3t-[2]furyl-acrylic acid-[2]pyridylamide | 91973-59-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3t-[2]furyl-acrylic acid-[2]pyridylamide
• 英文别名: 3t-[2]Furyl-acrylsaeure-[2]pyridylamid；3-Furan-2-yl-N-pyridin-2-yl-acrylamide；(E)-3-(furan-2-yl)-N-pyridin-2-ylprop-2-enamide
• CAS: 91973-59-0
• 化学式: C₁₂H₁₀N₂O₂
• 分子量: 214.224
• InChiKey: XOPHQUWQRVLDOP-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3t-[2]furyl-acrylic acid-[2]pyridylamide 、 2-溴苯乙酮 以 乙酸乙酯 为溶剂， 反应 3.0h， 生成 2-(3-(2-furyl)acryloyl)amino-1-(2-oxo-2-phenylethyl)pyridinium bromide
  参考文献：
  名称：

  N-Phenacylpyridinium Bromides as Acid Corrosion Inhibitors

  摘要：

  The inhibiting effect of N-phenacylpyridinium bromides with the amide group in the pyridine ring on corrosion of carbon steel in 3 M sulfuric acid is studied. A relationship between the nature of substituents at the amide group and the corrosion-protective properties of the compounds studied is revealed. Compounds demonstrating high protection efficiency in acid solutions at elevated temperatures are found.

  DOI：

  10.1023/b:rjac.0000044159.65275.47
• 作为产物：
  描述：

  3-(fur-2-yl)crotonic acid 在 氯化亚砜 、 三乙胺 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 3t-[2]furyl-acrylic acid-[2]pyridylamide
  参考文献：
  名称：

  N-Phenacylpyridinium Bromides as Acid Corrosion Inhibitors

  摘要：

  The inhibiting effect of N-phenacylpyridinium bromides with the amide group in the pyridine ring on corrosion of carbon steel in 3 M sulfuric acid is studied. A relationship between the nature of substituents at the amide group and the corrosion-protective properties of the compounds studied is revealed. Compounds demonstrating high protection efficiency in acid solutions at elevated temperatures are found.

  DOI：

  10.1023/b:rjac.0000044159.65275.47

文献信息

• Utilities of amide compounds
  申请人：——

  公开号：US20040235888A1

  公开（公告）日：2004-11-25

  Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): 1 in which ring A and Ar 1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y 1 and Y 2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.

  提供了一种具有增强apoAI表达活性的化合物，可用作药物。公开了式（I）的化合物：其中环A和Ar1分别是单环或双环芳香碳环族或芳香杂环族，每个都可以选择性地被取代，或类似物; R是氢或类似物; Z是氧或类似物; Y1和Y2是氢，较低的烷基或类似物; n是0到2的整数; 断线表示键的存在或不存在; 波浪线表示相对于双键的顺反式异构。
• Mndshojan, 1957, vol. 10, p. 143,145, 155
  作者：Mndshojan

  DOI：——

  日期：——
• New utilities of amide compounds
  申请人：Yamamori Teruo

  公开号：US20080221112A1

  公开（公告）日：2008-09-11

  Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar 1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y 1 and Y 2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
• US7429593B2
  申请人：——

  公开号：US7429593B2

  公开（公告）日：2008-09-30
• US8106051B2
  申请人：——

  公开号：US8106051B2

  公开（公告）日：2012-01-31