2-chloro-N-[6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridin-3-yl]acetamide | 1116016-19-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-chloro-N-[6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridin-3-yl]acetamide
• 英文别名: 2-chloro-N-[6-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pyridin-3-yl]acetamide
• CAS: 1116016-19-3
• 化学式: C₁₀H₆ClF₃N₄O₂
• 分子量: 306.631
• InChiKey: VYWCIOAMRINSAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  80.9
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-chloro-N-(6-(N'-hydroxycarbamimidoyl)pyridin-3-yl)acetamide 、 三氟乙酸酐 在 氨 作用下， 以 水 为溶剂， 反应 2.0h， 以80%的产率得到2-chloro-N-[6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridin-3-yl]acetamide
  参考文献：
  名称：

  [EN] PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE
  [FR] DÉRIVÉS DE PYRIDYLE, LEUR PRÉPARATION ET UTILISATION.

  摘要：

  本发明涉及能够抑制磷脂酰肌醇-3-激酶（PI3k）、哺乳动物雷帕霉素靶蛋白（mTOR）和/或缺氧诱导因子1α（HIF-1α）介导信号的吡啶基衍生物。还公开了制备吡啶基衍生物的方法，以及它们在制造用于治疗由PI3K、mTOR和HIF-1α途径中的一个或多个信号通路失调引起的临床病症的药物组合物中的用途。吡啶基衍生物还可用于治疗由TNF-α介导的疾病或紊乱。

  公开号：

  WO2009019656A1

文献信息

• [EN] SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI<br/>[FR] OXADIAZOLES SUBSTITUÉS POUR LUTTER CONTRE DES CHAMPIGNONS PHYTOPATHOGÈNES
  申请人：BASF SE

  公开号：WO2017081310A1

  公开（公告）日：2017-05-18

  The present invention relates to novel oxadiazoles of the formula (I), or the N-oxides and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, or to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula (I), or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of the formula (I) and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of the formula I and to agrochemical compositions further comprising seeds.

  本发明涉及公式（I）的新型噁二唑，或其N-氧化物和/或其农业上有用的盐，以及它们用于控制植物病原真菌或对抗植物病原真菌的方法，该方法包括使用公式（I）中至少一种化合物、N-氧化物或其农业上可接受的盐的有效量处理真菌或要保护免受真菌攻击的材料、植物、土壤或种子；本发明还涉及混合物，包括至少一种公式（I）的化合物和至少一种来自除草剂、安全剂、杀菌剂、杀虫剂和植物生长调节剂组的其他杀虫活性物质；以及包括至少一种公式（I）的农药组合物和进一步包括种子的农药组合物。
• PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE
  申请人：Kumar Sanjay

  公开号：US20110077252A1

  公开（公告）日：2011-03-31

  The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1α pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-α.

  本发明涉及能够抑制磷脂酰肌醇-3-激酶（PI3k）、哺乳动物雷帕霉素靶蛋白（mTOR）和/或缺氧诱导因子1α（HIF-1α）介导信号的吡啶衍生物。还披露了制备吡啶衍生物的过程，并将其用于制造用于治疗由PI3K、mTOR和HIF-1α途径中一个或多个信号通路失调引起的临床情况的制药组合物。吡啶衍生物还可用于治疗由TNF-α介导的疾病或紊乱。
• Pyridyl derivatives, their preparation and use
  申请人：Piramal Enterprises Limited

  公开号：US08314103B2

  公开（公告）日：2012-11-20

  The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1α pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-α.

  本发明涉及一种能够抑制磷脂酰肌醇-3-激酶（PI3K）、哺乳动物雷帕霉素靶蛋白（mTOR）和/或缺氧诱导因子1α（HIF-1α）介导信号的吡啶基衍生物。还公开了制备吡啶基衍生物的过程，以及它们在制造用于治疗由PI3K、mTOR和HIF-1α途径中一个或多个信号通路失调引起的临床病症的药物组合物方面的用途。吡啶基衍生物还可用于治疗由TNF-α介导的病症或紊乱。
• SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
  申请人：BASF SE

  公开号：EP3373732A1

  公开（公告）日：2018-09-19
• US8314103B2
  申请人：——

  公开号：US8314103B2

  公开（公告）日：2012-11-20