dichlorophenolindophenol | 537-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dichlorophenolindophenol
• 英文别名: 2,6-dichlorphenolindophenol；2,6-dichlorophenolindophenol；2,6-dichloroindophenol；DCIP；2,6-Dichlorindophenol；dichloroindophenol；DCPIP；4-(3,5-dichloro-4-hydroxyphenyl)iminocyclohexa-2,5-dien-1-one
• CAS: 537-14-4
• 化学式: C₁₂H₇Cl₂NO₂
• 分子量: 268.099
• InChiKey: FBWADIKARMIWNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dichlorophenolindophenol 在 盐酸 、 溴代十六烷基吡啶 作用下， 以 乙醇 为溶剂， 生成 Phenolindo-2,6-dichlorophenol anion
  参考文献：
  名称：

  Shinkai, Seiji; Matsuo, Katsuta; Harada, Akiko, Journal of the Chemical Society. Perkin transactions II, 1982, p. 1261 - 1266

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氯醌-4-氯亚胺 生成 dichlorophenolindophenol
  参考文献：
  名称：

  JOSEPHY, P. D.;VAN, DAMME, A., ANAL. CHEM., 1984, 56, N 4, 813-814

  摘要：

  DOI：
• 作为试剂：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 dichlorophenolindophenol 作用下， 生成 2'-Methoxy-2,4,6-trimethyl-benzil
  参考文献：
  名称：

  The Preparation and Properties of an Ene-diol. α-o-Methoxyphenyl-β-mesitoyl-acetylene Glycol

  摘要：

  DOI：

  10.1021/ja01262a008

文献信息

• Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
  申请人：Leban Johan

  公开号：US20060199856A1

  公开（公告）日：2006-09-07

  The present invention relates to a novel compounds that can be used as anti-inflammatory, immunomodulatory and antiproliferatory agents. In particular, the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehyrogenase (DHODH).

  本发明涉及一种新型化合物，可用作抗炎、免疫调节和抗增殖剂。具体而言，本发明涉及抑制二氢乳酸脱氢酶（DHODH）的新化合物，以及制造它们的方法、含有它们的制药组合物和它们在治疗和预防疾病方面的用途，特别是在抑制二氢乳酸脱氢酶（DHODH）具有优势的疾病中的使用。
• Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
  申请人：4SC AG

  公开号：US07423057B2

  公开（公告）日：2008-09-09

  The present invention relates to a novel compounds that can be used as anti-inflammatory, immunomodulatory and antiproliferatory agents. In particular, the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehyrogenase (DHODH).

  本发明涉及一种新型化合物，可用作抗炎、免疫调节和抗增殖剂。具体而言，本发明涉及新型化合物，其抑制双氢乳酸酸脱氢酶（DHODH）的过程，以及制造这些化合物的方法，包含它们的制药组合物，以及它们用于治疗和预防疾病的用途，特别是在需要抑制双氢乳酸酸脱氢酶（DHODH）的疾病中的应用。
• D-Glucaric Acid Producing Bacterium, and Method for Manufacturing D-Glucaric Acid
  申请人：Ensuiko Sugar Refining Co., Ltd.

  公开号：US20150152448A1

  公开（公告）日：2015-06-04

  The present invention provides a D-glucaric acid-producing bacterium and a method for producing D-glucaric acid. The present invention is characterized in that D-glucaric acid or a salt thereof is produced from one or more saccharides selected from the group consisting of D-glucose, D-gluconic acid and D-glucuronic acid with catalytic action of a specific alcohol dehydrogenase PQQ-ADH (1) and a specific aldehyde dehydrogenase PQQ-ALDH (2), and that D-glucaric acid or a salt thereof is produced by using a microorganism having the PQQ-ADH (1) and the PQQ-ALDH (2) or a processed product thereof in the presence of the one or more saccharides. The present invention can provide a microorganism having improved productivity of D-glucaric acid to be used for production of D-glucaric acid and a method for efficiently producing D-glucaric acid.

  本发明提供了一种D-葡萄糖醛酸盐酸生产细菌和一种生产D-葡萄糖醛酸盐酸的方法。本发明的特点在于，利用特定的醇脱氢酶PQQ-ADH（1）和特定的醛脱氢酶PQQ-ALDH（2）的催化作用，从D-葡萄糖、D-葡萄糖酸和D-葡萄糖醛酸等一种或多种被选自的糖中产生D-葡萄糖醛酸盐酸或其盐，并且在存在一种或多种糖的情况下，使用具有PQQ-ADH（1）和PQQ-ALDH（2）或其加工产品的微生物来产生D-葡萄糖醛酸盐酸或其盐。本发明可以提供一种具有改善D-葡萄糖醛酸盐酸生产能力的微生物，用于生产D-葡萄糖醛酸盐酸，并且可以高效地生产D-葡萄糖醛酸盐酸。
• CARBON MEMBRANE HAVING BIOLOGICAL MOLECULE IMMOBILIZED THEREON
  申请人：Yoshida Youichi

  公开号：US20090192297A1

  公开（公告）日：2009-07-30

  Disclosed is a biological molecule-immobilized carbon membrane which comprises a porous carbon membrane and a biological molecule (e.g., an enzyme) immobilized on the carbon membrane, wherein the porous carbon membrane has three-dimensional cancellous pores through which fluid can permeate. The carbon membrane can have a large amount of a biological molecule (e.g., an enzyme) immobilized thereon and can also have a higher level of enzymatic activity or the like compared to a conventional one. Therefore, the carbon membrane is useful as an electrode for a bio-sensor or a bio-fuel cell.

  本发明揭示了一种生物分子固定化碳膜，包括多孔碳膜和生物分子（例如酶）固定在碳膜上，其中多孔碳膜具有三维多孔结构，使流体可以渗透。该碳膜上可以固定大量的生物分子（例如酶），并且相对于传统的碳膜，具有更高的酶活性等水平。因此，该碳膜可用作生物传感器或生物燃料电池的电极。
• Mechanism of the Gibbs Reaction. 3. Indophenol Formation via Radical Electrophilic Aromatic Substitution (SREAr) on Phenols
  作者：Istvan Pallagi、Andras Toro、Odon Farkas

  DOI：10.1021/jo00101a013

  日期：1994.11

  Different products are formed, depending on the para substituent (R) when 2,6-dichlorobenzoquinone N-chloroimine (1b) reacts with the anion of the 4-substituted phenol (2). If the group R can leave as a cation (i.e., R is an electrofugal leaving group) such as H, CH(2)NMe(2), CH2OH, etc., then the reaction yields indophenol (3), the normal Gibbs product. If the group R cannot leave as a cation such as CH3, the final product of the reaction will be type 10, 1,1-disubstituted 2,5-cyclohexadienone. If the group R is OH or NH2, then the reaction gives the corresponding benzoquinone 4 or benzoquinone imine 1 and 2,6-dichlorobenzoquinone imine (1d). In all these cases the reaction proceeds at a 1:1 stoichiometry. If, however, the group R can leave as an anion (i.e., R is nucleofugal leaving group) such as halogen, alkoxy, or OCH(2)Ph, then the reaction proceeds at a 1:2 stoichiometry. In this case the reaction of a second mole of phenolate with type 26 intermediate yields the indophenol product 3 and the oxidized product of the phenol. If the two ortho positions of the phenolate are substituted then the oxidized product of the phenol will be the corresponding benzoquinone. The mechanism of the reaction has been studied by kinetic and nonkinetic (NMR) methods. It has been concluded that the first step of the mechanism is a single electron transfer (SET) from the phenolate to the benzoquinone N-chloroimine 1b which is the rate-determining process in most of the cases. In some of the nucleofugal cases the final oxidation, involving the second mole of phenolate, is the rate-determining step. For the radical reaction three different alternatives are suggested: a combination of radicals in a solvent cage (direct reaction) and two different chain reactions (chain A and chain B). Quantum chemical calculations revealed that the direct reaction and the chain A mechanisms were energetically more favored than chain B. The reaction shows an extremely large para selectivity although the substitution does follow a radical mechanism.