1-(1H-Imidazole-1-carbonyl)pyrrolidin-2-one | 143150-77-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(1H-Imidazole-1-carbonyl)pyrrolidin-2-one
• 英文别名: 1-(imidazole-1-carbonyl)pyrrolidin-2-one
• CAS: 143150-77-0
• 化学式: C₈H₉N₃O₂
• 分子量: 179.18
• InChiKey: VRUKIFVDFLEAFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Carbamoyl-2-pyrrolidinone compounds
  申请人：TAIHO PHARMACEUTICAL COMPANY, LIMITED

  公开号：EP0373226A1

  公开（公告）日：1990-06-20

  Carbamoyl-2-pyrrolidinone compounds quite useful as an agent for treating senile dementia, or improving brain functions, or activating and protecting brain metabolism, which are represented by formula (2) (wherein R1 represents a hydrogen atom, a hydroxy group or an optionally hydroxy-substituted lower alkyl group, R3 represents a phenyl, tetrahydronaphthyl, pyridyl or thiazolyl group optionally substituted by a lower alkoxy group, a lower alkylamino group, a halogen atom or a halogenomethyl group) are disclosed. Also disclosed are novel carbamoyl-2-pyrrolidinone compounds represented by general formula (1), wherein R1 represents a hydrogen atom, a hydroxy group or an optionally hydroxy-substituted lower alkyl group, and R2 represents a phenyl, tetrahydronaphthyl, pyridyl or thiazolyl group optionally having a methoxy group or a lower alkylamino group as a substituent, provided that R2 does not represents an unsubstituted phenyl group when R1 represents a hydrogen atom or an unsubstituted lower alkyl group.

  本发明公开了由式（2）代表的氨基甲酰基-2-吡咯烷酮化合物（其中 R1 代表氢原子、羟基或任选被羟基取代的低级烷基，R3 代表任选被低级烷氧基、低级烷氨基、卤原子或卤代甲基取代的苯基、四氢萘基、吡啶基或噻唑基）。还公开了通式（1）代表的新型氨基甲酰基-2-吡咯烷酮化合物，其中 R1 代表氢原子、羟基或任选被羟基取代的低级烷基，R2 代表任选被甲氧基或低级烷基氨基取代的苯基、四氢萘基、吡啶基或噻唑基，条件是当 R1 代表氢原子或未取代的低级烷基时，R2 不代表未取代的苯基。
• US5229402A
  申请人：——

  公开号：US5229402A

  公开（公告）日：1993-07-20
• US5447944A
  申请人：——

  公开号：US5447944A

  公开（公告）日：1995-09-05