(S)-2,2'-bis[bis(2-naphthyl)phosphino]-1,1'-binaphthyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2,2'-bis[bis(2-naphthyl)phosphino]-1,1'-binaphthyl
• 英文别名: [1-(2-Dinaphthalen-2-ylphosphanylnaphthalen-1-yl)naphthalen-2-yl]-dinaphthalen-2-ylphosphane
• 化学式: C₆₀H₄₀P₂
• 分子量: 822.925
• InChiKey: FQIKYPCMPUCFSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.4
• 重原子数：
  62
• 可旋转键数：
  7
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (S)-2,2'-bis[bis(2-naphthyl)phosphino]-1,1'-binaphthyl 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 [(R-BINAP^naph)PdMe(MeCN)]BF₄
  参考文献：
  名称：

  Synthesis and photocatalytic activity of a naphthyl-substituted photosensitizing BINAP–palladium complex

  摘要：

  一种新型的光活性Pd配合物，其配体为具有2-萘基取代基的BINAP配体，已经被合成和表征，该配合物在催化光控制的4-甲氧基苯乙烯聚合反应中表现出活性。

  DOI：

  10.1039/c5dt04228c
• 作为产物：
  描述：

  (S)-2-di(2-naphthyl)phosphinyl-2'-di(2-naphthyl)phosphino-1,1'-binaphthyl 在 盐酸 、 sodium hydroxide 、 三氯硅烷 、 2,3-二甲基苯胺 作用下， 以 水 、 甲苯 为溶剂， 以87%的产率得到(S)-2,2'-bis[bis(2-naphthyl)phosphino]-1,1'-binaphthyl
  参考文献：
  名称：

  Method for producing optically active diphosphine compounds

  摘要：

  本发明提供了一种生产新型光学活性双膦化合物（即2,2'-双（二取代磷基）-1,1'-联萘化合物）的方法，具有不同于传统BINAP化合物的选择性（化学选择性或对映选择性）和催化活性。在本发明的一种生产光学活性双膦化合物（即2,2-双（二取代磷基）-1,1'-联萘基）的方法中，在过渡金属-膦配合物的存在下，将2,2'-双（三氟甲磺氧基）-1,1'-联萘与下列通式所表示的膦氧化合物反应：A.sub.2 P(O)H，其中A代表苯基；一至三取代的苯基，其中取代基在取代苯基中各自从卤素原子，低碳基，低烷氧基或低卤代烷氧基组成，以便一个或多个取代基可以相同或不同；萘基；低烷基萘基；或低烷氧基萘基。

  公开号：

  US05693868A1

文献信息

• Method for making an optically active diphosphine ligand
  申请人：Takasago International Corporation

  公开号：US05922918A1

  公开（公告）日：1999-07-13

  The present invention provides a method for making compound (1) by reacting compound (2) with phosphine oxide (3) in the presence of a transition metal/phosphine complex and optionally reducing the reaction product: ##STR1## where n represents 0 or 1; the double line having a continuous line and a dotted line represents a double bond or a single bond such that the ring having the double line forms a naphthalene ring or an octahydronaphthalene ring with an adjacent benzene ring; Tf represents a trifluoromethanesulfonyl group; and Ar represents a phenyl group, a substituted phenyl group or a naphthyl group. The present invention provides an economical way to produce compound (1) as a ligand of a complex useful as a catalyst for a variety of asymmetric synthesis reactions.

  本发明提供了一种制备化合物（1）的方法，通过在过渡金属/膦配合物存在下，将化合物（2）与膦氧化物（3）反应，并可选择性地还原反应产物：其中n代表0或1；具有连续线和虚线的双线代表双键或单键，使具有双线的环形成一个萘环或与相邻苯环形成一个八氢萘环；Tf代表三氟甲磺酰基；Ar代表苯基，取代苯基或萘基。本发明提供了一种经济的方法，用作多种不对称合成反应的催化剂的复合物的配体，以生产化合物（1）。
• Process for preparation of diphosphine compounds and intermediates for the process
  申请人：Goto Mitsutaka

  公开号：US20050027124A1

  公开（公告）日：2005-02-03

  A production method of a compound represented by the formula wherein R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 2a , R 2b , R 2c , R 2d , R 2e an R 2f are the same or different and each is a hydrogen atom and the like, and R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.

  提供一种化合物的生产方法，该化合物的化学式为其中R1a，R1b，R1c，R1d，R1e，R1f，R2a，R2b，R2c，R2d，R2e和R2f相同或不同，每个都是氢原子等，R3，R4，R5，R6，R7，R8，R9和R10相同或不同，每个都是氢原子等，或其盐，包括在存在胺和镍催化剂的溶剂中，将化学式为其中X是离去基团，其他符号如上所定义的化合物或其盐与化学式为其中符号如上所定义的膦硼烷复合物或其盐反应。
• Process for Preparation of Diphosphine Compounds and Intermediates for the Process
  申请人：Goto Mitsutaka

  公开号：US20070161805A1

  公开（公告）日：2007-07-12

  A production method of a compound represented by the formula wherein R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 2a , R 2b , R 2c , R 2d , R 2e and R 2f are the same or different and each is a hydrogen atom and the like, and R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.

  提供一种化合物的生产方法，该化合物的化学式表示为： 其中，R1a、R1b、R1c、R1d、R1e、R1f、R2a、R2b、R2c、R2d、R2e和R2f相同或不同，每个都是氢原子等，R3、R4、R5、R6、R7、R8、R9和R10相同或不同，每个都是氢原子等，或其盐。该方法包括在胺和镍催化剂的存在下，在溶剂中将下列化合物： 其中，X是离去基团，其他符号如上定义，或其盐，与下列膦硼烷复合物反应： 其中，符号如上定义，或其盐。
• PROCESS FOR THE REDUCTION OF A TERTIARY PHOSPHINE OXIDE TO THE CORRESPONDING TERTIARY PHOSPHINE IN THE PRESENCE OF A CATALYST AND USE OF A TERTIARY PHOSPHINE FOR REDUCING A TERTIARY PHOSPHINE OXIDE IN THE PRESENCE OF A CATALYST
  申请人：Laven Gaston

  公开号：US20130012725A1

  公开（公告）日：2013-01-10

  A process for the conversion of a tertiary phosphine oxide to the corresponding tertiary phosphine includes reacting the tertiary phosphine oxide with a reducing tertiary phosphine, in the presence of a catalyst that catalyzes the conversion.

  将三级膦氧化物转化为相应的三级膦的过程包括在催化剂的存在下，将三级膦氧化物与还原三级膦反应，催化剂催化转化。
• Ruthenium-optically active phosphine complex, process for the preparation thereof and process for the preparation of optically active 4-methyl-2-oxetanone using same
  申请人：Takasago International Corporation

  公开号：EP0841343A2

  公开（公告）日：1998-05-13

  The present invention provides a catalyst which exhibits a high catalytic activity and allows asymmetric reaction in a high asymmetric yield to obtain a reaction product having a high optical purity. The present invention also provides a process for the preparation of an optically active 4-methyl-2-oxetanone having a high optical purity useful as starting material of polymer in a high yield in a short period in the presence of the foregoing catalyst. A novel ruthenium-iodo-optically active phosphine complex is provided, represented by the following general formula (1):         Ru-I2-(R1-BINAP)     (1) wherein R1-BINAP represents an optically active tertiary phosphine represented by the following general formula (2): wherein R1 represents an aryl group which may have a substituent selected from the group consisting of a C1-4 lower alkyl group, a C1-4 lower alkoxy group, a C1-4 lower alkylamino group, and a halogen atom or a C3-8 cycloalkyl group.

  本发明提供了一种催化剂，该催化剂具有很高的催化活性，能够以很高的不对称产率进行不对称反应，从而获得光学纯度很高的反应产物。本发明还提供了一种制备具有高光学纯度的光学活性 4-甲基-2-氧杂环丁酮的工艺，这种光学活性 4-甲基-2-氧杂环丁酮可作为聚合物的起始原料，在上述催化剂存在下，可在短时间内获得高产率。本发明提供了一种新型钌-碘光学活性膦配合物，其通式如下（1）： Ru-I2-(R1-BINAP) (1) 其中 R1-BINAP 代表由以下通式（2）表示的光学活性叔膦： 其中 R1 代表芳基，该芳基可具有选自 C1-4 低级烷基、C1-4 低级烷氧基、C1-4 低级烷氨基、卤素原子或 C3-8 环烷基的取代基。