3-phenoxy-propenal | 2862-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenoxy-propenal
• 英文别名: 3-Phenoxyprop-2-enal
• CAS: 2862-47-7
• 化学式: C₉H₈O₂
• 分子量: 148.161
• InChiKey: SIIYPVGAOHMXGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-phenoxy-propenal 以 乙酸乙酯 为溶剂， 生成 2-Methyl-5-phenoxy-pentadien-(2.4)-saeure-(1)
  参考文献：
  名称：

  Zur Darstellung von Phenoxyradikalen

  摘要：

  DOI：

  10.1007/bf00908995
• 作为产物：
  描述：

  3-苯氧基丙-2-烯-1-醇 在 dipyridine chromium trioxide 作用下， 生成 3-phenoxy-propenal
  参考文献：
  名称：

  Gelin,R.; Makula,D., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1964, vol. 258, p. 5234 - 5236

  摘要：

  DOI：

文献信息

• Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
  申请人：Lan-Hargest Hsuan-Yin

  公开号：US20050282890A1

  公开（公告）日：2005-12-22

  Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or to stimulate hematopoietic cells ex vivo.

  组蛋白去乙酰化酶是一种含锌活性位点的金属酶。具有结合锌的基团的化合物，例如α-酮酰环氧基团，如α-酮硫基团，可以抑制组蛋白去乙酰化酶。组蛋白去乙酰化酶抑制可以抑制基因表达，包括与肿瘤抑制相关的基因表达。因此，抑制组蛋白去乙酰化酶可以提供一种替代途径用于治疗癌症、血液学疾病，例如血红蛋白病、常染色体显性疾病，例如脊髓肌萎缩症和亨廷顿病，遗传相关代谢性疾病，例如囊性纤维化和肾上腺白质病，或刺激外体造血细胞。
• Histone deacetylase inhibitors based on alpha-chalcogenmethylcarbonyl compounds
  申请人：Beacon Laboratories, Inc.

  公开号：US20040023944A1

  公开（公告）日：2004-02-05

  Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-chalcogenmethylcarbonyl group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or for stimulating hematopoietic cells ex vivo.

  组蛋白去乙酰化酶是一种含有活性位点锌的金属酶。具有锌结合基团的化合物，例如α-硫代酮基团，如α-硫代酮基团，可以抑制组蛋白去乙酰化酶。组蛋白去乙酰化酶抑制可以抑制基因表达，包括与肿瘤抑制相关的基因表达。因此，抑制组蛋白去乙酰化酶可以提供一种替代途径来治疗癌症、血液疾病（例如血红蛋白病）、常染色体显性疾病（例如脊髓肌萎缩症和亨廷顿病）、遗传相关代谢性疾病（例如囊性纤维化和肾上腺白质病），或用于刺激外体造血细胞。
• Histone deacetylase inhibitors based on trihalomethylcarbonyl compounds
  申请人：Beacon Laboratories, Inc.

  公开号：US20040029903A1

  公开（公告）日：2004-02-12

  Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, a trihalomethylcarbonyl group, such as a trifluoromethylcarbonyl group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or for stimulating hematopoietic cells ex vivo.

  组蛋白去乙酰化酶是一种含有锌活性位点的金属酶。含有锌结合基团的化合物，例如三卤甲基羰基基团，如三氟甲基羰基基团，可以抑制组蛋白去乙酰化酶。组蛋白去乙酰化酶抑制可以抑制基因表达，包括与肿瘤抑制相关的基因表达。因此，抑制组蛋白去乙酰化酶可以提供一种替代途径来治疗癌症、血液疾病，如血红蛋白病、常染色体显性疾病，如脊髓肌萎缩和亨廷顿病，遗传相关代谢性疾病，如囊性纤维化和肾上腺白质异构酸病，或刺激体外造血细胞。
• Histone deacetylase inhibitors
  申请人：Lan-Hargest Hsuan-Yin

  公开号：US20070037869A1

  公开（公告）日：2007-02-15

  Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, genetic disorders, e.g. Huntington's disease and spinal muscular atrophy and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

  组蛋白去乙酰化酶是一种含有锌活性位点的金属酶。具有锌结合基团的化合物，例如羟基酰胺基团或羧酸基团，可以抑制组蛋白去乙酰化酶。组蛋白去乙酰化酶的抑制可以抑制基因表达，包括与肿瘤抑制相关的基因表达。因此，抑制组蛋白去乙酰化酶可以提供一种替代途径来治疗癌症、血液疾病（例如血红蛋白病）、遗传疾病（例如亨廷顿病和脊髓性肌萎缩症）和与遗传相关的代谢性疾病（例如囊性纤维化和肾上腺白质脑病）。
• HISTONE DEACETYLASE INHIBITORS
  申请人：Lan-Hargest Hsuan-Yin

  公开号：US20110288168A1

  公开（公告）日：2011-11-24

  Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, genetic disorders, e.g. Huntington's disease and spinal muscular atrophy and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

  组蛋白去乙酰化酶是一种含有锌活性位点的金属酶。具有锌结合基团的化合物，例如羟肟酸基团或羧酸基团，可以抑制组蛋白去乙酰化酶。组蛋白去乙酰化酶抑制可以抑制基因表达，包括与肿瘤抑制相关的基因表达。因此，抑制组蛋白去乙酰化酶可以提供一种替代途径来治疗癌症、血液学疾病（例如血红蛋白病）、遗传疾病（例如亨廷顿病和脊髓肌萎缩症）和遗传相关代谢性疾病（例如囊性纤维病和肾上腺白质脑病）。