1-phenyl-1-(3-chlorophenylamino)-3-pentanone | 137351-27-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-phenyl-1-(3-chlorophenylamino)-3-pentanone
• CAS: 137351-27-0
• 化学式: C₁₇H₁₈ClNO
• 分子量: 287.789
• InChiKey: JHLNVHUULBAJHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-phenyl-1-(3-chlorophenylamino)-3-pentanone 在 间氯过氧苯甲酸 作用下， 以 苯 为溶剂， 生成
  参考文献：
  名称：

  Radical transformations of some N-alkylanilines by their oxidation with different agents: an EPR study

  摘要：

  N-Alkylanilines X-NH-Ph (Ph = substituted phenyl ring) with two different types of alkyl substituent X [X = C2H5-CO-CH2CH(Ph), X = CH3, C2H5, CH(CH3)(2), CH2C6H5] were oxidized using different agents. While oxidation with 3-chloroperbenzoic acid leads to production of the corresponding aminoxyl radicals X-NOaEuro cent-Ph, it was confirmed that application of PbO2 resulted in the formation of aminyl radicals X-N-aEuro cent-Ph, as indirectly proved by the spin-trapping method. Contrary to those transformations, with employment of either Pb(OAc)(4) or t-BuO (2) (aEuro cent) radical, reactions taking place on the alkyl substituent were also observed.

  DOI：

  10.1007/s00706-012-0874-6
• 作为产物：
  描述：

  苯甲醛 、 3-氯苯胺 、 丁酮 在 盐酸 作用下， 以 乙醇 为溶剂， 以90%的产率得到1-phenyl-1-(3-chlorophenylamino)-3-pentanone
  参考文献：
  名称：

  丁酮、芳香醛和芳香胺的曼尼希反应

  摘要：

  摘要 在少量浓盐酸的催化下，丁酮、芳香醛和芳香胺的曼尼希反应可在0～20℃直接进行。以高产率制备了十二种相应的曼尼希碱 (1)，即 1-芳基-1-芳基氨基-3-戊酮。

  DOI：

  10.1080/00397919108019818

文献信息

• Radical transformations of some N-alkylanilines by their oxidation with different agents: an EPR study
  作者：Lenka Šafaříková、Ladislav Omelka、Petr Majzlík、Jan Světlík

  DOI：10.1007/s00706-012-0874-6

  日期：2013.2

  N-Alkylanilines X-NH-Ph (Ph = substituted phenyl ring) with two different types of alkyl substituent X [X = C2H5-CO-CH2CH(Ph), X = CH3, C2H5, CH(CH3)(2), CH2C6H5] were oxidized using different agents. While oxidation with 3-chloroperbenzoic acid leads to production of the corresponding aminoxyl radicals X-NOaEuro cent-Ph, it was confirmed that application of PbO2 resulted in the formation of aminyl radicals X-N-aEuro cent-Ph, as indirectly proved by the spin-trapping method. Contrary to those transformations, with employment of either Pb(OAc)(4) or t-BuO (2) (aEuro cent) radical, reactions taking place on the alkyl substituent were also observed.
• The Mannich Reaction of Butanone, Aromatic Aldehydes and Aromatic Amines
  作者：Yi Lin、Zou Junhua、Lei Huangshu、He Qilin

  DOI：10.1080/00397919108019818

  日期：1991.10

  Abstract Under the catalysis of small amount of concentrated hydrochloric acid, the Mannich reaction of butanone, aromatic aldehydes and aromatic amines can be carried out directly at 0–20°C. Twelve corresponding Mannich bases (1), 1-aryl-1-arylamino-3-pentanones, were prepared in high yields.

  摘要 在少量浓盐酸的催化下，丁酮、芳香醛和芳香胺的曼尼希反应可在0～20℃直接进行。以高产率制备了十二种相应的曼尼希碱 (1)，即 1-芳基-1-芳基氨基-3-戊酮。