Flupirtine gluconate | 815586-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Flupirtine gluconate
• 英文别名: ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
• CAS: 815586-85-7
• 化学式: C21H29FN4O9
• 分子量: 500.5
• InChiKey: KTUKTXYTLNEYHO-IFWQJVLJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.51
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  228
• 氢给体数：
  9
• 氢受体数：
  13

文献信息

• Sulfonate salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine
  申请人：Hoock Christoph

  公开号：US20090318506A1

  公开（公告）日：2009-12-24

  Flupirtine acid addition salts having the following formula (2), wherein R represents a substituted or unsubstituted C 1 -C 12 -alkyl or a substituted or unsubstituted C 6 -C 10 -aryl group, have been prepared.

  制备了具有以下公式（2）的氟匹利酸盐，其中R代表取代或未取代的C1-C12烷基或取代或未取代的C6-C10芳基基团。
• [EN] SULFONATE SALTS OF FLUPIRTINE<br/>[FR] SELS SULFONATE DE FLUPIRTINE
  申请人：AWD PHARMA GMBH & CO KG

  公开号：WO2009152142A1

  公开（公告）日：2009-12-17

  Flupirtine acid addition salts having the following formula (2), wherein R represents a substituted or unsubstituted C1-C12-alkyl or a substituted or unsubstituted C6-C10-aryl group, have been prepared.

  已制备出具有以下式子（2）的氟匹利酸盐酸，其中R代表取代或未取代的C1-C12烷基或取代或未取代的C6-C10芳基基团。
• FLUPIRTINE SALTS AND POLYMORPHS
  申请人：KALOFONOS Isabel

  公开号：US20120028930A1

  公开（公告）日：2012-02-02

  The present invention includes salts and polymorphs of flupirtine including, but not limited to carboxylic acid salts and sulfonic acid salts and their polymorphs. The present invention also includes pharmaceutical compositions comprising the salts and polymorphs of flupirtine. The invention also relates to the therapeutic use of the flupirtine salts and polymorphs to treat nervous system disorders, pain disorders, musculoskeletal disorders, and other diseases and conditions.

  本发明包括氟哌利多的盐和多晶形式，包括但不限于羧酸盐和磺酸盐及其多晶形式。本发明还包括包含氟哌利多盐和多晶形式的药物组合物。本发明还涉及使用氟哌利多盐和多晶形式治疗神经系统疾病、疼痛疾病、肌肉骨骼疾病和其他疾病和病况的治疗用途。
• CARBOXYLIC ACID SALTS OF 2-AMINO-3-CARBETHOXYAMINO-6-(4-FLUORO-BENZYLAMINO)-PYRIDINE
  申请人：Hoock Christoph Martin

  公开号：US20090306150A1

  公开（公告）日：2009-12-10

  The preparation of flupirtine carboxylate acid addition salts having the following formula (2), wherein R represents hydrogen or a C 1 -C 6 alkyl group, with the proviso that RCOOH is neither maleic acid nor gluconic acid, is described.

  本文描述了制备以下式子（2）的氟匹利酸盐，其中R代表氢或C1-C6烷基，但RCOOH不是马来酸或葡萄糖酸。
• FLUPIRTINE HYDROCHLORIDE MALEIC ACID COCRYSTAL
  申请人：Kalofonos Isabel

  公开号：US20110275679A1

  公开（公告）日：2011-11-10

  The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.

  本发明涉及氟匹林的晶体形式，特别是1:1氟匹林盐酸盐马来酸共晶体。描述了制备和表征1:1氟匹林盐酸盐马来酸共晶体的方法。本发明还涉及使用氟匹林盐酸盐马来酸共晶体治疗神经系统疾病、疼痛性疾病和肌肉骨骼疾病以及含有共晶体的药物组合物。