di-n-hexylmethylphosphine | 3385-84-0

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: di-n-hexylmethylphosphine
• 英文别名: Methyl-dihexyl-phosphin；Dihexyl(methyl)phosphane
• CAS: 3385-84-0
• 化学式: C₁₃H₂₉P
• 分子量: 216.347
• InChiKey: GJZKQIFATBQWBJ-UHFFFAOYSA-N

物化性质

• 沸点：
  274.7±9.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  di-n-hexylmethylphosphine 在 双氧水 作用下， 生成 二己基(甲基)氧膦
  参考文献：
  名称：

  3d-Orbital Resonance in Trivalent Organophosphines. I. Metalation of Methylphosphines

  摘要：

  DOI：

  10.1021/jo01017a055
• 作为产物：
  描述：

  甲基二氯膦 、 溴己烷 在 magnesium 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以26%的产率得到di-n-hexylmethylphosphine
  参考文献：
  名称：

  使用基于多面体低聚倍半硅氧烷核心的含烷基膦树枝状聚合物的加氢羰基化反应

  摘要：

  通过LiCH 2 PR 2将HPR 2（R = Et，Cy）自由基加成到烯基上或在氯硅烷上进行亲核取代反应（R ＝ Me，Hex）用于制备基于多面体低聚倍半硅氧烷（POSS）核的第一代和第二代含烷基膦的树枝状聚合物。第一代树枝状聚合物（G1）建立在16或24个臂上，这些臂是氯化物，乙烯基或烯丙基部分。进行氢化硅烷化（氯硅烷），然后对八乙烯基官能化的POSS进行乙烯基化或烯丙基化，得到了这些G1树状大分子。依次进行氢化硅烷化/烯丙基化，然后进行氢化硅烷化/乙烯基化，产生了第二代树枝状聚合物（G2）的框架。含磷的树枝状大分子用作在极性溶剂（乙醇或THF）中烯烃（己-1-烯，辛-1-烯，壬-1-烯，丙-1-烯-2-醇）的烃基化的配体）配合物[Rh（acac）（CO）2 ]或[Rh 2（O 2CMe）4 ]作为金属源。对于二乙基膦树状大分子，获得的醇产物的直链与支链比率高达3：1。发现反应主要通过形成相应的醛来进行。

  DOI：

  10.1039/b200303a

文献信息

• ANTIMICROBIAL CATIONIC POLYCARBONATES
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20140301967A1

  公开（公告）日：2014-10-09

  Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

  具有一个或两个阳离子聚碳酸酯链的抗菌阳离子聚合物是通过有机催化的环氧开聚合制备的。其中一种抗菌阳离子聚合物具有基本由阳离子碳酸酯重复单元构成的聚合物链，与一个或两个末端基团相连。末端基团可以包括胆固醇等生物活性化合物的共价结合形式。其他抗菌阳离子聚合物具有随机共聚碳酸酯链，其中含有少量疏水重复单元，带有维生素E和/或维生素D2的共价结合形式。这些阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。
• METHOD FOR PRODUCING CATALYST FOR CYCLIC CARBONATE SYNTHESIS
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20160108071A1

  公开（公告）日：2016-04-21

  The present invention provides a method for easily and inexpensively producing a heterogeneous catalyst used to synthesize a cyclic carbonate by reacting an epoxide with carbon dioxide and having excellent catalyst activity; a catalyst obtained using said manufacturing method; and a method for synthesizing a cyclic carbonate using said catalyst. A method for producing a catalyst that is used for the purpose of synthesizing a cyclic carbonate by subjecting to a reaction an epoxide with carbon dioxide, said method comprising the following steps (a) and (b): (a) a step of obtaining a catalyst precursor having a haloalkyl group or a haloaryl group by reacting a silane compound with a silica gel in the presence of xylene, the silane compound having a haloalkyl group or a haloaryl group and (b) a step of obtaining a catalyst for synthesizing a cyclic carbonate by reacting the catalyst precursor obtained in step (a) with a tertiary phosphine.

  本发明提供了一种用于通过将环氧化合物与二氧化碳反应来合成环状碳酸酯的异质催化剂的简便且廉价的生产方法；采用所述制备方法获得的催化剂；以及使用该催化剂合成环状碳酸酯的方法。用于生产一种用于合成环状碳酸酯的催化剂的方法，通过将环氧化合物与二氧化碳反应，该方法包括以下步骤(a)和(b)：(a)通过在二甲苯存在下将硅烷化合物与二氧化硅反应以获得具有卤代烷基或卤代芳基的催化剂前驱体的步骤，其中所述硅烷化合物具有卤代烷基或卤代芳基；以及(b)通过将步骤(a)中获得的催化剂前驱体与三膦反应以获得用于合成环状碳酸酯的催化剂的步骤。
• VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20180117162A1

  公开（公告）日：2018-05-03

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).

  制备了包含以下组成部分的凝胶形成嵌段共聚物：i）主要由二价聚乙二醇链组成的中心亲水性块和ii）通过带有一个或多个氢键形成*—N(H)—*基团连接到中心块的两个外周单碳酸酯或多碳酸酯疏水性块。疏水性块包含一个或多个含维生素的亚单位。这些凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。水凝胶组合物在药物输送的库存注射中具有实用性。与由聚乙二醇制备的类似水凝胶相比，氢键*—N(H)—*基团提供了凝胶在体内降解之前更长的生命周期，以及与水凝胶相比更延长和控制释放速率的疏水性药物。
• ORGANOMETALLIC COMPOUND, CATALYST FOR POLYMERIZATION OF POLAR GROUP-CONTAINING NORBORNENE AND PROCESS FOR PRODUCING NORBORNENE POLYMER
  申请人：Watanabe Saisuke

  公开号：US20090247729A1

  公开（公告）日：2009-10-01

  An organometallic compound obtained by mixing following (a), (b) and (c): (a) a neutral organopalladium complex that has a palladium atom and two organic ligands each having at least three carbon atoms participating in a bond to the palladium atom; (b) an organophosphorus compound having one phosphorus atom; and (c) a salt comprising: an anion having no unshared electron pair in a central atom; and a counter-cation. And a process for producing a norbornene compound polymer, the process comprising: subjecting at least one norbornene compound represented by formula (A) as defined in the specification to polymerization reaction in a presence of an organometallic complex catalyst produced by mixing compound (a) and compound (d) described in the specification.

  一种有机金属化合物，通过混合以下物质（a）、（b）和（c）获得：（a）一种中性有机钯配合物，其具有钯原子和两个有机配体，每个配体至少有三个碳原子参与与钯原子的键合；（b）一种含有一个磷原子的有机磷化合物；和（c）一种盐，包括：一个中心原子中没有未共享电子对的阴离子；和一个对离子。以及一种生产诺博尔烯化合物聚合物的方法，该方法包括：在混合化合物（a）和规范中描述的化合物（d）的有机金属配合物催化剂的存在下，将至少一种由式（A）表示的诺博尔烯化合物进行聚合反应。
• PROCESS FOR PRODUCING CARBONYL COMPOUNDS BY DEHYDROGENATION OF ALCOHOLS
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP1160245A1

  公开（公告）日：2001-12-05

  The present invention provides a method for producing a carbonyl compound by dehydrogenating an alcohol. Namely, it relates to a method for producing a carbonyl compound, which comprises dehydrogenating an alcohol in the presence of a complex compound catalyst comprising ruthenium and an organic phosphine wherein aliphatic carbons are bonded to two or more of the three bonding hands of the phosphorus atom.

  本发明提供了一种通过脱氢醇生产羰基化合物的方法。也就是说，本发明涉及一种生产羰基化合物的方法，该方法包括在由钌和有机膦组成的复合催化剂存在下对醇进行脱氢，其中脂肪族碳与磷原子三个键手中的两个或两个以上键手成键。