1-(2-hydroxy-pyrrolidin-1-yl)-ethanone | 86968-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-hydroxy-pyrrolidin-1-yl)-ethanone
• 英文别名: 1-acetyl-pyrrolidin-2-ol；N-Acetyl-2-hydroxy-pyrrolidin；N-acetyl-2-hydroxypyrrolidine；1-(2-hydroxypyrrolidin-1-yl)ethanone
• CAS: 86968-39-0
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: PMUPYMPBTYMXDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-hydroxy-pyrrolidin-1-yl)-ethanone 、 乙酰乙酸乙酯 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 Ethyl 2-(N-acetylpyrrolidin-2-yl)-3-oxobutyrate
  参考文献：
  名称：

  Palladium-catalyzed carbonylation. A new synthesis of .alpha.-methylene .gamma.-, .delta.-, .epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine and indolizidine skeletons

  摘要：

  DOI：

  10.1021/jo00170a037
• 作为产物：
  描述：

  1-乙酰基吡咯烷 以 水 、 乙腈 为溶剂， 生成 1-(2-hydroxy-pyrrolidin-1-yl)-ethanone
  参考文献：
  名称：

  Palladium-catalyzed carbonylation. A new synthesis of .alpha.-methylene .gamma.-, .delta.-, .epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine and indolizidine skeletons

  摘要：

  DOI：

  10.1021/jo00170a037

文献信息

• Tandem hydroformylation–hydrazone formation–Fischer indole synthesis: a novel approach to tryptamides
  作者：Axel M. Schmidt、Peter Eilbracht

  DOI：10.1039/b503396a

  日期：——

  A novel one-pot synthesis of indole systems via tandem hydroformylation-hydrazone formation-Fischer indolization starting from allylic amides and aryl hydrazines is described. This tandem procedure directly leads to biologically interesting tryptamides and analogues.

  描述了通过烯丙基酰胺和芳基肼开始的通过串联加氢甲酰化-hydr形成-费歇尔吲哚化的新颖的一锅合成吲哚体系。该串联过程直接导致生物学上令人感兴趣的类胰酰胺和类似物。
• Polymers of self- and hydroxyl reactive formaldehyde-free cyclic
  申请人：Air Products and Chemicals, Inc.

  公开号：US04663410A1

  公开（公告）日：1987-05-05

  A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, or R and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, or R.sup.2 and R.sup.3 together are a C.sub.2 -C.sub.4 alkylene group, R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen. Under acidic conditions the above compounds in which R.sup.1 is hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula: ##STR2## The dialkyl acetal and ketal compounds and the cyclic hemiamidal and hemiamide ketal compounds can be homopolymerized or polymerized with other copolymerizable monomers.

  以下化合物的化学式：##STR1## 其中R是具有使氮原子电子不足的官能团的C.sub.3-C.sub.24烯烃不饱和有机基团，烯烃不饱和官能团是可聚合的，R.sup.1是氢或C.sub.1-C.sub.4烷基基团，或R和R.sup.1与氮原子一起可以形成具有使氮原子电子不足的烯烃不饱和5至7成员环，烯烃不饱和官能团是可聚合的，R.sup.2和R.sup.3是氢、C.sub.1-C.sub.4烷基或酰基基团，或R.sup.2和R.sup.3一起是C.sub.2-C.sub.4烷基撑链，R.sup.4是氢或C.sub.1-C.sub.4烷基、酰基、酯、酰胺或酸基团，n是1至10的整数，当R为(meth)acryloyl时，n不为1，R.sup.2和R.sup.3为甲基，R.sup.1和R.sup.4为氢。在酸性条件下，其中R.sup.1为氢的上述化合物会生成以下的环状半酰胺和半酰胺缩酮：##STR2## 双烷基缩醛和缩酮化合物以及环状半酰胺和半酰胺缩酮化合物可以与其他共聚单体进行均聚或共聚。
• Self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and
  申请人：Air Products and Chemicals, Inc.

  公开号：US04691026A1

  公开（公告）日：1987-09-01

  A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, or R and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, or R.sup.2 and R.sup.3 together are a C.sub.2 -C.sub.4 alkylene group, R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen. Under acidic conditions the above compounds having R.sup.1 =hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula ##STR2##

  以下是由以下公式表示的化合物：##STR1## 其中，R是具有使氮原子电子亏损的官能团的C.sub.3-C.sub.24烯烃不饱和有机基团，烯烃不饱和官能团具有可聚合性，R.sup.1是氢或C.sub.1-C.sub.4烷基基团，或者R和R.sup.1与氮原子一起可以形成具有使氮原子电子亏损的官能团的烯烃不饱和5到7元环，烯烃不饱和官能团具有可聚合性，R.sup.2和R.sup.3是氢、C.sub.1-C.sub.4烷基或酰基基团，或者R.sup.2和R.sup.3一起是C.sub.2-C.sub.4烷基基团，R.sup.4是氢或C.sub.1-C.sub.4烷基、酰基、酯、酰胺或酸基团，n是1到10的整数，当R为(meth)acryloyl，R.sup.2和R.sup.3为甲基，R.sup.1和R.sup.4为氢时，n不为1。在酸性条件下，具有R.sup.1=氢的上述化合物产生以下公式的环状半酰胺和半酰胺缩醛：##STR2##
• Polymers of self- and diol reactive formaldehyde-free crosslinking
  申请人：Air Products and Chemicals, Inc.

  公开号：US05463007A1

  公开（公告）日：1995-10-31

  A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, or R and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, or R.sup.2 and R.sup.3 together are a C.sub.2 -C.sub.4 alkylene group, R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen. Under acidic conditions the above compounds in which R.sup.1 is hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula: ##STR2## The dialkyl acetal and ketal compounds and the cyclic hemiamidal and hemiamide ketal compounds can be homopolymerized or polymerized with other copolymerizable monomers.

  以下化合物的化学式：##STR1## 其中，R是具有使氮原子电子不足的官能团的C.sub.3-C.sub.24烯丙基不饱和有机基，烯丙基不饱和官能团可聚合，R.sup.1是氢或C.sub.1-C.sub.4烷基基团，或R和R.sup.1与氮原子一起可以形成具有使氮原子电子不足的烯丙基不饱和5至7元环，烯丙基不饱和官能团可聚合，R.sup.2和R.sup.3是氢，C.sub.1-C.sub.4烷基或酰基基团，或R.sup.2和R.sup.3一起是C.sub.2-C.sub.4烷基基团，R.sup.4是氢或C.sub.1-C.sub.4烷基、酰基、酯基、酰胺基或酸基团，n是1至10的整数，当R为(meth)acryloyl，R.sup.2和R.sup.3为甲基，R.sup.1和R.sup.4为氢时，n不为1。在酸性条件下，其中R.sup.1为氢的上述化合物会生成以下的环状半酰胺和半酰胺醚：##STR2## 二烷基缩醛和缩酮化合物以及环状半酰胺和半酰胺醚化合物可以与其他共聚单体一起进行均聚或共聚。
• Self-and Hydroxyl reactive formaldehyde-free cyclic hemiamidal and
  申请人：Air Products and Chemicals, Inc.

  公开号：US04788288A1

  公开（公告）日：1988-11-29

  A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, or R and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, or R.sup.2 and R.sup.3 together are a C.sub.2 -C.sub.4 alkylene group, R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen. Under acidic conditions the above compounds having R.sup.1 =hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula ##STR2##

  以下化合物的化学式：##STR1## 其中R是具有使氮原子电子不足的官能团的C.sub.3-C.sub.24烯丙基不饱和有机基，烯丙基不饱和官能团可聚合，R.sup.1是氢或C.sub.1-C.sub.4烷基基团，或R和R.sup.1与氮原子一起可以形成具有使氮原子电子不足的烯丙基不饱和5至7环成员环，烯丙基不饱和官能团可聚合，R.sup.2和R.sup.3是氢，C.sub.1-C.sub.4烷基或酰基基团，或R.sup.2和R.sup.3一起是C.sub.2-C.sub.4烷基基团，R.sup.4是氢或C.sub.1-C.sub.4烷基，酰基，酯，酰胺或酸基团，n是1至10的整数，当R为（甲基）丙烯酰基，R.sup.2和R.sup.3为甲基，R.sup.1和R.sup.4为氢时，n不为1。在酸性条件下，具有R.sup.1 =氢的上述化合物会产生如下化合物的环状半胺和半胺酮：##STR2##