• Synthesis and separation of diastereomers of <i>O</i>-(2,2,2-trifluoroethyl)-3′,5′-dinucleoside phosphates
  作者：Weide Luo、Elena Atrazheva、Nancy Fregeau、William H. Gmeiner、J. William Lown

  DOI：10.1139/v94-193

  日期：1994.6.1

  The synthesis, diastereomeric separation, and characterization are described for a series of novel O-(2,2,2-trifluoroethyl)-3′,5′-dinucleoside phosphates, required for incorporation into antisense probes in the magnetic resonance imaging investigation of biodistribution. Preliminary assignment of the absolute configuration of the Rp and Sp diastereomers is made on the basis of 31 P NMR spectra.

  描述了一系列新型 O-(2,2,2-三氟乙基)-3',5'-双核苷磷酸酯的合成、非对映体分离和表征，在生物分布的磁共振成像研究中需要纳入反义探针. Rp 和 Sp 非对映异构体的绝对构型的初步分配是基于 31 P NMR 光谱进行的。
• Synthesis and Characterization of (Disilylanilino)Phosphines
  作者：Pradeep Devulapalli、Bin Wang、Robert H. Neilson

  DOI：10.1080/10426507.2015.1072196

  日期：2015.12.2

  The disilyl(4-bromo)aniline (Me3Si)(2)NC6H4Br (A) readily undergoes metal-halogen exchange to give the reactive organolithium derivative (Me3Si)(2)NC6H4Li (B). Subsequent reactions with various chlorophosphines, R(R)PCl, or chloro(disilylamino)phosphines, (Me3Si)(2)NP(R)Cl, were used to prepare three varieties of the title compounds: (Me3Si)(2)NC6H4P(R)R (1: R = R = NMe2; 2: R = R = OCH2CF3; 3: R = Ph, R = OCH2CF3; 4: R = R = Ph; 5: R = Ph, R = Me), (Me3Si)(2)NC6H4P(R)N(SiMe3)(2) [6: R = Me; 7: R = i-Pr; 8: R = n-Bu, 9: R = OCH2CF3; 10: R = C6H4N(SiMe3)(2); 11: R = Ph], and (Me3Si)(2)NC6H4P(Ph)R [12: R = n-Bu; 13: R = C6H4N(SiMe3)(2)]. The new compounds 1-13 were generally obtained as colorless, distillable liquids that were fully characterized by NMR (H-1, C-13, and P-31) spectroscopy and elemental analysis.
• Synthesis of Amido- and Diamidophosphites with Polyfluoroalkyl Substituents
  作者：S. F. Malysheva、N. K. Gusarova、N. A. Belogorlova、A. M. Nalibayeva、S. V. Yasko、N. A. Chernysheva、S. I. Verkhoturova、G. K. Bishimbayeva、B. A. Trofimov

  DOI：10.1134/s1070363220020103

  日期：2020.2

  Bis(polyfluoroalkyl) chlorophosphites and polyfluoroalkyl dichlorophosphites react easily with secondary amines (from -40 to -22 degrees C, 1-3 h, CH2Cl2) in the presence or absence of triethylamine to form the corresponding bis(polyfluoroalkyl) diorganylamidophosphites or bis(diorganylamido) polyfluoroalkyl phosphites in the yield of up to 74%. Bis(polyfluoroalkyl) diorganylamidophosphites were also synthesized from diorganylamidodichlorophosphites and polyfluoroalkanols (-25 to -22 degrees C, 2 h, Et3N-CH2Cl2) with a yield of 56-60%.