3-methoxy-4-methylbenzenesulfonic acid | 7134-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methoxy-4-methylbenzenesulfonic acid
• 英文别名: 2-Methoxy-1-methyl-benzol-4-sulfonsaeure；2-methoxy-toluene-4-sulfonic acid；2-Methoxy-toluol-4-sulfonsaeure；o-Kresolmethylaether-sulfonsaeure-(5)
• CAS: 7134-16-9
• 化学式: C₈H₁₀O₄S
• 分子量: 202.231
• InChiKey: YICXBQCYAZSIEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methoxy-4-methylbenzenesulfonic acid 在 potassium permanganate 、 硫酸 、 水 、 potassium carbonate 、 sodium hydroxide 、 锌 、 三氯氧磷 作用下， 以 水 为溶剂， 反应 13.5h， 生成 2-甲氧基-4-(甲硫基)苯甲酸
  参考文献：
  名称：

  Synthesis of 2-Methoxy-4-(methylsulfanyl)benzoic Acid — An Intermediate Product in the Preparation of the Cardiotonic Drugs Sulmazole and Isomazole

  摘要：

  Readily available 4-methyl-3-nitrobenzenesulfonic acid and 2-methyl-5-nitrophenol were used to develop two alternative approaches to the synthesis of 2-methoxy-4-(methylsulfanyl)benzoic acid in total yields of 17% and 37%, respectively. The synthesis starting from 2-methyl-5-nitrophenol is more process-oriented and can be used in the resynthesis of Sulmazole and Isomazole.

  DOI：

  10.1134/s1070428019080062
• 作为产物：
  描述：

  2-甲基苯甲醚 在 硫酸 作用下， 生成 3-methoxy-4-methylbenzenesulfonic acid
  参考文献：
  名称：

  Bromwell, American Chemical Journal, 1897, vol. 19, p. 569

  摘要：

  DOI：

文献信息

• [EN] PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS DE PLADIÉNOLIDE PYRIDINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2015175594A1

  公开（公告）日：2015-11-19

  The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.

  本发明提供了新型的pladienolide pyridine化合物，其中包括含有这些化合物的制药组合物，以及使用这些化合物作为治疗剂的方法。这些化合物可能在治疗癌症方面有用，特别是那些已知靶向剪接体和其中的突变体的治疗剂在这些癌症中被认为是有用的。
• Ink Composition, and Ink Jet Recording Method and Recorded Matter Using the Same
  申请人：Hanmura Masahiro

  公开号：US20080047461A1

  公开（公告）日：2008-02-28

  Problem: To improve clogging and ink droplet deflection. Solving Means: An ink composition comprising at least water, a colorant and an aromatic compound having a carboxyl group, which contains at least one member selected from the group consisting of a sodium ion, a potassium ion and an ammonium ion and also contains a lithium ion. Alternatively, an ink composition comprising at least water, a specific cyan dye and an aromatic compound having a carboxyl group, which contains a lithium ion and also contains a sodium ion and/or a potassium ion.

  问题：改善堵塞和墨滴偏转。 解决方法：一种油墨组合物，包括至少水、一种色料和一种含有羧基的芳香化合物，其中包含从钠离子、钾离子和铵离子组成的群体中选择的至少一种成员，同时还含有锂离子。或者，一种油墨组合物，包括至少水、一种特定的青色染料和一种含有羧基的芳香化合物，其中包含锂离子，同时还含有钠离子和/或钾离子。
• BET-PROTEIN-INHIBITING DIHYDROPYRIDOPYRAZINONES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160193206A1

  公开（公告）日：2016-07-07

  The present invention relates to BET protein-inhibitory, especially BRD4-inhibitory, dihydropyridopyrazinones of the general formula (I) in which A, X, R 1 , R 2 , R 3 , R 4 , R 4 , R 6 , R 7 and n have the meanings given in the description, to intermediates for preparation of the compounds according to the invention, to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of neoplastic disorders. This invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.

  本发明涉及BET蛋白抑制剂，特别是BRD4抑制剂，通式（I）所示的二氢吡啶吡唑酮，其中A、X、R1、R2、R3、R4、R4、R6、R7和n在说明书中给出其含义，以及制备本发明化合物的中间体，包含本发明化合物的制药组合物，以及在高增殖性疾病，特别是恶性肿瘤疾病的预防和治疗中的预防和治疗用途。本发明还涉及在病毒感染、神经退行性疾病、炎症性疾病、动脉粥样硬化性疾病和男性生育控制中使用BET蛋白抑制剂。
• Method of monitoring a parameter of a hydrocarbon well, pipeline or formation
  申请人：JOHNSON MATTHEY PUBLIC LIMITED COMPANY

  公开号：US10365262B2

  公开（公告）日：2019-07-30

  A method of monitoring a parameter of a hydrocarbon well, pipeline or formation is provided. The method comprises introducing a tracer into the hydrocarbon well, pipeline or formation; producing a fluid from the hydrocarbon well, pipeline or formation; and analyzing the fluid to determine if the tracer is present in the fluid. The tracer comprises a halogenated alkoxylated-benzoic acid, an alkoxylated benzene sulfonic acid, a salt of a halogenated alkoxylated-benzoic acid or a salt of an alkoxylated benzene sulfonic acid.

  提供了一种监测碳氢化合物井、管道或地层参数的方法。该方法包括将示踪剂引入烃井、管道或地层；从烃井、管道或地层中产生流体；分析流体以确定流体中是否存在示踪剂。示踪剂包括卤代烷氧基化苯甲酸、烷氧基化苯磺酸、卤代烷氧基化苯甲酸的盐或烷氧基化苯磺酸的盐。
• 321. Thiols derived from o-, m-, and p-methoxy-toluenes and -benzoic acids
  作者：Madhavlal S. Shah、Chinubhai T. Bhatt、Darab D. Kanga

  DOI：10.1039/jr9330001375

  日期：——