(3,5-bis(trifluoromethyl)phenyl)hydrazine hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-bis(trifluoromethyl)phenyl)hydrazine hydrochloride
• 英文别名: 3,5-ditrifluoromethylphenylhydrazine hydrochloride；[3,5-Bis(trifluoromethyl)anilino]azanium;chloride
• 化学式: C₈H₆F₆N₂*ClH
• mdl: MFCD03094165
• 分子量: 280.6
• InChiKey: OPIOKSFIERNABH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.12
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (3,5-bis(trifluoromethyl)phenyl)hydrazine hydrochloride 在 水 、 sodium hydroxide 作用下， 以 乙酸乙酯 为溶剂， 反应 0.5h， 以200.2 g的产率得到3,5-双(三氟甲基)苯肼
  参考文献：
  名称：

  HETEROARYL COMPOUNDS FOR THE TREATMENT OF OPHTHALMIC DISEASES

  摘要：

  公开号：

  EP3210973B1
• 作为产物：
  描述：

  间二(三氟甲基)苯胺 生成 (3,5-bis(trifluoromethyl)phenyl)hydrazine hydrochloride
  参考文献：
  名称：

  HOLAN, G.

  摘要：

  DOI：

文献信息

• WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS
  申请人：COOPER EDWARD MICHAEL

  公开号：US20060239922A1

  公开（公告）日：2006-10-26

  Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 R 11 , R 12 , R 13 and R 14 is -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 comprises fluorine. The use of cyanine dyes substituted by fluorine and having additional substitution with three or more sulphonic acid groups for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions. The dyes of the present invention are particularly useful in assays involving fluorescence detection where continual or repeated excitation is a requirement, for example in kinetic studies, or in microarray analyses where microarray slides may need to be reanalysed over a period of days.

  揭示了一种对于标记和检测生物和其他材料有用的青霉素染料。该染料的化学式为（I）：其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13和R14中的至少一个是-L-M或-L-P，其中L是连接基团，M是目标键合基团，P是共轭组分，并且R3、R4、R5、R6、R7、R8、R9和R10中的至少一个包含氟。通过用氟取代并具有三个或更多磺酸基团的青霉素染料标记生物靶分子，得到的标记产品中减少了染料-染料聚集并提高了光稳定性，与没有这种取代的青霉素染料相比。本发明的染料在涉及荧光检测的分析中特别有用，其中需要连续或重复激发，例如在动力学研究中，或在微阵列分析中，微阵列玻片可能需要在数天内重新分析。
• Denitrogenative Pd/Cu‐catalyzed Suzuki‐type Cross‐coupling of Aryltrifluoroborates with Arylhydrazine Hydrochlorides in Water under Room Temperature
  作者：Guofang Wang、Mengting Meng、Liping Deng、Kai Cheng、Chenze Qi

  DOI：10.1002/aoc.4203

  日期：2018.3

  A water‐soluble palladium‐catalyzed Suzuki‐type cross‐coupling of aryltrifluoroborates with arylhydrazide hydrochlorides was efficiently developed under mild and environmentally benign conditions, in water without any ligand. The newly developed Pd/Cu co‐catalyzed denitrogenative reaction gave a range of structurally diverse substituted biaryls with good to excellent yields, in which the byproduct

  在温和，无害于环境的条件下，在没有任何配体的水中，水溶性钯催化的三氟硼酸芳基酯与芳酰肼盐酸盐的水溶性钯催化交叉偶联反应得到了有效开发。新开发的Pd / Cu共催化脱氮反应产生了一系列结构多样的取代联芳基，其收率良好至极佳，其中副产品为氮。
• Tridentate Complexes of Palladium(II) and Platinum(II) Bearing<i>bis</i>-Aryloxide Triazole Ligands: A Joint Experimental and Theoretical Investigation
  作者：Georges Dahm、Etienne Borré、Changkan Fu、Stéphane Bellemin-Laponnaz、Matteo Mauro

  DOI：10.1002/asia.201500600

  日期：2015.11

  novel class of palladium(II) and platinum(II) complexes bearing tridentate bis‐aryloxide triazole ligands was prepared by using straightforward and high‐yielding synthetic routes. The complexes were fully characterized and the molecular structures of four derivatives were unambigously determined by single‐crystal X‐ray diffractometric analyses. For the most promising luminescent PtII derivatives, further

  通过使用直接且高产的合成路线，制备了带有三齿双-芳氧基三唑配体的新型钯（II）和铂（II）配合物。通过单晶X射线衍射分析法明确表征了复合物，并明确确定了四种衍生物的分子结构。对于最有前途的发光Pt II衍生物，通过在不同条件下的电子吸收，稳态和时间分辨发射技术，进行了进一步的实验研究，以表征其光物理特征并确定发射激发态的性质。在脱气的流体溶液中的复合物显示宽且无特征的光致发光与λ EM= 522–585 nm，激发态寿命长达几微秒，量子产率（PLQY）高达17％，具体取决于辅助配体和三齿配体上取代基的性质。进行了使用密度泛函理论和时变DFT的计算研究，以深入了解负责光学跃迁和结构-光致发光关系的电子过程。实验和理论特性共同表明，辐射跃迁是由激发态产生的，该激发态具有混合的三重态歧管金属到配体的电荷转移和以配体为中心的（3 MLCT / 3 LC）特性。我们阐明了这种新的复合物家族在取代基变化时光物理性质的调节。
• Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates
  作者：Yange Huang、Pui Ying Choy、Junya Wang、Man-Kin Tse、Raymond Wai-Yin Sun、Albert Sun-Chi Chan、Fuk Yee Kwong

  DOI：10.1021/acs.joc.0c01599

  日期：2020.11.20

  A palladium-catalyzed C–N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical N,N-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)2 associated with newly developed phosphine ligand L1, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional

  已开发了钯催化的芳基肼与芳基甲苯磺酸酯之间的C–N键偶联反应，可轻松合成不对称的N，N-二芳基肼。利用与新开发的膦配体L1关联的Pd（TFA）2催化剂体系，芳基肼的单芳基化反应顺利进行，以良好的产率（高达95％）提供了具有良好官能团相容性的所需产品。该方法提供了从简单且容易获得的偶联组分中获得结构多样的N，N-二芳基肼的替代合成途径。
• [EN] INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS<br/>[FR] INHIBITEURS DE MYCOBACTERIUM TUBERCULOSIS RÉSISTANT AUX MÉDICAMENTS
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2015164482A1

  公开（公告）日：2015-10-29

  The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

  本发明提供了用于治疗结核病的新型吲哚酰胺化合物，包括用于治疗耐药性M-结核病的药物，含有吲哚酰胺的组合物以及使用吲哚酰胺与其他生物活性剂联合治疗需求的受试者的结核病的方法。