5-chloro-N-[(2-methoxyphenyl)methyl]-1,6-naphthyridine-2-carboxamide | 291757-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-chloro-N-[(2-methoxyphenyl)methyl]-1,6-naphthyridine-2-carboxamide
• CAS: 291757-44-3
• 化学式: C₁₇H₁₄ClN₃O₂
• 分子量: 327.77
• InChiKey: ZVRQGMZXJVTVIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-chloro-N-[(2-methoxyphenyl)methyl]-1,6-naphthyridine-2-carboxamide 在 potassium fluoride 作用下， 以 四氢呋喃 、 环丁砜 为溶剂， 生成 5-Methoxy-[1,6]naphthyridine-2-carboxylic acid 2-methoxy-benzylamide
  参考文献：
  名称：

  Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

  摘要：

  Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00265-1
• 作为产物：
  描述：

  N-(2-methoxybenzyl)-2-(1,6)naphthyridinecarboxamide 在 间氯过氧苯甲酸 、 三氯氧磷 作用下， 生成 5-chloro-N-[(2-methoxyphenyl)methyl]-1,6-naphthyridine-2-carboxamide
  参考文献：
  名称：

  Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

  摘要：

  Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00265-1

文献信息

• Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors
  作者：Laval Chan、Tomislav Stefanac、Nathalie Turcotte、Zhuhan Hu、Yanmin Chen、Jean Bédard、Suzanne May、Haolun Jin

  DOI：10.1016/s0960-894x(00)00265-1

  日期：2000.7

  Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.