2-chloro-6-propylpyridine | 120145-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-6-propylpyridine
• 英文别名: 2-Chlor-6-propyl-pyridin
• CAS: 120145-21-3
• 化学式: C₈H₁₀ClN
• 分子量: 155.627
• InChiKey: FJAHQCQZDLYUFR-UHFFFAOYSA-N

物化性质

• 沸点：
  81.0-81.2 °C(Press: 6 Torr)
• 密度：
  1.073 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-6-propylpyridine 在 盐酸 、 palladium on activated charcoal 作用下， 生成 2-丙基吡啶
  参考文献：
  名称：

  Methyl n-Propyl Ketone and its Conversion to n-Propylpyridine

  摘要：

  DOI：

  10.1021/ja01147a523
• 作为产物：
  描述：

  2-hydroxy-6-propyl-nicotinic acid 在 五氯化磷 、 三氯氧磷 作用下， 生成 2-chloro-6-propylpyridine
  参考文献：
  名称：

  Methyl n-Propyl Ketone and its Conversion to n-Propylpyridine

  摘要：

  DOI：

  10.1021/ja01147a523

文献信息

• QUINOLINONE-PYRAZOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
  申请人：Beshore Douglas C.

  公开号：US20120196845A1

  公开（公告）日：2012-08-02

  The present invention is directed to quinolinone-pyrazolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

  本发明涉及公式（I）的喹啉酮-吡唑酮化合物，它们是M1受体正向变构调节剂，可用于治疗M1受体参与的疾病，如阿尔茨海默病、精神分裂症、疼痛或睡眠障碍。本发明还涉及包括上述化合物的制药组合物，以及在治疗M1受体介导的疾病中使用上述化合物和组合物的方法。
• PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：BARTBERGER Michael David

  公开号：US20110319378A1

  公开（公告）日：2011-12-29

  The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

  本发明提供了公式I的MDM2抑制剂化合物，其中变量如上所定义，这些化合物可用作治疗剂，特别是用于治疗癌症。本发明还涉及含有MDM2抑制剂的药物组合物。
• METAL COMPLEX, PYRIDYLPHOSPHINE COMPOUND, AND METHOD FOR PRODUCING ALKYL METHACRYLATE
  申请人：Kawamura Masato

  公开号：US20120214999A1

  公开（公告）日：2012-08-23

  A metal complex having a pyridylphosphine compound represented by the formula (1) and a Group 10 metal atom of the periodic table.

  一种具有式（1）所表示的吡啶膦化合物和周期表第10族金属原子的金属配合物。
• 6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents
  作者：Michael R. Pavia、Charles P. Taylor、Sandra J. Lobbestael

  DOI：10.1021/jm00126a015

  日期：1989.6

  The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.
• PAVIA, MICHAEL R.;TAYLOR, CHARLES P.;LOBBESTAEL, SANDRA J., J. MED. CHEM., 32,(1989) N, C. 1237-1242
  作者：PAVIA, MICHAEL R.、TAYLOR, CHARLES P.、LOBBESTAEL, SANDRA J.

  DOI：——

  日期：——