3,4-diallylbenzene-1,2-diol | 50916-58-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,4-diallylbenzene-1,2-diol
• 英文别名: 3,4-bis(prop-2-enyl)benzene-1,2-diol
• CAS: 50916-58-0
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: BUUFRRYYYJLJGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-diallylbenzene-1,2-diol 生成 3,4-bis(prop-2-enyl)cyclohexa-3,5-diene-1,2-dione
  参考文献：
  名称：

  LIAO, C. C.;LIN, H. S.;LIN, J. T., J. CHIN. CHEM. SOC., 1980, 27, N 3, 87-95

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-二(烯丙氧基)苯 在 phosphomolybdic acid 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.33h， 生成 3,4-diallylbenzene-1,2-diol 、 3,6-diallylbenzene-1,2-diol
  参考文献：
  名称：

  研究微波加速烯丙基芳基醚的克莱森重排：催化剂，溶剂，温度和底物的范围

  摘要：

  对微波加速烯丙基芳基醚的克莱森重排进行了研究，以便深入了解催化剂，溶剂，温度和底物的范围。在所考察的催化剂中，发现磷钼酸（PMA）在220至300°C的温度下可大大促进NMP中的反应。发现该方法对于使用贵金属催化剂例如Au（I），Ag（I）和Pt（II）制备先前在文献中报道的几种中间体是有用的。另外，在芳基部分带有溴和硝基的底物需要仔细调整反应条件，以避免复杂的产物分布。

  DOI：

  10.1016/j.tetlet.2020.151995

文献信息

• SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA
  申请人：Bandyopadhyay Santu

  公开号：US20140135393A1

  公开（公告）日：2014-05-15

  The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

  本发明涉及通式1的化合物，用于通过抑制IL-4或IL-5途径的抑制治疗支气管哮喘。本发明还涉及使用通式1的化合物通过抑制IL-4或IL-5途径的抑制治疗支气管哮喘。本发明还涉及通过口服、鼻内、或吸入途径向需要治疗的哺乳动物给予化合物或所述组合物来抑制IL-4或IL-5途径以治疗哮喘的方法。通式1的化合物可用于减少周围血管和支气管炎症。
• [EN] INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO)<br/>[FR] INHIBITEURS DE LA PHOSPHATIDYLINOSITOL-3-KINASE (PI3) ET INDUCTEURS D'OXYDE NITRIQUE (NO)
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010079423A1

  公开（公告）日：2010-07-15

  The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

  本发明涉及通式1的化合物，通过抑制PI3-Akt通路和/或诱导NO来治疗恶性肿瘤。本发明还涉及使用通式1的化合物通过抑制PI3-Akt通路和/或诱导NO来治疗恶性肿瘤。本发明还涉及通过向需要该治疗的哺乳动物给予该化合物或该组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。
• INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO)
  申请人：Bandyopadhyay Santu

  公开号：US20120190738A1

  公开（公告）日：2012-07-26

  The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

  本发明涉及一般式I的化合物，通过抑制PI3-Akt途径和/或诱导NO治疗恶性肿瘤。本发明还涉及使用一般式I的化合物通过抑制PI3-Akt途径和/或诱导NO治疗恶性肿瘤。本发明还涉及一种通过向需要该治疗的哺乳动物给予化合物或所述组合物来抑制PI3-Akt途径和/或诱导NO治疗恶性肿瘤的方法。
• Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma
  申请人：Bandyopadhyay Santu

  公开号：US09302967B2

  公开（公告）日：2016-04-05

  The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

  本发明涉及一般式1的化合物，通过抑制IL-4或IL-5途径的抑制作用治疗支气管哮喘。本发明还涉及使用一般式1的化合物通过抑制IL-4或IL-5途径的抑制作用治疗支气管哮喘。本发明还涉及通过口服、鼻内、或吸入途径向需要治疗的哺乳动物给予化合物或该组合物抑制IL-4或IL-5途径来治疗哮喘的方法。一般式1的化合物可用于减轻血管周围和支气管周围的炎症。
• Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs
  作者：Anushree Achari、Sourav Chatterjee、Sudip Dey、Tapas K. Kundu、Parasuraman Jaisankar

  DOI：10.1039/d2ob02081e

  日期：——

  Biocatalysis plays an important role in the synthesis of complex organic molecules. Wedelolactone, a natural coumestan, has been reported to have many bioactive properties. A novel and efficient enzyme obtained from sweet potato juice was used for condensation of 4-hydroxycoumarins with catechols to produce wedelolactone and its structurally diverse analogs in moderate to good yields under mild reaction

  生物催化在复杂有机分子的合成中起着重要作用。据报道，Wedelolactone 是一种天然香豆素，具有许多生物活性。一种从红薯汁中获得的新型高效酶用于 4-羟基香豆素与儿茶酚的缩合，在温和的反应条件下以中等到良好的产率生产葶苈内酯及其结构多样的类似物。因此，这种酶促方法创造了获得许多基于香豆素的化合物的机会，这些化合物是合成药学上重要分子的潜在组成部分。