1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8a-Hexadecafluoro-8,8-bis(trifluoromethyl)decahydronaphthalene

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8a-Hexadecafluoro-8,8-bis(trifluoromethyl)decahydronaphthalene
• 英文别名: 1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8a-hexadecafluoro-8,8-bis(trifluoromethyl)naphthalene
• 化学式: C₁₂F₂₂
• 分子量: 562.09
• InChiKey: PGVLJTPBGVZPPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  34
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  22

文献信息

• Perfusate for preserving organ to be transplanted and preserving method
  申请人：The Green Cross Corporation

  公开号：EP0033402A1

  公开（公告）日：1981-08-12

  An organ to be transplanted, such as a kidney, can effectively be preserved for an increased period of time by perfusion using a perfusate which is made of a Ringer's solution modified by increasing its potassium ion content to 8-20 meq/liter with a stably emulsified perfluorocarbon compound and dissolved albumin. A preferred concentration of the perfluorocarbon compound, for example perfluorodecalin, is 7.5 to 12.5%(W/V) and that of albumin is 1-8%(W/V) based on the perfusate.

  灌注液是由林格氏溶液改良而成，改良后的林格氏溶液将钾离子含量提高到 8-20 meq/升，并加入了稳定乳化的全氟碳化合物和溶解的白蛋白。全氟碳化合物（例如全氟萘烷）的优选浓度为 7.5-12.5%(W/V)，白蛋白的优选浓度为灌流液的 1-8%(W/V)。
• Artificial blood and other gas transport agents
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0091820A1

  公开（公告）日：1983-10-19

  Gas transport agents containing a perfluorocyclocarbon and an amine oxide are disclosed. These compositions provide emulsions or solutions for use in oxygen transport, particularly in animals. They are therefore useful as artificial blood compositions. Large concentrations of perfluorocarbons may be employed even up to 50% or more by volume in preparing emulsions, microemulsions or solutions. The emulsions or solutions are stable under room temperature storage conditions

  本发明公开了含有全氟环碳化物和氧化胺的气体运输剂。这些组合物提供的乳液或溶液可用于氧气输送，特别是动物体内的氧气输送。因此，它们可用作人造血液组合物。在制备乳剂、微乳剂或溶液时，可以使用高浓度的全氟碳化合物，按体积计算甚至可高达 50%或以上。这些乳剂或溶液在室温储存条件下非常稳定
• Extraocular device for treating the eye
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0112658A2

  公开（公告）日：1984-07-04

  Extraocular ophthalmic preparations or devices useful as therapeutic, diagnostic lubricating or protective agents are disclosed. Perfluorocarbon films or gels are employed extraocularly as contact lenses. Liquid perfluorocarbons and substituted derivatives are the active components of the ophthalmic preparations. The neat perfluorocarbon liquids are not aqueous, wherefore, isotonicity and pH need not be considered in their preparation. Liquid sterility may be maintained without the addition of preservatives. Cornea and conjunctiva surfaces are provided with greater amounts of oxygen when the perfluorcarbon liquids are employed as eye drops. Transparent contact lenses having oxygen permeable properties are provided by the extraocular perfluorocarbon films or discs. Emulsions of perfluorocarbons in water are also suitable for all of the above uses and as carriers for drugs, antibiotics, hormones and therapeutic agents.

  公开了可用作治疗、诊断润滑剂或保护剂的眼外眼科制剂或装置。全氟碳薄膜或凝胶可用作眼外隐形眼镜。液态全氟化碳和取代衍生物是眼科制剂的活性成分。纯净的全氟化碳液体不是水溶液，因此在制备过程中无需考虑等渗性和 pH 值。无需添加防腐剂即可保持液体无菌。当全氟碳化物液体用作滴眼液时，角膜和结膜表面可获得更多的氧气。眼外全氟碳化合物薄膜或圆片可提供具有透氧特性的透明隐形眼镜。全氟碳化合物在水中的乳化液也适用于上述所有用途，并可作为药物、抗生素、激素和治疗剂的载体。
• New polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants
  申请人：ATTA

  公开号：EP0255443A1

  公开（公告）日：1988-02-03

  Compounds having a polyhydroxylated hydrophilic moiety, a highly fluorinated moiety and a functional junction group linking said moieties together, wherein said hydrophilic moiety is derived from a polyol or an aminopolyol, and wherein said highly fluorinated moiety consists of a fluorocarbon group wherein at least 50 % of the atoms bonded to the carbon skeleton are fluorine atoms, the other atoms bonded to the carbon skeleton being hydrogen, chlorine or bromine atoms, said highly fluorinated moiety containing at least 4 fluorine atoms ; as well as the internal ethers and ketals thereof ; process for their preparation ; and compositions containing said compounds as surfactants together with non polar compounds, for use as gas carriers.

  具有一个多羟基亲水基团、一个高氟化基团和一个将上述基团连接在一起的功能连接基团的化合物，其中所述亲水基团来自多元醇或氨基多元醇，所述高氟化基团由碳氟化合物基团组成，其中与碳骨架结合的原子中至少有 50% 为氟原子，与碳骨架结合的其他原子为氢原子、氯原子或溴原子，所述高氟化基团至少含有 4 个氟原子；及其内醚和酮类；制备方法；以及含有上述化合物作为表面活性剂的组合物和用作气体载体的非极性化合物。
• Concentrated stable fluorchemical aqueous emulsions
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0282949A2

  公开（公告）日：1988-09-21

  A stable concentrated aqueous emulsion of perfluorochemical, a phos­pholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include addition emulsifiers of SURFYNOL®SE surfactant and PLURONIC® P-105 surfactant. The emulsion is produced using an improved emul­sification technique.

  一种由全氟化学品、磷脂和脂肪酸甘油三酯组成的稳定浓缩水乳液已经得到证实，它具有更高的稳定性、更小的粒径和更强的生物系统耐受性。这种乳液可用作氧气运输介质，如人造血液。乳液中还可添加 SURFYNOL®SE 表面活性剂和 PLURONIC® P-105 表面活性剂等乳化剂。该乳液采用改进的乳化技术制成。