2-(3-chlorophenylcarbamoyl)phenyl acetate | 405146-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-chlorophenylcarbamoyl)phenyl acetate
• 英文别名: [2-[(3-Chlorophenyl)carbamoyl]phenyl] acetate
• CAS: 405146-65-8
• 化学式: C₁₅H₁₂ClNO₃
• 分子量: 289.718
• InChiKey: RCWCOWODWAKYCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氯苯胺 、 邻乙酰水杨酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以27%的产率得到2-(3-chlorophenylcarbamoyl)phenyl acetate
  参考文献：
  名称：

  Synthesis and Activity of Novel Fungicide 2-(3-Chlorophenylcarbamoyl)phenyl Acetate

  摘要：

  本研究通过氨解 2-(氯羰基)苯基乙酸酯合成了 2-(3-氯苯基氨基甲酰基)苯基乙酸酯。红外光谱和 1H NMR 证实了其结构。在实验室中测定了它对 Sclerotinia sclerotiorum 和 Helminthosprium maydis 的抗真菌活性。结果表明，它对这两种不同的植物病原真菌具有良好的抗真菌活性。其有效浓度中值（EC50）分别达到 2 毫克/升和 3.80 毫克/升。

  DOI：

  10.14233/ajchem.2015.17833

文献信息

• Optimization and Antifungal Activity of Amide Analogues
  作者：Hui Feng、Li Leng、Jia Liu、Yuanmou Tang、Pengcheng Tang、Chixiang Zhang、Xioarong Tang、Shirong Jiao

  DOI：10.14233/ajchem.2013.13895

  日期：——

  Using salicylic acid as a lead compound, a series of its analogues (compounds 1-16) were designed and synthesized. Their activity of anti-pathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had certain antifungal activity against Sclerotinia sclerotiorum and Bipolaris maydis (Nisikado et Miyake) Shoem. Among them, the inhibition of growth for 2-(3-fluorophenylcarbamoyl)phenyl acetate (1) and 2-(3-chlorophenylcarbamoyl)phenyl acetate (2) reached 91.1 %, 92.8 % and 90.1 %, 90.1 % at a concentration of 100 mg L-1, respectively.

  以水杨酸为先导化合物，设计并合成了一系列水杨酸类似物（化合物 1-16）。在实验室中对其抗植物病原真菌的活性进行了评估。结果表明，这些化合物对 Sclerotinia sclerotiorum 和 Bipolaris maydis (Nisikado et Miyake) Shoem 具有一定的抗真菌活性。其中，2-(3-氟苯基氨基甲酰基)苯基乙酸酯（1）和 2-(3-氯苯基氨基甲酰基)苯基乙酸酯（2）在 100 mg L-1 浓度下的生长抑制率分别达到 91.1 %、92.8 % 和 90.1 %、90.1 %。
• Synthesis and Activity of Novel Fungicide 2-(3-Chlorophenylcarbamoyl)phenyl Acetate
  作者：Chixiang Zhang、Zhou Wang、Bo Pu、Xuesong Wang、Shirong Jiao

  DOI：10.14233/ajchem.2015.17833

  日期：——

  In the present study, 2-(3-chlorophenylcarbamoyl)phenyl acetate was synthesized by the ammonolysis of 2-(chlorocarbonyl)phenyl acetate. Its structure was confirmed by IR and 1H NMR. Its antifungal activity against Sclerotinia sclerotiorum and Helminthosprium maydis has been determined in the laboratory. The results showed that it had good antifungal activity against the two different pathogenic fungi of plants. Its median effective concentrations (EC50) reached 2 and 3.80 mg L-1, respectively.

  本研究通过氨解 2-(氯羰基)苯基乙酸酯合成了 2-(3-氯苯基氨基甲酰基)苯基乙酸酯。红外光谱和 1H NMR 证实了其结构。在实验室中测定了它对 Sclerotinia sclerotiorum 和 Helminthosprium maydis 的抗真菌活性。结果表明，它对这两种不同的植物病原真菌具有良好的抗真菌活性。其有效浓度中值（EC50）分别达到 2 毫克/升和 3.80 毫克/升。