hepta-5,6-diene-1-amine | 107993-90-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hepta-5,6-diene-1-amine
• 英文别名: hepta-5,6-dien-1-amine；1-amino-5,6-heptadiene
• CAS: 107993-90-8
• 化学式: C₇H₁₃N
• 分子量: 111.187
• InChiKey: SXJWAIDBPMXZLT-UHFFFAOYSA-N

物化性质

• 沸点：
  173.7±10.0 °C(Predicted)
• 密度：
  0.785±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  hepta-5,6-diene-1-amine 在 Cp'2LnCH(TMS)2 作用下， 以95%的产率得到2-乙基-3,4,5,6-四氢吡啶
  参考文献：
  名称：

  Organolanthanide-Catalyzed Intramolecular Hydroamination/Cyclization of Aminoallenes

  摘要：

  DOI：

  10.1021/ja9743248
• 作为产物：
  描述：

  N-(5-己炔基)酞酰亚胺 在 一水合肼 、 二异丙胺 、 copper(I) bromide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 7.0h， 生成 hepta-5,6-diene-1-amine
  参考文献：
  名称：

  在技​​术条件下用于加氢胺化反应的市售且用户友好的催化剂

  摘要：

  介绍了一种简单的市售铜盐 [Cu(NCMe)4](BF4) 在炔烃和丙二烯的分子内加氢胺化反应中的活性。在空气存在下，在工业乙腈中成功进行了反应。虽然烯烃加氢胺化的尝试失败了，但也发现这种催化剂在分子间氮杂-迈克尔反应中具有活性。

  DOI：

  10.1002/ejoc.201900701

文献信息

• METHOD FOR PRODUCING 18F-LABELED COMPOUND AND HIGH MOLECULAR COMPOUND TO BE USED IN THE METHOD
  申请人：Takahashi Takashi

  公开号：US20120329968A1

  公开（公告）日：2012-12-27

  The present invention aims at solving the problems of conventional methods for producing an 18 F-labeled compound, that is, the problem of purification of a compound in a liquid phase synthesis method and the problem of an insufficient yield due to the reduction of reactivity in a solid phase synthesis method. There is provided a method for producing an 18 F-labeled compound including: allowing a high molecular compound containing a residue of a precursor compound to be labeled and a residue of a phase transfer catalyst in the molecule thereof to react with 18 F − ; and removing the 18 F-labeled compound from the high molecular compound.

  本发明的目的在于解决传统的18F-标记化合物生产方法的问题，即液相合成方法中化合物的纯化问题和固相合成方法中由于反应性降低导致产率不足的问题。提供了一种生产18F-标记化合物的方法，包括：使含有待标记前体化合物的残基和分子中的相转移催化剂残基的高分子化合物与18F-反应；并从高分子化合物中去除18F-标记化合物。
• Gold(I)-Catalyzed Intramolecular Dihydroamination of Allenes with <i>N</i>,<i>N</i>′-Disubstituted Ureas To Form Bicyclic Imidazolidin-2-ones
  作者：Hao Li、Ross A. Widenhoefer

  DOI：10.1021/ol900730w

  日期：2009.6.18

  mixture of gold(I) N-heterocyclic carbene complex (5)AuCl [5 = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidine] and AgPF6 at room temperature for 2 h led to isolation of bicyclic imidazolidin-2-one 4 in 93% yield with ≥98% diastereomeric purity. Gold-catalyzed dihydroamination was effective for a number of N-δ- and N-γ-allenyl ureas to form the corresponding bicyclic imidazolidin-2-ones in good yield

  的反应Ñ -δ-丙二烯尿素1与催化1：金1混合物（I）ñ -杂环卡宾配合物（5）AUCL [5 = 1,3-双（2,6-二异丙基苯基）咪唑-2-基啶] 和 AgPF 6在室温下放置 2 小时导致双环 imidazolidin-2-one 4 的分离，产率为 93%，非对映体纯度≥98%。金催化的二氢胺化可有效地使许多N - δ-和N - γ-烯基脲以良好的收率和高非对映选择性形成相应的双环 imidazolidin-2- one 。
• Combining Gold(I)/Gold(III) Catalysis and CH Functionalization: A Formal Intramolecular [3+2] Annulation towards Tricyclic Indolines and Mechanistic Studies
  作者：Guozhu Zhang、Yingdong Luo、Yanzhao Wang、Liming Zhang

  DOI：10.1002/anie.201100293

  日期：2011.5.2

  Gold rush: A combination of oxidative gold(I)/gold(III) catalysis and CH functionalization led to the first oxidative coupling between in situ generated alkyl gold reagents and CH bonds, affording tricyclic indolines through a formal [3+2] annulation between a vinyl group and an aniline moiety [see scheme; Tf=trifluoromethanesulfonyl, Selectfluor=1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo[2.2.2]octane

  淘金热：氧化金（I）/金（III）催化和CH官能化的组合导致原位生成的烷基金试剂和CH键之间的第一个氧化偶联，通过正式的[3+ 2]乙烯基和苯胺部分之间的环化[参见方案；参见图2。Tf ＝三氟甲磺酰基，Selectfluor ＝ 1-氯甲基-4-氟-1,4-二氮杂双环[2.2.2]辛烷双（四氟硼酸酯）]。
• METHODE FOR PRODUCING F-LABELLED COMPOUND AND HIGH MOLECULAR COMPOUND TO BE USED IN THE METHOD
  申请人：Tokyo Institute of Technology

  公开号：EP2537854A1

  公开（公告）日：2012-12-26

  The present invention aims at solving the problems of conventional methods for producing an 18F-labeled compound, that is, the problem of purification of a compound in a liquid phase synthesis method and the problem of an insufficient yield due to the reduction of reactivity in a solid phase synthesis method. There is provided a method for producing an 18F-labeled compound including: allowing a high molecular compound containing a residue of a precursor compound to be labeled and a residue of a phase transfer catalyst in the molecule thereof to react with 18F-; and removing the 18F-labeled compound from the high molecular compound.

  本发明旨在解决生产 18F 标记化合物的传统方法中存在的问题，即液相合成方法中的化合物纯化问题和固相合成方法中由于反应活性降低导致产率不足的问题。本发明提供了一种生产 18F 标记化合物的方法，包括：让含有待标记前体化合物残留物的高分子化合物及其分子中的相转移催化剂残留物与 18F- 反应；以及从高分子化合物中去除 18F 标记化合物。
• Solid-supported reagents composed of a copolymer possessing 2- O -sulfonyl mannosides and phase-transfer catalysts for the synthesis of 2-fluoroglucose
  作者：Ryota Takeuchi、Yuki Sakai、Hiroshi Tanaka、Takashi Takahashi

  DOI：10.1016/j.bmcl.2015.10.068

  日期：2015.12

  We described the synthesis of a solid-supported co-polymer possessing mannosides and phase-transfer catalysts and synthesis of 2-fluoroglucoside from it. We first prepared a soluble copolymer from two allene monomers possessing a precursor for the synthesis of 2-fluoroglycose and a crown ether. The copolymerization of the monomers via the pi-ally nickel-catalyst smoothly proceeded at room temperature to provide a desired copolymer without decomposition of the sulfonate esters. The copolymer exhibited high reactivity towards fluorination in comparison with a conventional precursor. We next synthesized the solid-supported copolymer by using the solid-supported initiator attached with TentaGel (R) resins. TentaGel (R) enabled polymerization under stirring with stirring bar without decomposition. The solid-supported copolymer exhibited comparable reactivity towards fluorination in comparison with the soluble copolymer. In addition, it can be easily separated from the reaction vessel by filtration. (C) 2015 Elsevier Ltd. All rights reserved.