N-(2'-hydroxybenzyl)hydroxylamine | 646066-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-(2'-hydroxybenzyl)hydroxylamine
• 英文别名: o-hydroxybenzylhydroxylamine；N-salicylhydroxylamine；2-[(Hydroxyamino)methyl]phenol
• CAS: 646066-95-7
• 化学式: C₇H₉NO₂
• 分子量: 139.154
• InChiKey: SZZPZKILRJMMOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2'-hydroxybenzyl)hydroxylamine 在 叔丁基对羟基茴香醚 作用下， 以 甲苯 、 苯 为溶剂， 反应 54.0h， 生成
  参考文献：
  名称：

  A Ratiometric Fluorescent Sensor for Ag^I with High Selectivity and Sensitivity

  摘要：

  A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene.

  DOI：

  10.1021/ja029253d
• 作为产物：
  描述：

  (E)-2-羟基苯甲醛肟 在 盐酸 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 以52%的产率得到N-(2'-hydroxybenzyl)hydroxylamine
  参考文献：
  名称：

  A Ratiometric Fluorescent Sensor for Ag^I with High Selectivity and Sensitivity

  摘要：

  A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene.

  DOI：

  10.1021/ja029253d

文献信息

• A Catalytic Tethering Strategy: Simple Aldehydes Catalyze Intermolecular Alkene Hydroaminations
  作者：Melissa J. MacDonald、Derek J. Schipper、Peter J. Ng、Joseph Moran、André M. Beauchemin

  DOI：10.1021/ja208867g

  日期：2011.12.21

  Herein we describe a catalytic tethering strategy in which simple aldehyde precatalysts enable, through temporary intramolecularity, room-temperature intermolecular hydroamination reactivity and the synthesis of vicinal diamines. The catalyst allows the formation of a mixed aminal from an allylic amine and a hydroxylamine, resulting in a facile intramolecular hydroamination event. The promising enantioselectivities

  在本文中，我们描述了一种催化束缚策略，其中简单的醛预催化剂通过临时分子内、室温分子间加氢胺化反应和邻二胺的合成来实现。该催化剂允许由烯丙胺和羟胺形成混合胺醛，从而导致容易的分子内加氢胺化事件。用手性醛获得的有希望的对映选择性也突出了这种催化束缚方法在不对称催化中的潜力，并证明仅依赖临时分子内的有效对映诱导是可能的。
• Synthesis and tyrosinase inhibitory activity of novel N-hydroxybenzyl-N-nitrosohydroxylamines
  作者：Mitsuhiro Shiino、Yumi Watanabe、Kazuo Umezawa

  DOI：10.1016/s0045-2068(03)00026-9

  日期：2003.4

  Several novel N-substituted N-nitrosohydroxylamines were synthesized. They all inhibited mushroom tyrosinase, but the type of inhibition was different depending on the substituent. Some N-(mono- or dihydroxybenzyl)-N-nitrosohydroxylamines exhibited uncompetitive inhibition with respect to (L)-dopa. Among them, compound 6 was also a competitive inhibitor with respect to oxygen. This observation suggests that another interaction by the meta- or para-hydroxyl group might stabilize the binding of the inhibitor to the enzyme through the oxygen binding site. (C) 2003 Elsevier Science (USA). All rights reserved.
• PROCESS FOR THE PRODUCTION OF A POLYBENZOXAZINE MONOMER
  申请人：ARIANEGROUP SAS

  公开号：US20220177437A1

  公开（公告）日：2022-06-09

  A process for manufacturing a polybenzoxazine monomer, crosslinking the latter, and using the crosslinked product to form an ablative thermal protection system for a thruster nozzle or atmospheric reentry body.
• US4312887A
  申请人：——

  公开号：US4312887A

  公开（公告）日：1982-01-26
• A Ratiometric Fluorescent Sensor for Ag^I with High Selectivity and Sensitivity
  作者：Rong-Hua Yang、Wing-Hong Chan、Albert W. M. Lee、Ping-Fang Xia、Hong-Kui Zhang、L

  DOI：10.1021/ja029253d

  日期：2003.3.1

  A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene.