3-Oxo-3-(pyrrolidin-1-yl)propanal | 63442-59-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-Oxo-3-(pyrrolidin-1-yl)propanal
• 英文别名: 3-oxo-3-pyrrolidin-1-ylpropanal
• CAS: 63442-59-1
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: ONIWVBXSRXIGLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS<br/>[FR] 3-AMINOPYRAZOLES TRICYCLIQUES N-SUBSTITUES COMME INHIBITEURS DES RECEPTEURS DU PDFG
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2003097609A1

  公开（公告）日：2003-11-27

  The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the presentinvention and to methods for treating conditions such as tumors and other cell proliferative disorders.

  本发明涉及N-取代的三环3-氨基吡唑衍生物，其作为血小板源性生长因子受体（PDGF-R）激酶的抑制剂具有用途，以及制备该衍生物的方法。本发明还涉及包含本发明化合物的制药组合物，以及用于治疗肿瘤和其他细胞增殖性疾病的方法。
• N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
  申请人：——

  公开号：US20040082639A1

  公开（公告）日：2004-04-29

  The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.

  该发明涉及N-取代的三环3-氨基吡唑衍生物，它们可用作血小板源性生长因子受体（PDGF-R）激酶的抑制剂，以及制备该衍生物的方法。本发明还涉及包含本发明化合物的药物组合物，以及治疗肿瘤和其他细胞增殖性疾病的方法。
• PYRAZOLE COMPOUNDS
  申请人：Shia Kak-shan

  公开号：US20090042864A2

  公开（公告）日：2009-02-12

  This invention relates to pyrazole compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.

  本发明涉及以下公式（I）所示的吡唑化合物：公式（I）中的每个变量在说明书中有定义。这些化合物可用于治疗大麻素受体介导的疾病。
• N-substituted tricyclic 1-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
  申请人：Ho Yung Chih

  公开号：US20070142305A1

  公开（公告）日：2007-06-21

  The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell. proliferative disorders.

  本发明涉及N-取代的三环3-氨基吡唑衍生物，其可用作血小板源性生长因子受体（PDGF-R）激酶的抑制剂，以及制备该衍生物的方法。本发明进一步涉及包含本发明化合物的制药组合物，并用于治疗肿瘤和其他细胞增殖性疾病的方法。
• Immobilized N-substituted tricyclic 3-aminopyrazoles for the identification of biomolecular targets
  申请人：Ho Y. Chih

  公开号：US20050130910A1

  公开（公告）日：2005-06-16

  The present invention relates to immobilized N-substituted tricyclic 3-aminopyrazole compounds of Formula 1 as tools for the identification of bimolecular targets in cells of therapeutic significance, profiling the selectivity of compounds, prediction of possible related toxicities and exploration of mechanisms of action in biological systems for therapeutic indications related to compounds. These agents can be used to identify biomolecules with the potential to interact with the immobilized reagent. The identified biomolecule may be then be used as a therapeutic target, serve as a marker of drug action, or alternatively describe an untoward or toxic potential of the immobilized agent.

  本发明涉及式 1 的固定化 N-取代三环 3-氨基吡唑化合物，可用作鉴定细胞中具有治疗 意义的双分子靶标、分析化合物的选择性、预测可能的相关毒性以及探索生物系统中与复 合物相关的治疗适应症的作用机制的工具。这些制剂可用于识别可能与固定试剂发生相互作用的生物分子。识别出的生物分子可用作治疗靶标、药物作用标记，或描述固定化试剂的不良或毒性潜能。