N,N'-diphthalimido oxallate | 17447-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N,N'-diphthalimido oxallate
• 英文别名: N,N'-oxalyldioxy-bis-phthalimide；diphthalimide N,N'-oxalate；diphthalimido oxalate；Bis-phthalimido-oxalat；Bis(1,3-dioxoisoindol-2-yl) oxalate
• CAS: 17447-57-3
• 化学式: C₁₈H₈N₂O₈
• 分子量: 380.27
• InChiKey: OVPATSAKYLCRGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N,N'-diphthalimido oxallate 、 N-苄氧羰基-L-苯丙氨酸 在 吡啶 作用下， 以 乙腈 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  A convenient synthesis of peptide using oxallates

  摘要：

  DOI：

  10.1016/s0040-4039(00)85923-7
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 草酰氯 在 三乙胺 作用下， 以 乙二醇二甲醚 为溶剂， 以42%的产率得到N,N'-diphthalimido oxallate
  参考文献：
  名称：

  Chemiluminescence

  摘要：

  本发明涉及一种新型的O-草酰羟胺组合物、反应以及利用这些组合物直接从化学能源产生光的方法。在此所指的“光”是指波长在大约350纳米到800纳米之间的电磁辐射。公开的化合物包括二邻苯二甲酰亚胺草酸酯、二琥珀亚胺草酸酯和二马来酰亚胺草酸酯。

  公开号：

  US03978079A1

文献信息

• New beta-amino-alpha-hydroxycarboxylic acids and their use
  申请人：Sankyo Company Limited

  公开号：EP0498680A1

  公开（公告）日：1992-08-12

  The compounds of the invention are β-amino-α-hydroxycarboxylic acid derivatives having the formula (I): wherein: R¹ represents a group of formula R(Z)xA-    wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula -NRaRb wherein Ra and Rb are hydrogen atoms, alkyl groups, unsubstituted or substituted cycloalkyl, heterocyclic, aralkenyl or aryl groups,    Z represents oxygen or sulphur;    A represents a group of formula -CO-, -COCO-, -SO-, -SO₂- or -CS-; and    x is the cipher 0 or the integer 1; R² represents a hydrogen atom, or a substituted or unsubstituted alkyl group; R³ is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; R⁴ is a hydrogen atom, a substituted or unsubstituted alkyl, aryl or heterocyclic group;    and R⁵ represents a group of formula -B-(CO)-Y-Rcy , wherein    B represents a heterocyclic group unsubstituted or substituted with at least one alkyl group;    Y represents an oxygen atom, a nitrogen atom or a sulphur atom;    y is the integer 1 when Y represents an oxygen atom or a sulphur atom, and 2 when Y represents a nitrogen atom; and    Rc represents       is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group;    and, where there are two groups or atoms represented by Rc, they are the same or different; and and pharmaceutically acceptable salts and esters thereof.

  本发明的化合物是β-氨基-α-羟基羧酸衍生物，具有以下式子（I）：其中：R¹表示以下式子的基团R（Z）xA-，其中R为氢，或取代或未取代的烷基，烯基，炔基，芳基或杂环基，或R为以下式子的基团-NRaRb，其中Ra和Rb为氢原子，烷基，未取代或取代的环烷基，杂环基，芳烯基或芳基；Z表示氧或硫；A表示以下式子的基团-CO-，-COCO-，-SO-，-SO₂-或-CS-；x为0或整数1；R²表示氢原子，或取代或未取代的烷基；R³为氢，或取代或未取代的烷基，烯基，炔基，芳基或杂环基；R⁴为氢原子，取代或未取代的烷基，芳基或杂环基；和R⁵表示以下式子的基团-B-（CO）-Y-Rcy，其中B表示未取代或取代的至少有一个烷基的杂环基；Y表示氧原子，氮原子或硫原子；当Y表示氧原子或硫原子时，y为整数1，当Y表示氮原子时，y为整数2；并且Rc表示氢原子，或取代或未取代的烷基，烯基，炔基，芳基或杂环基；当有两个由Rc表示的基团或原子时，它们是相同的或不同的；以及其药学上可接受的盐和酯。
• Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0587311A1

  公开（公告）日：1994-03-16

  Compounds of formula (I) : [wherein: R¹ is hydrogen, alkyl, aralkyl, -CORa, -CORb, -CSRa, -CSRb, -SO₂Rb, -CONHRb, -CSNHRb, -CONRbRb or -CSNRbRb; R² is hydrogen or alkyl; R³ is hydrogen, alkylidene, substituted alkyl, or Rb; R⁴ is optionally substituted alkyl, cycloalkyl, or aryl; R⁵ is RbO-, RbRbN-, RbHN-, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R⁵ is -(CH₂)p-D-(CH₂)r- [where D is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and p and r are each 0 or an integer from 1 to 5]; A is -(CH₂)m-B-(CH₂)n- [where B is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and m and n are each 0 or an integer from 1 to 5]; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl]; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.

  化合物的化学式为(I)：[其中：R¹为氢，烷基，芳基烷基，-CORa，-CORb，-CSRa，-CSRb，-SO₂Rb，-CONHRb，-CSNHRb，-CONRbRb或-CSNRbRb；R²为氢或烷基；R³为氢，烷基亚甲基，取代烷基或Rb；R⁴为可选取代的烷基，环烷基或芳基；R⁵为RbO-，RbRbN-，RbHN-，芳基烷氧羰氧基氧或芳基烷氧羰氨基，或R⁵为-(CH₂)p-D-(CH₂)r- [其中D为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；p和r分别为0或1到5的整数]；A为-(CH₂)m-B-(CH₂)n- [其中B为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；m和n分别为0或1到5的整数]；Ra为烷氧基，芳基烷氧基，芳氧基或烷氧羰基；Rb为可选取代的烷基，环烷基，杂环，芳基或芳基烷烯基]；以及其药学上可接受的盐和酯以及其前药，具有抑制HIV蛋白酶活性的能力，因此可用于治疗和预防艾滋病。
• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• Azoxy compounds
  申请人：KOWA COMPANY, LTD.

  公开号：EP0443513A2

  公开（公告）日：1991-08-28

  A compound expressed by the formula: in which R₁₁, R₂₁ and R₃₁ are identical with or different from each other and each denotes a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a haloalkyl group, an alkoxy group, an alkylthio group, an aryl or an aralkyl group which aromatic ring is optionally substituted appropriately by one to three substituents or a heterocyclic group optionally substituted appropriately by one to three substituents, or R₁₁ and R₂₁ may together form an alkylene group, Y denotes O or NOH, with a proviso that where R₂₁ (or R₁₁) and R₃₁ denote a hydrogen atom at the same time, R₁₁ (or R₂₁) cannot represent an n-butyl group. This compound is useful as an antifungal agent.

  由式表示的化合物： 其中R₁₁、R₂₁和R₃₁彼此相同或不同，且各自表示氢原子、卤素原子、烷基、烯基、卤代烷基、烷氧基、烷硫基、芳基或芳烷基（其芳香环可任选被一至三个取代基适当取代），或杂环基（可任选被一至三个取代基适当取代）、或 R₁₁ 和 R₂₁ 可共同形成一个亚烷基，Y 表示 O 或 NOH、但 R₂₁（或 R₁₁）和 R₃₁同时表示氢原子时，R₁₁（或 R₂₁）不能代表正丁基。该化合物可用作抗真菌剂。
• Chemiluminescent materials and method of making same
  申请人：The United States of America, as represented by the Secretary of the Air Force

  公开号：US10040993B1

  公开（公告）日：2018-08-07

  Chemiluminescent materials are provided that include an encapsulated oxalate-containing composition that includes a core portion and a polymeric coating, a peroxide source, and a fluorescent dye. The core portion includes an oxalate; a polymerizable component composition that polymerizes upon exposure to ultraviolet radiation; a photosensitizer; and an ultraviolet screening agent. The polymeric coating layer surrounding the core portion comprises a polymer derived from the polymerizable component composition. A fluorescent dye may be intermixed in the oxalate-containing composition, intermixed with the peroxide source, present in the chemiluminescent material as a separate dye layer or particle, or present within another component of the chemiluminescent material. A method for making the chemiluminescent material is also provided.

  所提供的化学发光材料包括一种封装的含草酸盐的组合物，该组合物包括核心部分和聚合物涂层、过氧化物源和荧光染料。核心部分包括草酸盐、在紫外线辐射下聚合的可聚合成分组合物、光敏剂和紫外线屏蔽剂。围绕核心部分的聚合物涂层包括从可聚合成分组合物中提取的聚合物。荧光染料可以混合在含草酸盐的组合物中，与过氧化物源混合，作为单独的染料层或颗粒存在于化学发光材料中，或存在于化学发光材料的另一种成分中。此外，还提供了一种制造化学发光材料的方法。