1-octadec-9'-enoyl-2-hydroxy-sn-glycero-3-phosphocholine | 4016-41-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1-octadec-9'-enoyl-2-hydroxy-sn-glycero-3-phosphocholine
• 英文别名: Lysolecithin；1-oleoyl-sn-glycero-3-phosphocholine；L-Alpha-Lysophosphatidylcholine,oleoyl；(2-hydroxy-3-octadec-9-enoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 4016-41-5
• 化学式: C₂₆H₅₂NO₇P
• 分子量: 521.675
• InChiKey: YAMUFBLWGFFICM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  35
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,3-二羟丙基(2-(三甲基铵)乙基)磷酸酯 、 1-Imidazol-1-yloctadec-9-en-1-one 在 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL 、 cadmium(II) chloride 作用下， 以 氯仿 、 二甲基亚砜 为溶剂， 反应 4.0h， 以4%的产率得到(2-heptadec-9-enoyloxy-3-octadec-9-enoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate
  参考文献：
  名称：

  Polymer-Supported Bases. XII. Regioselective Synthesis of Lysophospholipids Using Polymer-Supported Bicyclic Amidines or Guanidines

  摘要：

  1-Acylphosphatidylcholines were prepared in good yields by the regioselective monoacylation of L-alpha-glycerophosphorylcholine with acylimidazoles in the presence of polymer-supported bicyclic amidine of guanidine.

  DOI：

  10.1080/00397919408010612

文献信息

• Polymer-Supported Bases. XII. Regioselective Synthesis of Lysophospholipids Using Polymer-Supported Bicyclic Amidines or Guanidines
  作者：Y. Tamura、W. Fukuda、M. Tomoi、S. Tokuyama

  DOI：10.1080/00397919408010612

  日期：1994.11

  1-Acylphosphatidylcholines were prepared in good yields by the regioselective monoacylation of L-alpha-glycerophosphorylcholine with acylimidazoles in the presence of polymer-supported bicyclic amidine of guanidine.