4-chloro-2,3-dinitro-benzoic acid amide | 101420-99-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-2,3-dinitro-benzoic acid amide
• 英文别名: 4-Chlor-2,3-dinitro-benzoesaeure-amid；4-Chloro-2,3-dinitrobenzamide
• CAS: 101420-99-9
• 化学式: C₇H₄ClN₃O₅
• 分子量: 245.579
• InChiKey: QCRNIRFHVMOBTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-chloro-2,3-dinitro-benzoic acid amide 、 乙酸乙酯 反应 3.0h， 以gave 2-(aziridin-1-yl)-4-chloro-3-nitrobenzamide (16) as a yellow powder, mp 216° C的产率得到2-(aziridin-1-yl)-4-chloro-3-nitrobenzamide
  参考文献：
  名称：

  Nitrophenylaziridine compounds and their use as prodrugs

  摘要：

  提供一系列的环氧乙烷基-1-基硝基苯酰胺作为前药，与硝基还原酶（NR）酶一起使用。酰胺可能具有1或2个取代基，这些取代基可能是笨重和极性的。例如，公式（A）的5-（环氧乙烷基-1-基）-N-[2-（4-吗啡基）乙基]-2,4-二硝基苯酰胺被发现对所有测试的NR+细胞系都具有高活性。

  公开号：

  US06517836B1
• 作为产物：
  描述：

  4-chloro-2,3-dinitrobenzoic acid 生成 4-chloro-2,3-dinitro-benzoic acid amide
  参考文献：
  名称：

  Progress and records in the study of endogenetic mineralization during collisional orogenesis

  摘要：

  To develop and perfect the theory of plate tectonics and regional metallogeny, metallogenesis during collisional orogenesis should be thoroughly studied and wilt attract increasing attention of more and more scientists. This paper presents the main aspects of research and discussions on metallogenesis during collisional orogenesis after the development of plate tectonics, and accordingly divides the study history into two stages, i.e. the junior stage during 1971-1990 and the senior stage after 1990. Beginning with the negation of mineralization in the collision regime by Guild (1971), the focus of study was put on whether there occurred any mineralization during collisional orogenesis at the junior stage. At the senior stage, which is initiated by the advance of metallogenic and petrogenic model for collisional orogenesis, scientists begin to pay their attention to the geodynamic mechanism of metallogenesis, spatial and temporal distribution of ore deposits, ore-forming fluidization, relationship between petrogenesis and mineralization in collisional orogenesis, etc, Abundance of typical collisional orogens such as Himalayan, China has best natural conditions to study collisional metallogenesis. Great progress in the study of metallogenesis during collisional orogenesis has been made by Chinese geologists. Therefore, we hope that the Chinese geologists and Chinese governments at various levels to pay more attention to the study of collisional metallogenesis. Some urgent problems are suggested to be solved so as to bring about breakthroughs in the aspects concerned.

  DOI：

  10.1007/bf02884893

文献信息

• NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS
  申请人：CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

  公开号：EP1109550A2

  公开（公告）日：2001-06-27
• US6517836B1
  申请人：——

  公开号：US6517836B1

  公开（公告）日：2003-02-11
• [EN] NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS<br/>[FR] NOUVEAUX COMPOSES DE NITROPHENYLAZIRIDINE ET LEUR EMPLOI COMME PRODROGUE
  申请人：CANCER RES CAMPAIGN TECH

  公开号：WO2000013683A2

  公开（公告）日：2000-03-16

  A range of aziridin-1-yl nitrobenzamides (A-C) are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2 N-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl) -N-[2-(4-morpholino) ethyl] -2,4-dinitrobenzamide of Compound (1) was found to be highly active against all NR+ cell lines tested.