联苯-4-甲醛缩氨基硫脲 | 100708-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 联苯-4-甲醛缩氨基硫脲
• 英文名称: (E)-2-([1,1'-biphenyl]-4-ylmethylene)hydrazinecarbothioamide
• 英文别名: biphenyl-4-carbaldehyde-thiosemicarbazone；Biphenyl-4-carbaldehyd-thiosemicarbazon；{[(4-Phenylphenyl)methylidene]amino}thiourea；[(E)-(4-phenylphenyl)methylideneamino]thiourea
• CAS: 100708-37-0
• 化学式: C₁₄H₁₃N₃S
• 分子量: 255.343
• InChiKey: ZGTAYOMAARHFLW-MHWRWJLKSA-N

物化性质

• 熔点：
  205 °C(Solv: ethanol (64-17-5))
• 沸点：
  428.1±38.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氨基硫脲 、 对苯基苯甲醛 以 乙醇 、 水 为溶剂， 以70%的产率得到联苯-4-甲醛缩氨基硫脲
  参考文献：
  名称：

  芳基硫代半氨基甲酮类药物治疗锥虫病感染

  摘要：

  基于显示出抗锥虫病活性的噻二唑衍生物库，我们已经考虑了噻二唑的开放形式和反应中间体硫代半脲类化合物，作为针对布鲁氏锥虫（Tb），婴儿利什曼原虫（Li）和克氏锥虫（Tc）。相似的化合物已经显示出对相同生物的有趣活性。该化合物对T. brucei和T. cruzi特别有效。在这28种合成的化合物中，最好的一种是（E）-2-（4-（（3.4-二氯苄基）氧基）亚苄基）肼基甲硫代酰胺（A14）针对三种寄生物（Tb EC 50  = 2.31μM，Li EC 50  = 6.14μM，Tc EC 50  = 1.31μM ）产生可比的抗寄生虫活性，并且相对于人类巨噬细胞的选择性指数高于10，因此显示泛抗锥虫病活动。（E）-2-（（（3'.4'-二甲氧基-[1.1'-联苯] -3-基]甲基）甲基）肼基甲硫代酰胺（A12）和（E）-2-（4-（（3.4-二氯苄基）氧基）苯亚甲基）肼硫代甲酰胺（A14）在组

  DOI：

  10.1016/j.ejmech.2018.01.043

文献信息

• Thiosemicarbazones as anti-virals and immunopotentiators
  申请人：Barsanti A. Paul

  公开号：US20050069555A1

  公开（公告）日：2005-03-31

  The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.

  本发明涉及新型免疫增强剂、新型疫苗佐剂、新型化合物和药物组合物、通过给予该化合物治疗包括HCV在内的病毒感染的新方法，以及通过给予该化合物调节免疫反应的新方法。
• METHODS FOR IDENTIFYING MODULATORS OF KINESIN ACTIVITY
  申请人：Rosetta Inpharmatics LLC.

  公开号：EP1629284A2

  公开（公告）日：2006-03-01
• METHODS FOR IDENTIFYING GENES THAT MEDIATE A RESPONSE OF A LIVING CELL TO AN AGENT
  申请人：Rosetta Inpharmatics LLC.

  公开号：EP1735464A2

  公开（公告）日：2006-12-27
• Methods for identifying modulators of kinesin activity
  申请人：Mao Mao

  公开号：US20070134660A1

  公开（公告）日：2007-06-14

  In a first aspect, the invention provides methods for screening for modulators of a target protein, comprising the steps of contacting a target protein with a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has more than 80% amino acid sequence identity to KIF14 (SEQ ID NO:2) or the KIF14 motor domain (SEQ ID NO:3). In a second aspect, the invention provides methods for modulating cell proliferation comprising administering to a cell an effective amount of a modulator of the activity of a target protein. Some embodiments of this aspect provide methods for treating a subject with a cellular hyperproliferation disorder, such as cancer. In a third aspect, the invention provides methods for identifying candidate subjects for treatment with an inhibitor of the activity of a target protein.
• Methods for Identifying Genes that Mediate a Response of a Living Cell to an Agent
  申请人：Mao Mao

  公开号：US20090004645A1

  公开（公告）日：2009-01-01

  In one aspect, the present invention provides methods for determining whether a gene mediates the response of a living cell to an agent. In another aspect, the present invention provides methods to identify a mammalian subject responsive to a KSP inhibitor.