2-Phenoxi-trifluormethansulfonanilid | 37930-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Phenoxi-trifluormethansulfonanilid
• 英文别名: 1,1,1-trifluoro-N-(2-phenoxyphenyl)methanesulfonamide
• CAS: 37930-65-7
• 化学式: C₁₃H₁₀F₃NO₃S
• 分子量: 317.289
• InChiKey: ISWJZEVICKUFBE-UHFFFAOYSA-N

物化性质

• 沸点：
  340.3±52.0 °C(Predicted)
• 密度：
  1.462±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  苯酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-Phenoxi-trifluormethansulfonanilid
  参考文献：
  名称：

  Antiinflammatory fluoroalkanesulfonanilides. 3. Other fluoroalkanesulfonamido diaryl systems

  摘要：

  A series of isosteres of 3-benzoyltrifluoromethanesulfonanilide involving alternatives to the carbonyl linking group was synthesized and screened for antiinflammatory activity in the carrageenan rat paw edema test. The systems examined were of the type m-CF3SO2NH-C6H4-X-C6H5, where X was -CROH-, -CHR-, -CH(OH)CH2-, -COCH2-, -CH2CO-, greater than C equal to CR2, -CR equal to CH, -C identical to C-, -CH2CH2-, CONH-, -NR-, -O-, -S(O)n- (n equal to 0,1,2), and carbon-carbon single bond. Many ortho and para derivatives were also tested. Several of these new trifluoromethanesulfonanilides proved equipotent with phenylbutazone. The effects on the anticarrageenan activity of both the nature and ring position of X are discussed.

  DOI：

  10.1021/jm00238a013

文献信息

• N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES
  申请人：Winzenberg Norman Kevin

  公开号：US20070238700A1

  公开（公告）日：2007-10-11

  Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.

  提供了一种用于控制环境中内外寄生虫的新型N-苯基-1,1,1-三氟甲磺酰胺化合物，以及制备这些化合物的方法，以及利用这些创新化合物治疗体内和体外寄生虫感染的方法。
• Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
  申请人：Meyer Gerhard Adam

  公开号：US20060063841A1

  公开（公告）日：2006-03-23

  Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.

  提供了一种新型三氟甲磺酰苯胺肟醚化合物，可用于控制环境中的内寄生虫和/或外寄生虫，同时提供了制备这些化合物的方法，以及利用这些创新化合物治疗体内或体外寄生虫感染的方法。
• CARBONATES OF FENICOL ANTIBIOTICS
  申请人：Glinka Tomasz W.

  公开号：US20070155799A1

  公开（公告）日：2007-07-05

  Novel fenicol compounds having useful properties as antibiotic prodrugs, are provided, together with methods of making and using these new compounds.

  提供了具有作为抗生素前药有用特性的新颖费诺酮化合物，以及制备和使用这些新化合物的方法。
• [EN] PYRIDINE AND PYRIMIDINE COMPOUNDS FOR CONTROLLING INVERTEBRATE<br/>[FR] COMPOSÉS DE PYRIDINE ET DE PYRIMIDINE UTILISÉS POUR LUTTER CONTRE DES NUISIBLES INVERTÉBRÉS
  申请人：DU PONT

  公开号：WO2012087630A1

  公开（公告）日：2012-06-28

  Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein A is N or CR3; R1, R2, R3, R4, R5 and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  本文披露了Formula 1的化合物、N-氧化物及其盐，其中A为N或CR3；R1、R2、R3、R4、R5和Q如披露中所定义。还披露了含有Formula 1化合物的组合物，以及用于控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与本发明的化合物或组合物的生物有效量接触。
• [EN] HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR USE IN THE TREATMENT HELMINTH INFECTION<br/>[FR] COMPOSÉS HÉTÉROARYLES À UNITÉ DE PONTAGE CYCLIQUE UTILISÉS DANS LE TRAITEMENT D'INFECTIONS HELMINTHIQUES
  申请人：INTERVET INT BV

  公开号：WO2013144180A1

  公开（公告）日：2013-10-03

  This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环烯基化合物，用作药物，更具体地用作治疗动物的药物。该药物可用于治疗蠕虫感染和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及利用这些化合物制备药物和治疗方法，包括将这些化合物给予需要治疗的动物。本发明还涉及包含这些化合物的药物组合物和配套工具。