N-(2-bromo-2-(4-nitrophenyl)ethyl)-N,4-dimethylbenzenesulfonamide | 1214892-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-bromo-2-(4-nitrophenyl)ethyl)-N,4-dimethylbenzenesulfonamide
• 英文别名: N-[2-bromo-2-(4-nitrophenyl)ethyl]-N,4-dimethylbenzenesulfonamide
• CAS: 1214892-78-0
• 化学式: C₁₆H₁₇BrN₂O₄S
• 分子量: 413.292
• InChiKey: QUSOTAUDTNWEAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-硝基苯乙烯 、 N-甲基对甲苯磺酰胺 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以93%的产率得到N-(2-bromo-2-(4-nitrophenyl)ethyl)-N,4-dimethylbenzenesulfonamide
  参考文献：
  名称：

  Catalyst-free aminobromination of alkenes with N-methyl-p-toluenesulfonamide as nitrogen resource

  摘要：

  A catalyst-free electrophilic aminobromination system was described with N-methyl-p-toluenesulfon-amide (p-TsNHCH3) and N-bromosuccinimide (NBS) as nitrogen and bromine resources. The reaction can give vicinal haloamines in good yields, excellent regioselectivities, and stereoselectivities under convenient and mild condition. The existence of N-methyl group in the nitrogen resource was found to play an important role in the formation of vicinal haloamine product. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.059

文献信息

• Catalyst-free aminobromination of alkenes with N-methyl-p-toluenesulfonamide as nitrogen resource
  作者：Guangqian Zhang、Guanghui An、Jun Zheng、Yi Pan、Guigen Li

  DOI：10.1016/j.tetlet.2009.12.059

  日期：2010.2

  A catalyst-free electrophilic aminobromination system was described with N-methyl-p-toluenesulfon-amide (p-TsNHCH3) and N-bromosuccinimide (NBS) as nitrogen and bromine resources. The reaction can give vicinal haloamines in good yields, excellent regioselectivities, and stereoselectivities under convenient and mild condition. The existence of N-methyl group in the nitrogen resource was found to play an important role in the formation of vicinal haloamine product. (C) 2009 Elsevier Ltd. All rights reserved.