2-amino-5-methyl-4-(naphthalen-1-yl)isophthalonitrile | 1338442-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-amino-5-methyl-4-(naphthalen-1-yl)isophthalonitrile
• 英文别名: 2-Amino-5-methyl-4-naphthalen-1-ylbenzene-1,3-dicarbonitrile；2-amino-5-methyl-4-naphthalen-1-ylbenzene-1,3-dicarbonitrile
• CAS: 1338442-80-0
• 化学式: C₁₉H₁₃N₃
• 分子量: 283.332
• InChiKey: MRQGRKJJYREEPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-5-methyl-4-(naphthalen-1-yl)isophthalonitrile 、 溴乙酸乙酯 在 potassium hydroxide 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以15.7%的产率得到ethyl 3-amino-7-cyano-1-(2-ethoxy-2-oxoethyl)-5-methyl-6-(naphthalen-1-yl)-1H-indole-2-carboxylate
  参考文献：
  名称：

  One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles

  摘要：

  A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.064
• 作为产物：
  描述：

  1-萘甲醛 、 丙醛 、 丙二腈 在 吗啉 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以77%的产率得到2-amino-5-methyl-4-(naphthalen-1-yl)isophthalonitrile
  参考文献：
  名称：

  One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles

  摘要：

  A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.064

文献信息

• One-step method for the synthesis of aryl olefins from aryl aldehydes and aliphatic aldehydes
  作者：Hanumant B. Borate、Supriya H. Gaikwad、Ananada S. Kudale、Subhash P. Chavan、Shrikant G. Pharande、Vitthal D. Wagh、Vikram S. Sawant

  DOI：10.1016/j.tetlet.2013.01.008

  日期：2013.3

  A conceptually new one-step reaction affording unexpected aryl olefinic product from aromatic aldehyde, aliphatic aldehyde and malononitrile in the presence of acetic acid-ammonium acetate under mild reaction conditions without using any metal catalyst is reported. This novel reaction was used to prepare a number of substituted aryl olefins including new molecules.

  据报道，在乙酸-乙酸铵存在下，在温和的反应条件下，无需使用任何金属催化剂，即可从芳香族醛，脂肪族醛和丙二腈得到意想不到的芳基烯烃产物，这是一种概念上新颖的一步反应。该新颖的反应用于制备包括新分子在内的许多取代的芳基烯烃。
• One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles
  作者：Sangmeshwer P. Sawargave、Ananada S. Kudale、Jaydeep V. Deore、Dattatry S. Bhosale、Jaisingh M. Divse、Subhash P. Chavan、Hanumant B. Borate

  DOI：10.1016/j.tetlet.2011.08.064

  日期：2011.10

  A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.