S-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-hydroxythieno[3.2-b]pyridine-6-carboxamide | 153062-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: S-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-hydroxythieno[3.2-b]pyridine-6-carboxamide
• 英文别名: N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide
• CAS: 153062-96-5
• 化学式: C₁₅H₁₇N₃O₂S
• 分子量: 303.385
• InChiKey: AFUWQWYPPZFWCO-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Pyridoquinoxaline antivirals
  申请人：——

  公开号：US20030207877A1

  公开（公告）日：2003-11-06

  The present invention provides a compound of formula I 1 or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 and R 3 are as defined in the specification. The compounds are useful for the treatment of viral infections.

  本发明提供了一种具有以下结构的化合物I或其药学上可接受的盐，其中R1、R2和R3如规范中定义。这些化合物对于治疗病毒感染是有用的。
• ANTIVIRAL COMPOUNDS
  申请人：——

  公开号：US20040242884A1

  公开（公告）日：2004-12-02

  The invention provides a compound of formula I: 1 wherein G, R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpes virus infection using such compounds or salts.

  本发明提供了一种I式化合物：1，其中G，R2，R3和R4具有规范中定义的任何值，或其药学上可接受的盐，以及用于制备这种化合物或盐的有用中间体和过程，以及使用这种化合物或盐预防或治疗疱疹病毒感染的方法。
• Heteroaryl-ethanolamine derivatives as antiviral agents
  申请人：Schnute E. Mark

  公开号：US20050049245A1

  公开（公告）日：2005-03-03

  The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种如下所述的化合物，它们可用作抗病毒剂，特别是用作针对疱疹家族病毒的药物。
• PREVENTIVE OR THERAPEUTIC AGENTS FOR GASTRIC OR ESOPHAGEAL REGURGITATION
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1256581A1

  公开（公告）日：2002-11-13

  The compound of the following formula: wherein R1 and R2 independently represent a hydrogen atom or a lower alkyl group; A represents a group selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group, 1-azabicyclo[2.2.2]octyl group, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof or a hydrate thereof has both improving effect on enterokinetic functions and suppressing effect on acid secretion, and also is highly safe. Accordingly, the substance is useful as preventive or therapeutic medicament for a gastroesophageal reflux disease.

  下式的化合物： 其中 R1 和 R2 分别代表氢原子或低级烷基；A 代表选自 1-氮杂双环[3.2.2]壬基、1-氮杂双环[2.2.2]辛基或其 N-氧化物组成的组，或其药学上可接受的盐或其水合物，具有改善肠动力功能和抑制胃酸分泌的作用，而且安全性高。因此，该物质可用作胃食管反流病的预防或治疗药物。
• Preventive or therapeutic agents for gastric or esophageal regurgitation
  申请人：——

  公开号：US20030130304A1

  公开（公告）日：2003-07-10

  The compound of the following formula: 1 wherein R 1 and R 2 independently represent a hydrogen atom or a lower alkyl group; A represents a group selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group, 1-azabicyclo[2.2.2]octyl group, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof or a hydrate thereof has both improving effect on enterokinetic functions and suppressing effect on acid secretion, and also is highly safe. Accordingly, the substance is useful as preventive or therapeutic medicament for a gastroesophageal reflux disease.

  下式化合物 1 其中 R 1 和 R 2 A 代表选自 1-氮杂双环[3.2.2]壬基、1-氮杂双环[2.2.2]辛基、或其 N-氧化物、或其药学上可接受的盐或其水合物组成的组。因此，该物质可用作胃食管反流病的预防或治疗药物。