(7-Methoxy-2,3-dihydro-1,4-benzodioxin-2-YL)methanamine | 2165-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: (7-Methoxy-2,3-dihydro-1,4-benzodioxin-2-YL)methanamine
• 英文别名: (6-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl)methanamine
• CAS: 2165-38-0
• 化学式: C₁₀H₁₃NO₃
• mdl: MFCD10697677
• 分子量: 195.21
• InChiKey: YOCXUUHCLNXZIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (7-Methoxy-2,3-dihydro-1,4-benzodioxin-2-YL)methanamine 、 7-(3-bromopropoxy)quinoline 、 N,N-二异丙基乙胺 在 氮气 、 碳酸氢钠 、 氯化钠 、 Sodium sulfate-III 、 silica gel 、 乙醇 、 盐酸 、 dichlorine monoxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以to give 1.5 g of the title compound as a yellow solid dihydrochloride monohydrate, m.p. 135°-142° C.的产率得到N-[3-(quinolin-7-yloxy)propyl]-2,3-dihydro-7-methoxy-1,4-benzodioxin-2-methanamine
  参考文献：
  名称：

  Antipsychotic quinoline derivatives of benzodioxanmethylamine

  摘要：

  该化合物的化学式为：##STR1## 其中R.sup.1和R.sup.2分别为氢，烷基，烷氧基，芳基烷氧基，脂肪酰氧基，羟基，卤素，氨基，单烷基或二烷基氨基，脂肪酰胺基或磺酰胺基，或R.sup.1和R.sup.2在一起为亚甲二氧基，乙二氧基或丙二氧基; R.sup.3为氢或烷基; n为整数2、3或4; 或其药学上可接受的盐，均为抗精神病药物。

  公开号：

  US05235055A1

文献信息

• Antipsychotic benzodioxan derivatives
  申请人：American Home Products Corporation

  公开号：US05166367A1

  公开（公告）日：1992-11-24

  A compound of the formula: ##STR1## wherein the dotted line represents optional unsaturation; R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, alkanamido or sulfonamido or R.sup.1 and R.sup.2 together are methylenedioxy, ethylenedioxy or propylenedioxy; R.sup.3 is hydrogen or alkyl; n is one of the integers 2,3 or 4; X is O or NR.sup.4, in which R.sup.4 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, are antipsychotic agents.

  公式为：##STR1## 其中虚线表示可选的不饱和度；R.sup.1和R.sup.2分别为氢、烷基、烷氧基、芳基烷氧基、烷酰氧基、羟基、卤素、氨基、单烷基或双烷基氨基、烷基酰胺或磺酰胺或R.sup.1和R.sup.2一起为亚甲二氧基、乙二氧基或丙二氧基；R.sup.3为氢或烷基；n为2、3或4中的一个整数；X为O或NR.sup.4，其中R.sup.4为氢或烷基；或其药学上可接受的盐，是抗精神病药物。
• ANTIPSYCHOTIC QUINOLINE DERIVATIVES OF BENZODIOXANMETHYLAMINE
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0658160A1

  公开（公告）日：1995-06-21
• Combination of a dopamine D2-receptor agonist and tiotropium or a derivative therof for treating obstructive airways and other inflammatory diseases
  申请人：Yeadon Michael

  公开号：US20070117788A1

  公开（公告）日：2007-05-24

  The present invention relates to a combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (I) a dopamine D2-receptor agonist that is therapeutically effective in the treatment of said diseases when administered by inhalation; together with (II) an anti-cholinergic agent consisting of a member selected from the group consisting of tiotropium and derivatives thereof that is therapeutically effective in the treatment of said diseases when administered by inhalation; as well as to a method of treating said obstructive airways and other inflammatory diseases comprising administering to said mammal by inhalation a therapeutically effective amount of said combination of therapeutic agents; and a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with said combination of therapeutic agents; and a package containing a pharmaceutical composition for insertion into a device capable of simultaneous or sequential delivery of said pharmaceutical composition in the form of an aerosol or dry powder dispersion to said mammal, where said device is a metered dose inhaler or a dry powder inhaler. It is preferred that said dopamine D2-receptor agonist component be bromocriptine mesylate, naxagolide hydrochloride, cabergoline, pergolide mesylate, quinpirole hydrochloride, or ropinirole hydrochloride; and that said anti-cholinergic agent component be tiotropium bromide.
• US4206125A
  申请人：——

  公开号：US4206125A

  公开（公告）日：1980-06-03
• US5126366A
  申请人：——

  公开号：US5126366A

  公开（公告）日：1992-06-30