(1E)-N-hydroxy-4-nitrobenzenecarboximidoyl chloride | 105782-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1E)-N-hydroxy-4-nitrobenzenecarboximidoyl chloride
• CAS: 105782-54-5
• 化学式: C₇H₅ClN₂O₃
• 分子量: 200.581
• InChiKey: PIQHICJFBSZFMS-VQHVLOKHSA-N

物化性质

• 沸点：
  376.6±44.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1E)-N-hydroxy-4-nitrobenzenecarboximidoyl chloride 、 1,3-二氯苯乙炔 在 三乙胺 作用下， 生成 5-(2,6-Dichlorophenyl)-3-(4-nitrophenyl)isoxazole
  参考文献：
  名称：

  Heterocyclic compounds useful to treat HCV

  摘要：

  本发明涉及替代二苯杂环化合物及其制药组合物，可抑制HCV病毒的复制。本发明还涉及使用该化合物和/或组合物来抑制HCV的复制和/或增殖，并用于治疗或预防HCV感染。

  公开号：

  US20040142985A1

文献信息

• 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis
  作者：Lalgudi S. Harikrishnan、Muthoni G. Kamau、Timothy F. Herpin、George C. Morton、Yalei Liu、Christopher B. Cooper、Mark E. Salvati、Jennifer X. Qiao、Tammy C. Wang、Leonard P. Adam、David S. Taylor、Alice Ye A. Chen、Xiaohong Yin、Ramakrishna Seethala、Tara L. Peterson、David S. Nirschl、Arthur V. Miller、Carolyn A. Weigelt、Kingsley K. Appiah、Jonathan C. O’Connell、R. Michael Lawrence

  DOI：10.1016/j.bmcl.2008.03.030

  日期：2008.4

  2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.

  从CETP抑制剂的基于荧光的高通量筛选中，鉴定出2-芳基苯并恶唑5为命中物。描述了利用A环和B环的阵列合成进行的合成和SAR研究。
• Novel Microwave-Assisted One-Pot Synthesis of Isoxazoles by a Three-Component Coupling-Cycloaddition Sequence
  作者：Thomas Müller、Benjamin Willy、Frank Rominger

  DOI：10.1055/s-2007-1000856

  日期：2008.1

  The consecutive Sonogashira coupling of acid chlorides with terminal alkynes, followed by 1,3-dipolar cycloaddition under dielectric heating of in situ generated nitrile oxides from hydroximinoyl chlorides furnishes isoxazoles in moderate to good yields in the sense of a one-pot three-component reaction.

  在介电加热条件下，通过羟胺酰氯现场生成的腈氧化物与末端炔烃进行连续的Sonogashira偶联，随后进行1,3-偶极环加成反应，以中等到良好的产率制备了异恶唑，实现了一种一锅法三组分反应。
• Regio- and stereoselective 1,3-dipolar cycloaddition of arylnitrile oxides to 5-acetoxy-2(5H)-furanone
  作者：Peter Oravec、Ľubor Fišera、Roman Gažo

  DOI：10.1007/bf00809361

  日期：1991.3

  Arylnitrile oxides undergo regio- and stereo-specific 1,3-dipolar cycloaddition reactions with 5-acetoxy-2(5H)-furanone. In each case a single product 3a-3g results from an anti approach to the 5-acetoxy substituent, the oxygen of the 1,3-dipole being attached to C-4 of furan. Under similar conditions 5-benzoyloxy-2(5H)-furanone yields 3h-3i. The structures of the adducts were determined by H-1 and C-13-NMR spectroscopy.
• Facile three-component domino reactions for the synthesis of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines
  作者：Pitchaimani Prasanna、Sundaravel Vivek Kumar、Pethaiah Gunasekaran、Subbu Perumal

  DOI：10.1016/j.tetlet.2013.04.126

  日期：2013.7

  The three-component domino reactions of pyridine/isoquinoline, phenacyl bromide, and substituted (E)-N-hydroxyarylimidoyl chloride in the presence of triethylamine afforded a series of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines. This one pot three-component transformation presumably proceeds via ylide generation/annulation/fragmentation/clehydration domino sequence of reactions. (C) 2013 Elsevier Ltd. All rights reserved.
• Heterocyclic compounds useful to treat HCV
  申请人：——

  公开号：US20040142985A1

  公开（公告）日：2004-07-22

  The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.

  本发明涉及替代二苯杂环化合物及其制药组合物，可抑制HCV病毒的复制。本发明还涉及使用该化合物和/或组合物来抑制HCV的复制和/或增殖，并用于治疗或预防HCV感染。