N-(3-chlorobenzyl)-4-methoxybenzenamine | 93642-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-chlorobenzyl)-4-methoxybenzenamine
• 英文别名: N-(3-chlorobenzyl)-4-methoxyaniline；N-[(3-Chlorophenyl)methyl]-4-methoxyaniline
• CAS: 93642-39-8
• 化学式: C₁₄H₁₄ClNO
• mdl: MFCD11058243
• 分子量: 247.724
• InChiKey: MNUBMWXSNXSGHM-UHFFFAOYSA-N

物化性质

• 沸点：
  376.9±27.0 °C(Predicted)
• 密度：
  1.205±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯苯乙烯 在 sodium acetate 、 palladium diacetate 、 iron(II) chloride 作用下， 以 乙腈 为溶剂， 反应 22.0h， 生成 N-(3-chlorobenzyl)-4-methoxybenzenamine
  参考文献：
  名称：

  4-羟基丁苯与芳基叠氮化物的铁催化硝基转移反应：通过C═C键裂解合成亚胺。

  摘要：

  打破C bondC债券以获取C═N债券的领域仍然不发达。报道了一种在非氧化条件下通过4-羟基苯乙烯与芳基叠氮化物的铁催化的腈转移反应产生亚胺的烯烃的C═C键裂解的新方案。各种顺序一锅法反应的成功表明，该方法的良好兼容性使其对于合成应用非常有吸引力。在实验观察的基础上，还提出了合理的反应机理。

  DOI：

  10.1021/acs.orglett.9b03160

文献信息

• Carbon monoxide-driven osmium catalyzed reductive amination harvesting WGSR power
  作者：Klim O. Biriukov、Mikhail M. Vinogradov、Oleg I. Afanasyev、Dmitry V. Vasilyev、Alexey A. Tsygankov、Maria Godovikova、Yulia V. Nelyubina、Dmitry A. Loginov、Denis Chusov

  DOI：10.1039/d1cy00695a

  日期：——

  First osmium-catalyzed reductive amination under the water gas–shift reaction conditions was developed. Proposed catalytic system demonstrates high performance even at the catalyst loading as low as 0.0625 mol%.

  首次在水煤气转移反应条件下开发了铂催化的还原胺化反应。提出的催化体系表现出高性能，即使在催化剂负载量仅为0.0625 mol% 时也是如此。
• Brønsted Acid Catalyzed Reductive Amination with Benzothiazoline as a Highly Efficient Hydrogen Donor
  作者：Takahiko Akiyama、Chen Zhu

  DOI：10.1055/s-0030-1260539

  日期：2011.6

  Reductive amination of aldehyde and amine proceeded smoothly in the presence of benzothiazoline as efficient hydrogen source by means of 20 mol% trifluoroacetic acid to give the corresponding amines in excellent yields. Hydrogen-donor abilities of benzothiazoline, benzimidazoline, and benzoxazoline were compared.

  醛和胺的还原胺化反应在苯并噻唑啉作为高效氢源的存在下顺利进行，并借助20摩尔%的三氟乙酸，以优异的产率得到了相应的胺。比较了苯并噻唑啉、苯并咪唑啉和苯并噁唑啉的供氢能力。
• Fluoran compounds
  申请人：HODOGAYA CHEMICAL CO., LTD.

  公开号：EP0115821A1

  公开（公告）日：1984-08-15

  A 2-(chloro-substituted benzylamino)-6-dibutylamino- fluoran compound represented by the general formula:

  一种由通式表示的 2-(氯代苄基氨基)-6-二丁氨基-芴化合物：
• Molecular iodine catalyzed transfer hydrogenation: reduction of aldimines, ketimines, and α-imino esters
  作者：Prabhakar Bachu、Chen Zhu、Takahiko Akiyama

  DOI：10.1016/j.tetlet.2013.05.071

  日期：2013.7

  An efficient and practical protocol for the reduction of aldimines, ketimines, and alpha-imino esters in the presence of catalytic amount of molecular iodine with Hantzsch ester at ambient temperature afforded the corresponding amines in excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.
• Transfer hydrogenation of imines with carboxyl-tailed benzothiazoline as readily removable hydrogen donor
  作者：Chen Zhu、Takahiko Akiyama

  DOI：10.1016/j.tetlet.2011.11.061

  日期：2012.1

  A benzothiazoline bearing 4-carboxyphenyl group at 2-position was developed as an efficient hydrogen donor for the transfer hydrogenation reaction. Introduction of the carboxyl group significantly facilitated the removal of the residual benzothiazoline and benzothiazole by washing with aqueous basic solution. The present approach provides a convenient and straightforward access to various amines with broad substrate scope and in good yields. (C) 2011 Elsevier Ltd. All rights reserved.