diethyl-(4-methyl-thiazol-2-yl)-amine | 164397-12-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: diethyl-(4-methyl-thiazol-2-yl)-amine
• 英文别名: Diaethyl-(4-methyl-thiazol-2-yl)-amin；N,N-diethyl-4-methyl-1,3-thiazol-2-amine
• CAS: 164397-12-0
• 化学式: C₈H₁₄N₂S
• mdl: MFCD06360139
• 分子量: 170.279
• InChiKey: XILGXBZRDDESBW-UHFFFAOYSA-N

物化性质

• 沸点：
  233.8±33.0 °C(Predicted)
• 密度：
  1.068±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diethyl-(4-methyl-thiazol-2-yl)-amine 在 硫酸 、 三氧化硫 作用下， 生成 4-methyl-2-oxo-2,3-dihydro-thiazole-5-sulfonic acid
  参考文献：
  名称：

  Synthesis of chlorin e6 amide derivatives

  摘要：

  The reactions of methylpheophorbide a with primary and secondary amines have been investigated as a means for the synthesis of sensitizers used in the photodynamic therapy of tumors.

  DOI：

  10.1070/mc2002v012n02abeh001536
• 作为产物：
  描述：

  N,N-二乙基-硫脲 、 一氯丙酮 在 水 作用下， 生成 diethyl-(4-methyl-thiazol-2-yl)-amine
  参考文献：
  名称：

  4'：5'-二氢乙二醛（2'：1'- 2：2：3）噻唑鎓盐和噻唑衍生物的紫外线吸收

  摘要：

  DOI：

  10.1039/jr9550002943

文献信息

• REAGENT FOR ORGANIC SYNTHESIS REACTION CONTAINING ORGANIC TRIOL BORATE SALT
  申请人：Miyaura Norio

  公开号：US20100087646A1

  公开（公告）日：2010-04-08

  [Problem] To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. [Means for Solving Problems] The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

  [问题] 提供一种含有有机硼化合物的试剂，用于有机合成反应，该试剂不会发生脱水三聚体化，无需碱激活，稳定且活性高。 [解决问题的方法] 用于有机合成反应的试剂包含由通式(I)至(III)和通式(XVI)中的任一表示的有机三醇硼酸盐，其中R1代表烷基、烯基等；R2代表可选择取代的烷基、烯基、炔基等，或代表氢；m+代表碱金属离子、磷酰离子或给定的铵离子；M2+代表碱土金属；X代表卤素或烷氧基；Y代表碱金属离子等；A代表可选择取代的亚甲基；n代表整数。
• COMBINATION OF KINASE INHIBITORS AND USES THEREOF
  申请人：INTELLIKINE, LLC

  公开号：US20150030588A1

  公开（公告）日：2015-01-29

  The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.

  本发明提供了一种治疗与PI3-激酶a和/或受体酪氨酸激酶（RTK）有关的疾病状况的方法。另一方面，该发明提供了一种治疗与PI3-激酶α和/或受体酪氨酸激酶（RTK）有关的疾病状况的方法。另一方面，提出了一种抑制细胞中Akt（S473）磷酸化的方法。
• [EN] HETEROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2015051244A1

  公开（公告）日：2015-04-09

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及与激酶活性相关的疾病和病况的化合物、药物组合物和治疗方法在此进行描述。
• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Ren Pingda

  公开号：US20120122838A1

  公开（公告）日：2012-05-17

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及与激酶活性相关的疾病和病况的化合物、药物组合物和治疗方法在此进行描述。
• CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
  申请人：Ren Pingda

  公开号：US20090312319A1

  公开（公告）日：2009-12-17

  Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

  本文描述了调节PI3激酶活性的化学实体、含有这些化学实体的药物组合物，以及使用这些化学实体治疗与PI3激酶活性相关的疾病和病症的方法。