4-iodo-2-(trifluoromethoxy)thiophene | 1254174-58-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 4-iodo-2-(trifluoromethoxy)thiophene
• 英文别名: 4-Iodo-2-(trifluoromethoxy)thiophene
• CAS: 1254174-58-7
• 化学式: C₅H₂F₃IOS
• 分子量: 294.036
• InChiKey: QQDDCSOJEQMWJW-UHFFFAOYSA-N

物化性质

• 沸点：
  209.3±35.0 °C(Predicted)
• 密度：
  2.079±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  噻吩 、 双(三氟甲基)过氧化物 反应 0.25h， 以67.3%的产率得到2-iodo-5-(trifluoromethoxy)thiophene
  参考文献：
  名称：

  Co-thermolysis: a one-pot synthetic method for novel 2-substituted-5-(trifluoromethoxy)thiophenes

  摘要：

  A new 'green' process to obtain trifluoromethoxylated compounds by a gas-phase method has been accomplished. Through it, new 2-substituted-5-(trifluoromethoxy)thiophenes have been obtained in moderate to good yields. Though the reaction occurs in the gas-phase and radicals are involved, an electron transfer mechanism is also postulated to explain the appearance of all detected products. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.111

文献信息

• Co-thermolysis: a one-pot synthetic method for novel 2-substituted-5-(trifluoromethoxy)thiophenes
  作者：W.J. Peláez、G.A. Argüello

  DOI：10.1016/j.tetlet.2010.07.111

  日期：2010.10

  A new 'green' process to obtain trifluoromethoxylated compounds by a gas-phase method has been accomplished. Through it, new 2-substituted-5-(trifluoromethoxy)thiophenes have been obtained in moderate to good yields. Though the reaction occurs in the gas-phase and radicals are involved, an electron transfer mechanism is also postulated to explain the appearance of all detected products. (C) 2010 Elsevier Ltd. All rights reserved.