N-(4-hydroxyphenyl)-2-naphthalen-2-ylsulfanylacetamide | 1110920-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4-hydroxyphenyl)-2-naphthalen-2-ylsulfanylacetamide
• CAS: 1110920-99-4
• 化学式: C₁₈H₁₅NO₂S
• 分子量: 309.389
• InChiKey: DKAVYQCDGCUFLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-hydroxyphenyl)-2-naphthalen-2-ylsulfanylacetamide 、 2-溴丙酸乙酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以80%的产率得到Ethyl 2-[4-[(2-naphthalen-2-ylsulfanylacetyl)amino]phenoxy]propanoate
  参考文献：
  名称：

  Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

  摘要：

  A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.040
• 作为产物：
  描述：

  2-萘硫醇 在 氯化亚砜 、 potassium carbonate 、 potassium hydroxide 作用下， 以 甲醇 、 水 、 丙酮 、 苯 为溶剂， 反应 7.0h， 生成 N-(4-hydroxyphenyl)-2-naphthalen-2-ylsulfanylacetamide
  参考文献：
  名称：

  Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

  摘要：

  A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.040

文献信息

• Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
  作者：Koneni V. Sashidhara、Gopala Reddy Palnati、Ranga Prasad Dodda、Ravi Sonkar、A.K. Khanna、Gitika Bhatia

  DOI：10.1016/j.ejmech.2012.09.040

  日期：2012.11

  A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia. (C) 2012 Elsevier Masson SAS. All rights reserved.