1-phenyl-4-phthalimidylbutanol | 121883-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-4-phthalimidylbutanol
• 英文别名: 2-(4-Hydroxy-4-phenylbutyl)isoindole-1,3-dione
• CAS: 121883-30-5
• 化学式: C₁₈H₁₇NO₃
• 分子量: 295.338
• InChiKey: QACFXXVBZXBMMD-UHFFFAOYSA-N

物化性质

• 沸点：
  488.1±38.0 °C(Predicted)
• 密度：
  1.272±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-phenylbutyl)isoindoline-1,3-dione 在 ammonium sulfide 、 N-羟基邻苯二甲酰亚胺 、 ammonium cerium (IV) nitrate 、 水 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 1.0h， 生成 1-phenyl-4-phthalimidylbutanol
  参考文献：
  名称：

  Direct oxidative installation of nitrooxy group at benzylic positions and its transformation into various functionalities

  摘要：

  C-H Nitrooxylation at benzylic positions has been achieved by employing the N-hydroxyphthalimide (NHPI) catalyst/cerium(IV) ammonium nitrate (CAN) reagent system. The nitrooxy groups were demonstrated to function as tentative hydroxy protecting groups, as well as excellent leaving groups for N- and C-substitution reactions. Hence, the present method offers a unique way to synthesize diverse O-. N-, or C-functionalized benzylic compounds from simple alkyl aromatics. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.118

文献信息

• 1,2-ADDITION OF A FUNCTIONALIZED ZINC-COPPER ORGANOMETALLIC [RCu(CN)ZnI] TO AN a,b-UNSATURATED ALDEHYDE: (E)-2-(4-HYDROXY-6-PHENYL-5-HEXENYL)-1H-ISOINDOLE-1,3(2H)-DIONE
  作者：Yeh, Ming Chang P.、Chen, Huai Gu、Knochel, Paul

  DOI：10.15227/orgsyn.070.0195

  日期：——
• The reaction of the highly functionalized copper reagents RCu(CN)ZnI.BF3 with aldehydes
  作者：Ming Chang P. Yeh、Paul Knochel、Leroy E. Santa

  DOI：10.1016/s0040-4039(00)80372-x

  日期：1988.1
• YEH, MING CHANG P.;KNOCHEL, PAUL;SANTA, LEROY E., TETRAHEDRON LETT., 29,(1988) N 32, C. 3887-3890
  作者：YEH, MING CHANG P.、KNOCHEL, PAUL、SANTA, LEROY E.

  DOI：——

  日期：——
• Direct oxidative installation of nitrooxy group at benzylic positions and its transformation into various functionalities
  作者：Shin Kamijo、Yuuki Amaoka、Masayuki Inoue

  DOI：10.1016/j.tetlet.2011.06.118

  日期：2011.9

  C-H Nitrooxylation at benzylic positions has been achieved by employing the N-hydroxyphthalimide (NHPI) catalyst/cerium(IV) ammonium nitrate (CAN) reagent system. The nitrooxy groups were demonstrated to function as tentative hydroxy protecting groups, as well as excellent leaving groups for N- and C-substitution reactions. Hence, the present method offers a unique way to synthesize diverse O-. N-, or C-functionalized benzylic compounds from simple alkyl aromatics. (C) 2011 Elsevier Ltd. All rights reserved.